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CagriSema side effects

Also known as: Cagrilintide/semaglutide · Cagrilintide-semaglutide · Cagri-Sema · Cagri/Sema

Updated Oct 24, 202646 sources

10 side effects reported for CagriSema: 5 from studies and labels, 5 from users and guides. 4 come with the ways people manage them.

CagriSema overview

Side effects reported in studies and labels

Rates as each trial or label states them. A rate from one trial does not carry over to research-grade vials or other doses.

From trials and regulators5

Clinical studies and regulatory documents.

Gastrointestinal side effects (any)
79.6% vs 39.9% on placebo in REDEFINE 1; 72.5% vs 34.4% in REDEFINE 2. Mostly mild to moderate and short-lived.
How people manage it
- The trials stepped up the dose every 4 weeks and let investigators keep people on a lower dose.
Nausea
55% vs 12.6% on placebo in REDEFINE 1
Constipation
30.7% vs 11.6% on placebo in REDEFINE 1
Vomiting
26.1% vs 4.1% on placebo in REDEFINE 1
Stopping because of side effects
About 6% vs 3.5 to 3.7% on placebo in REDEFINE 1; 8.4% vs 3% in REDEFINE 2

Side effects users and guides report

What people post and what dosing guides list. These are reports, not measured rates.

From users and guides5

Community reports, competitor and vendor guides, media.

Tiredness and drowsiness
Commonly reported on r/CagriSema, often in the first weeks
How people manage it
- Some users say it tapers after a few weeks.
- One user said only lowering the dose to 0.25 mg helped with sleepiness after meals.
- Others went back to semaglutide alone.
Vomiting after starting too high
Reported on r/CagriSema by users who started at 1.25 to 1.5 mg, and after a first dose from a 10 + 10 mg vial
How people manage it
- Users and threads point to starting at 0.25 mg + 0.25 mg and stepping up every 4 weeks.
Constipation and day-after nausea
Reported on r/CagriSema, including by trial participants
How people manage it
- A former trial participant used bone broth and sparkling water on injection day and a stool softener after a day without a bowel movement.
Emotional flatness
Reported by a few trial participants on r/CagriSema
Reflux and sulfur burps
Reported on r/CagriSema in the first weeks of a trial

Who should avoid it, and what not to combine

Personal or family history of medullary thyroid cancer or MEN 2Condition
The semaglutide label contraindicates use in these people because of a boxed warning for thyroid C-cell tumors.
Pregnancy or planned pregnancyCondition
The semaglutide label says it may cause fetal harm and to stop at least 2 months before a planned pregnancy because of its long half-life.
Insulin or sulfonylureasSubstance
The semaglutide label warns that combining it with insulin or an insulin secretagogue raises the risk of low blood sugar; those doses may need to come down.

How much is known

Strong human trials

Several phase 3 trials of Novo's product: REDEFINE 1, 2, 4 and 9 and REIMAGINE 2 and 5, plus phase 1b and phase 2 work. No published data cover research premixed blends, whose identity and stability are unverified.