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Limited human dataFDA 503A Category 1

Glutathione dosage

Also known as: GSH · L-glutathione · Reduced glutathione · L-glutathione reduced · Gluta · Glutathione peptide · gamma-Glu-Cys-Gly

Updated 56 sources

Every Glutathione protocol on file, 19 in all, labelled by where each number came from. 1 have titration steps, each step is worked out in U-100 units for a 600 mg vial + 3 mL water.

Calculate with GlutathioneGlutathione overview

Glutathione dosage by goal

Grouped by goal. Each protocol shows the amount, how often, cycle and rest as the source states them, with every titration step.

Skin lightening2

Skin lightening (IV trial)

Amount
1,200 mg
How often
Twice a week
Route
Intravenous (IV)
Cycle
6 weeks

Who: 50 women in one placebo-controlled study (Zubair 2016)

Note: 37.5% lightened on glutathione vs 18.7% on placebo, and the effect faded over 6 months after stopping. The infusion also contained vitamin C.

Skin lightening (oral trial)

Amount
250 mg
How often
Twice daily (500 mg a day)
Route
Oral, capsule
Cycle
4 weeks

Who: 60 healthy medical students in Thailand

Note: Melanin index dropped at all six sites, beating placebo at two.

Other protocols: injected8

Starter (subQ or IM)

Amount
100 mg
How often
Twice a week, at least 48 hours apart
Route
SubQ, vial (powder)
Cycle
4 weeks, then reassess

Note: Guide convention for learning how the injection feels. At 200 mg/mL, 100 mg is 50 units. The same guide lists IM as an option and says it often stings less.

Standard (subQ or IM, the common home dose)

Amount
200 mg
How often
2 to 3 times a week
Route
SubQ, vial (powder)
Cycle
8 to 12 weeks
Rest
4 weeks off

Note: No controlled trial has tested injected glutathione below 600 mg, so this dose is convention. At 200 mg/mL a 200 mg dose fills a whole 1 mL syringe.

Daily titration (subQ)

Amount
100 to 200 mg
How often
Once daily, stepping 100 then 150 then 200 mg
Route
SubQ, vial (powder)
Cycle
4 to 8 weeks
Rest
Optional 2 to 4 weeks off

Timing: Any consistent time of day.

Titration steps for Daily titration (subQ)
WhenDoseU-100 units (600 mg vial + 3 mL water)
Weeks 1 to 2100 mg50 units · 0.5 mL
Weeks 3 to 4150 mg75 units · 0.75 mL
Weeks 5 to 8200 mg100 units · 1 mL

Note: Built for a 600 mg vial mixed with 2 mL (300 mg/mL). The same guide allows every-other-day dosing instead of daily.

Maintenance (subQ)

Amount
200 mg
How often
Once or twice a week
Route
SubQ, vial (powder)

Injection range (IM or subQ)

Amount
200 to 600 mg
How often
1 to 3 times a week
Route
IM, vial (powder)
Cycle
4 to 12 weeks

IM as reported on r/Peptides

Amount
200 to 600 mg
How often
Once a week to every other day
Route
IM, vial (powder)

Note: Posters pick delts or glutes over the thigh, which several say hurts most. One poster ran 1.5 g a week into the glutes and noticed little change.

SubQ as reported on r/Peptides

Amount
100 to 250 mg
How often
3 to 5 times a week
Route
SubQ, vial (powder)

Note: SubQ users report more sting and lumps than IM users. Posters warn that big volumes under the skin clear slowly.

Chemotherapy nerve protection (IM, trial)

Amount
600 mg
How often
On days 2 to 5 of each weekly chemo cycle
Route
Intramuscular injection

Who: 50 people with advanced gastric cancer on weekly cisplatin

Note: Each week also started with 1.5 g/m2 IV just before cisplatin. Neuropathy was much rarer than on placebo. A medical protocol, not a home plan.

Other protocols: intravenous (iv)2

Clinic IV sessions

Amount
600 to 1,200 mg
How often
Once or twice a week
Route
Intravenous (IV)

Note: Clinic practice, mostly for skin lightening. IV is the route behind most of the serious adverse event reports. For tested athletes, a drip over 100 mL in 12 hours outside hospital care is a WADA-prohibited method.

Parkinson's disease (IV trial)

Amount
1,400 mg
How often
3 times a week
Route
Intravenous (IV)
Cycle
4 weeks

Who: 21 people with Parkinson's disease not well controlled on their medicines

Note: Well tolerated, but no significant difference from placebo on the UPDRS.

Other protocols: iv, ready-to-use vial1

Compounded injection (pharmacy page)

Amount
600 to 1,400 mg
How often
2 to 3 times a week
Route
IV, ready-to-use vial

Note: The pharmacy says its 200 mg/mL injection is given IV or IM by a healthcare professional and that the prescriber sets dose and frequency.

Other protocols: oral, capsule4

Body stores (oral trial)

Amount
250 to 1,000 mg
How often
Daily
Route
Oral, capsule
Cycle
6 months

Who: 54 healthy non-smoking adults

Note: Both doses raised blood glutathione, and levels fell back to baseline a month after stopping.

Skin (lower oral dose, trial)

Amount
250 mg
How often
Once daily
Route
Oral, capsule
Cycle
12 weeks

Who: Healthy women

Fatty liver (oral pilot)

Amount
300 mg
How often
Daily
Route
Oral, capsule
Cycle
4 months

Who: 34 people with NAFLD, open-label, no placebo arm

Note: ALT fell after 4 months. No control group, so the effect size is uncertain.

Oral twice daily (trial, no effect)

Amount
500 mg
How often
Twice daily
Route
Oral, capsule
Cycle
4 weeks

Who: 40 healthy adults

Note: No change in oxidative stress markers or glutathione status. This is the main trial behind the claim that plain oral glutathione does not absorb.

Other protocols: oral1

Liposomal (oral pilot)

Amount
500 to 1,000 mg
How often
Daily
Route
Oral
Cycle
1 month

Who: 12 healthy adults

Note: Blood glutathione rose within 1 to 2 weeks. Tiny study; no difference between the two doses.

Other protocols: nasal, nasal spray1

Intranasal (Parkinson's trial)

Amount
100 to 200 mg
How often
3 times a day
Route
Nasal, nasal spray
Cycle
3 months

Who: 45 people with early to mid-stage Parkinson's disease

Note: All groups improved, placebo included; neither dose beat placebo. One person on the high dose developed cardiomyopathy.

Doses shown are what sources report, labelled by origin. Not medical advice.

Glutathione dosage chart by vial size

Units to draw for the doses sources cite most, at every vial size and water volume.
Glutathione: concentration and U-100 syringe units for each vial size and water volume
WaterStrength100 mgdose, units200 mgdose, units600 mgdose, units
200 mg vial
2 mLCompetitor guide100 mg/mL1001 mL2002 mL2 draws6006 mL6 draws
600 mg vial
2 mLCompetitor guide300 mg/mL33.30.333 mL66.70.667 mL2002 mL2 draws
3 mLCompetitor guide200 mg/mL500.5 mL1001 mL3003 mL3 draws
750 mg vial
2 mLCompetitor guide†375 mg/mL26.70.267 mL53.30.533 mL1601.6 mL2 draws
3 mLCompetitor guide†250 mg/mL400.4 mL800.8 mL2402.4 mL3 draws
5 mLCommunity-reported†150 mg/mL66.70.667 mL133.31.333 mL2 draws4004 mL4 draws
6 mLCommunity-reported†125 mg/mL800.8 mL1601.6 mL2 draws4804.8 mL5 draws
1,000 mg vial
2 mLCompetitor guide†500 mg/mL200.2 mL400.4 mL1201.2 mL2 draws
3 mLCompetitor guide†333.333 mg/mL300.3 mL600.6 mL1801.8 mL2 draws
5 mLCommunity-reported†200 mg/mL500.5 mL1001 mL3003 mL3 draws
6 mLCommunity-reported†166.667 mg/mL600.6 mL1201.2 mL2 draws3603.6 mL4 draws
1,200 mg vial
3 mLCompetitor guide400 mg/mL250.25 mL500.5 mL1501.5 mL2 draws
5 mLCommunity-reported240 mg/mL41.70.417 mL83.30.833 mL2502.5 mL3 draws
1,500 mg vial
3 mLCommunity-reported500 mg/mL200.2 mL400.4 mL1201.2 mL2 draws
5 mLCommunity-reported300 mg/mL33.30.333 mL66.70.667 mL2002 mL2 draws
6 mLCommunity-reported250 mg/mL400.4 mL800.8 mL2402.4 mL3 draws
Units are on a U-100 insulin syringe (100 units = 1 mL). U-50 and U-30 barrels read the same units.† Water volume sourced for a different vial size. The math is exact either way.Water volumes from

Doses shown are what sources report, labelled by origin. Not medical advice.

Calculate with this peptideYour vial, your water, your dose: Glutathione in syringe units, with the math shown.

Mixing Glutathione

Diluent: Bacteriostatic water (some users prefer bacteriostatic saline)

Water volumes sources use: 2 mL, 3 mL, 5 mL, 6 mL

Plan around volume: at 200 mg/mL a 200 mg dose fills a whole 1 mL syringe, and larger doses will not fit. Strong mixes near 300 mg/mL turn thick and sting more, so posters dilute back to 200 mg/mL. Good reduced glutathione dissolves clear, sometimes after sitting a while; powder that turns milky and settles is a red flag.

If you miss a dose

Take the next scheduled dose and carry on. With a plasma half-life of about 14 minutes there is no level to catch up on. After a gap of more than two weeks, one guide restarts at the starter dose.

Glutathione dosage questions

What is the usual glutathione injection dose per week?

Guides put the home dose at 200 mg two to three times a week (400 to 600 mg a week), starting at 100 mg twice a week. On r/Peptides people run 200 to 600 mg IM anywhere from once a week to every other day. Clinics give 600 to 1,200 mg IV once or twice a week. No trial has tested the 100 to 200 mg home doses.

How much glutathione should you take a day by mouth?

Oral trials used 250 to 1,000 mg a day. 250 mg a day lightened skin a little over 12 weeks, 500 mg a day over 4 weeks, and 250 or 1,000 mg a day raised blood levels over 6 months. Supplement labels commonly suggest one to three capsules a day.

What is the maximum glutathione dose per day?

No maximum has been set. The highest repeated oral dose in a long trial was 1,000 mg a day for 6 months, and a single 3 g oral dose was tested for absorption. IV trials used 1,400 mg three times a week. One compounding pharmacy says risks rise above 5 grams.

How do you reconstitute a 600 mg or 1,500 mg glutathione vial?

For 600 mg, guides use 3 mL (200 mg/mL, so 100 mg is 50 units) or 2 mL (300 mg/mL). For 1,500 mg, r/Peptides users report 3 to 6 mL. Run the water down the vial wall, swirl, and let it sit until clear. Stronger mixes get thick and sting more.

How long does mixed glutathione last in the fridge?

Guides say 28 days at 2 to 8 C, out of light. That figure comes from a pharmacy's preserved vial, and a self-mixed vial has no stability data, so some users finish a vial within a week or two. Discard it if it turns cloudy or dark.

What is the liposomal glutathione dosage?

The liposomal pilot used 500 or 1,000 mg a day for a month and saw no difference between doses. Consumer labels are lower: one lists 100 mg per 1 mL serving, held under the tongue.

Can I mix glutathione with NAD+ or GHK-Cu in one syringe?

Users who run these together on r/Peptides mostly keep them in separate syringes. Posters warn against combining glutathione and GHK-Cu, and NAD+ users dose it apart. No stability data exists for any mix.

Sources for these doses

28 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory1

  1. WADA 2026 Prohibited ListWADA · checked Oct 24, 2026

Vendor guide1

  1. Glutathione InjectionEmpower Pharmacy · checked Oct 24, 2026

Competitor guide6

  1. Glutathione dosage chartpeptidedeck.com · checked Oct 24, 2026
  2. Glutathione (600 mg vial) dosage protocolpeptidedosages.com · checked Oct 24, 2026
  3. Glutathione dosingpeptideprotocolwiki.com · checked Oct 24, 2026
  4. Glutathione protocol guidepeptidedosingprotocols.com · checked Oct 24, 2026

Community-reported10

  1. Anyone here doing Glutathione injection (comment: 200 mg every other day)r/Peptides · checked Oct 24, 2026
  2. Anyone here doing Glutathione injection (comment: 600 mg IM weekly)r/Peptides · checked Oct 24, 2026
  3. Anyone here doing Glutathione injection (comment: 300 mg IM every other day)r/Peptides · checked Oct 24, 2026
  4. Glutathione Sub Q (comment: 1 mL twice a week)r/Peptides · checked Oct 24, 2026

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