Glutathione news and clinical trials

New randomized trial in Medicine: Hyaluronic acid-based skin booster with glutathione combined with 1064-nm Nd:YAG laser and oral tranexamic acid for melasma: A prospective comparative study.

New systematic review in Basic & clinical pharmacology & toxicology: Evidence on Glutathione and Boosters for Prevention of Chemotherapy-Induced Neuropathy: A Systematic Review and Network Meta-Analysis.

Centric Compounding LLC initiated a voluntary recall of Tri-Immune Boost, containing glutathione, ascorbic acid, and zinc, due to microbial contamination. Out of specifications results for bacterial endotoxin were obtained during testing.

Optimal Balance Pharmacy initiated a Class I recall of 53 vials of glutathione 200 mg/mL injection due to microbial contamination. The pharmacy found out of specifications results for bacterial endotoxin.

Victory Medical Center Pharmacy initiated a Class I recall of 91 vials of glutathione 200 mg/mL solution because of microbial contamination. The firm identified the issue after obtaining out of specifications results for bacterial endotoxin.

A systematic review of glutathione research from 2004 to 2025 highlights a gap between fundamental biochemical findings and proven clinical therapeutic efficacy. Analysts noted that clinical studies often struggle with low oral bioavailability and rapid enzymatic degradation.

Krishnadevaraya College of Dental Sciences & Hospital registered a split-mouth clinical trial with 15 participants to compare the effectiveness of microneedling alone versus microneedling combined with 0.5 % glutathione gel for gingival depigmentation.

Krishnadevaraya College of Dental Sciences & Hospital completed a split-mouth trial with 15 participants evaluating the use of microneedling with 0.5 % glutathione gel versus microneedling alone for treating gingival hyperpigmentation.

The University of Bari registered a crossover study with 42 participants to evaluate the effects of a nutraceutical formulation called GLUT-F, containing silibin, glutathione, and vitamin E, on liver function in patients with metabolic dysfunction-associated steatotic liver disease.

The University of Thessaly registered a study with 20 soccer players to examine the pharmacodynamics and pharmacokinetics of 200 mg and 500 mg S-Acetyl Glutathione doses versus placebo to determine their impact on performance recovery.

A meta-analysis of 15 in vitro studies evaluated the impact of reduced glutathione supplementation on post-thaw boar sperm quality. Results showed a positive association between glutathione use and improved total motility, progressive motility, viability, and acrosome integrity.

Investigators compared the pharmacokinetics of an orally dissolving film and a conventional tablet formulation of glutathione in a randomized controlled trial with healthy adults. The film formulation showed higher plasma concentrations and a trend toward greater systemic exposure.

A systematic review and meta-analysis published in Cellular and Molecular Biology found that carriers of the GSTM1-null polymorphism have an increased risk of cervical cancer, particularly among HPV+ women and those exposed to tobacco smoke.

Children's Hospital of Philadelphia registered an observational study to measure glutathione and GABA levels using magnetic resonance spectroscopy in 60 patients with Friedreich's ataxia before and after treatment with Omaveloxolone.

Greater Atlanta Integrative Pediatrics registered a phase 1 study of 100 participants to evaluate the safety and effects of AdiaVita and glutathione versus glutathione alone for autism spectrum disorder.

Cairo University registered a phase 2 trial to compare the effectiveness of injecting vitamin C and glutathione versus surgical scalpel removal for treating gingival hyperpigmentation in 30 participants.

The University of Bari completed a crossover trial with 42 participants evaluating the effects of the nutraceutical GLUT-F, which includes glutathione and silibin, on hepatic steatosis and liver function in adults with metabolic dysfunction-associated steatotic liver disease.

Adia Med of Winter Park LLC registered a phase 1 trial to evaluate if AdiaVita, a combination of umbilical cord blood-derived stem cells, exosomes, and glutathione, improves kidney function in 100 adults with chronic kidney disease.

A systematic review and meta-analysis of 30 studies involving 1019 patients found significantly decreased glutathione peroxidase activity in individuals with depression. Other markers like glutathione and glutathione reductase showed no significant differences between groups.

NovoBliss Research Pvt Ltd completed a trial with 62 participants to assess the safety and efficacy of Oziva Bioactive Gluta Fizzy effervescent tablets containing glutathione for treating facial hyperpigmentation and dark spots.

A systematic review of 194 studies regarding glutathione in dermatology found that topical and oral applications improve skin pigmentation, brightness, and hydration. Analysts noted that injectable glutathione increases systemic levels rapidly but faces safety concerns.

New systematic review in Amino acids: The role of N-acetylcysteine and glutathione in the management of Parkinson's disease: a systematic review of oxidative biomarkers and clinical outcomes.

Assiut University registered a phase 2/3 study comparing the efficacy of oral tranexamic acid and glutathione-assisted microneedling, alone or in combination, for treating melasma in 42 participants.

Researchers conducted a randomized crossover trial with 30 physically active older adults to examine the effects of creatine and β-hydroxy-β-methylbutyrate (HMB) supplementation. The study found the combination was associated with nominal modulation of glutathione-centered redox balance.

A phase II study of 42 breast cancer survivors found that a 5-week acupuncture intervention significantly improved the glutathione redox balance by reducing oxidized glutathione and increasing the GSH/GSSG ratio, though these changes did not correlate with symptom improvements.

TCI Co., Ltd. completed a clinical trial evaluating whether Double Nutri liposomal encapsulation technology enhances the oral absorption of liquid vitamin C and glutathione. The study enrolled 20 participants.

TCI Co., Ltd. registered a clinical trial to evaluate the effects of a liquid vitamin C and glutathione sachet on skin condition and anti-oxidation. The study aims to enroll 30 participants and is estimated to be completed by June 1, 2026.

Universitas Padjadjaran registered a study investigating the effects of daily white tea consumption on antioxidant enzymes, including glutathione peroxidase, in 19 healthy participants.

Qualia Life Sciences completed a trial with 56 participants evaluating the impact of two Qualia Glutathione+ formulations on blood glutathione levels in healthy adults aged 45-75 years. The study compared these formulations against a placebo over a 20-day period.

Factors Group of Nutritional Companies Inc. completed a study evaluating the safety and pharmacokinetics of a new micellar glutathione formulation, LipoMicel, compared to standard and liposomal glutathione in 16 healthy participants.

Universitas Padjadjaran completed a study assessing the impact of a 14-day white tea intervention on antioxidant enzyme activity, specifically superoxide dismutase and glutathione peroxidase, in 19 healthy subjects.

Adia Med of Winter Park LLC registered a study with 100 participants to test if AdiaVita umbilical cord blood-derived stem cells and exosomes plus glutathione improve autism symptoms in children aged 3-12 compared to glutathione alone.

TCI Co., Ltd. registered a trial to test if Double Nutri liposomal encapsulation technology improves the absorption of liquid vitamin C and glutathione. The study enrolled 20 participants and completed data collection on February 2, 2026.

A secondary analysis of a randomized clinical trial involving 60 patients with clozapine-resistant schizophrenia found that 6 weeks of adjunctive sodium benzoate treatment increased plasma glutathione levels and correlated with improvements in functional outcomes and symptoms.

New meta-analysis in Pharmacogenetics and genomics: Effects of glutathione- S -transferase polymorphisms on intravenous busulfan in hematopoietic stem cell transplant patients: a meta-analysis.

King Edward Medical University registered a phase 2 trial comparing the effectiveness of tranexamic acid mesotherapy versus glutathione mesotherapy for post-burn facial hyperpigmentation. The study will enroll 60 participants to evaluate treatment outcomes on the cheek or forehead.

A post hoc analysis of the phase 3 ReCePI trial found that patients receiving amustaline/glutathione pathogen-reduced red blood cell transfusions required 17.6% less total hemoglobin than the control group to maintain equivalent daily hemoglobin levels.

Qualia Life Sciences completed a double-blind, placebo-controlled study with 56 participants to evaluate the impact of two Qualia Glutathione+ formulations on blood glutathione levels. The study assessed changes in glutathione after a 20-day daily regimen in healthy adults aged 45-75.