Humanin news and clinical trials

A study in The Journal of biological chemistry explored how humanin variants regulate BID fibrilization and membrane permeability. Findings showed that humanin reduces BAX- and tBID-mediated membrane permeabilization, integrating residue-level determinants into a framework for apoptosis regulation.

Researchers published a study in Neuroscience showing that humanin mitigates cellular senescence in neuronal cells. Chronic treatment with the humanin derivative HNG sustained neurotransmitter release and synapsin expression in differentiated PC12 cells exposed to glutamate.

Researchers studied the effects of Humanin in mice with Klebsiella pneumoniae infection and in 20 human patients. They found that Humanin pretreatment reduced liver injury, decreased NF-κB inflammatory signaling, and prolonged survival in the mice.

A study of 154 patients hospitalized for chronic heart failure found that a standardized rehabilitation protocol involving exercise and nutritional support improved physical performance compared to a control group and helped evaluate the prognostic value of the Humanin/CRP ratio.

A review article published in Alpha psychiatry discusses the antidepressant mechanism of low-dose ketamine. The authors hypothesize that ketamine acts on astrocyte mitochondria to upregulate humanin, adenosine, and melatonin, which restores cellular function and reduces inflammation.

A study in Experimental physiology investigated S14G-humanin (HNG) in rats with renal ischemia-reperfusion injury. HNG mitigated injury by reducing oxidative stress and inflammation, while also enhancing mitochondrial function through STAT3 and ERK1/2 activation.

Researchers published an analysis of the Humanin protein family interactome, identifying it as a regulatory network for stress responses rather than an isolated mitochondrial effector. The study revealed that Humanin-related proteins function as modulatory nodes linking signaling to larger modules.

Researchers found that S14G-humanin (HNG) treatment in diabetic mice alleviated renal injury. The peptide inhibited tubular necroptosis by blocking mitochondrial Z-DNA leakage and suppressing ZBP1-mediated cell death.

Researchers found that Humanin administration in male rats reversed paroxetine-induced reproductive and behavioral impairments. The peptide restored sperm quality, hormone levels, and dopaminergic activity in the nucleus accumbens and medial preoptic area.

Researchers tested Humanin-G in Royal College of Surgeons rats to treat retinal degeneration. They found that high-dose treatment altered gene expression in the retina and resulted in significant improvement in visual acuity measured by optokinetic testing.

A study in diabetic mice found that daily administration of 4 mg/kg of Humanin for 15 days reduced oxidative stress, inflammation, and apoptosis in cardiac tissue. The results suggest Humanin helps restore redox and inflammatory balance in the diabetic heart.

Researchers found that placental mRNA expression levels of six small humanin-like peptides were significantly reduced in women with gestational diabetes mellitus compared to controls. This decrease correlated with higher insulin resistance and glycated hemoglobin values.

A study in Experimental physiology found that humanin ameliorates diabetes-induced testicular damage in mice. Humanin treatment significantly improved antioxidant levels and reduced histopathological damage such as seminiferous tubule degeneration.

Researchers demonstrated that Humanin exerts a cytoprotective effect on granulosa cells in human cell lines and rat ovary cultures. The peptide reduced oxidative-stress-induced apoptosis by modulating apoptosis-related genes and enhancing antioxidant capacity.

The University of Gaziantep registered a prospective controlled study comparing the effects of general anesthesia and combined spinal-epidural anesthesia on ferroptosis, humanin, and MOTS-c levels in 68 renal transplant recipients.

Researchers administered 4 mg/kg of Humanin daily for 15 days to diabetic mice and found it restored homeostasis of key metabolic hormones including leptin, ghrelin, irisin, and asprosin. The treatment effectively countered the hormonal disruptions caused by streptozotocin-induced diabetes.

Researchers demonstrated that Humanin protects retinal pigment epithelium cells from amyloid beta-induced injury by activating AMPK to promote mitophagy. This pathway clears accumulated mitochondria and helps preserve barrier integrity.

Researchers published an article discussing the potential therapeutic role of Humanin in treating acute respiratory distress syndrome. The study highlights the emerging evidence for mitochondrial-derived peptides as cytoprotective agents in this condition.

Researchers treated Royal College of Surgeons rats with intraperitoneal Humanin-G injections to address retinal degeneration. A high dose of 4 mg/kg administered for 4 weeks improved visual acuity and altered gene expression in the retina and RPE.

A study of 49 ejaculates from crossbred cattle found that Humanin levels in seminal plasma were positively correlated with sperm concentration and motility. The peptide was identified as a potential marker for selecting high-quality, freezable bull semen.

Researchers observed that Humanin and MOTS-c levels are downregulated in human atrial fibrillation tissue. Administering these peptides to mice reduced atrial fibrosis and mitochondrial dysfunction while lowering atrial fibrillation inducibility.

Researchers identified that the mitochondrial peptide HNG protects lung vascular endothelial cells in a murine model of septic ARDS. Pretreatment with HNG reduced inflammatory markers and restored mitochondrial function by suppressing STAT3 expression.

Researchers found that Humanin pretreatment protects PC12 cells from rotenone-induced neurotoxicity. The peptide increased cell survival and reduced oxidative stress by activating the SIRT3/Nrf2/HO-1 signaling pathway.

A review article in Medecine Sciences discusses the potential function of the mitochondrial peptide Humanin in the resolution of inflammation.

Researchers injected RCS rats with Humanin-G to assess its effect on retinal degeneration. High dose HNG at 4 mg/kg significantly improved visual acuity at 4 weeks compared to low dose HNG or saline controls.

Researchers analyzed 49 patients and found that high adherence to the Mediterranean diet correlates with increased levels of the mitochondrial microproteins SHMOOSE and Humanin. Humanin levels showed an inverse association with markers of oxidative stress.

A study comparing Humanin sequences across various mammalian species concluded that evolution has tuned the peptide to optimize mitochondrial protection based on specific metabolic and environmental stressors. The findings provide a structural basis for developing new therapeutic Humanin analogs.

New paper in Cardiorenal medicine: Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.

Researchers evaluated the effects of the Humanin fragment peptide HNF 14 in transmitochondrial retinal pigment epithelial cell lines derived from AMD patients. Treatment with HNF 14 reduced intracellular oxidative stress, suppressed inflammatory markers, and improved metabolic activity.

Researchers measured serum humanin-like 3 levels in patients with multiple sclerosis and healthy controls to test its potential as a diagnostic biomarker. MS patients with spinal cord and optic nerve involvement showed a 5.26 ng/ml cutoff level that discriminated them from NMOSD patients.

Researchers tested whether the mitochondrial-derived peptides MOTS-c and S14G-humanin could mitigate muscle atrophy in human myotubes induced by 10 µM dexamethasone. Co-treatment with MOTS-c preserved myotube area and fusion index, while HNG co-treatment also preserved myotube area.