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Some human trialsFDA 503A Category 2

MK-677 (Ibutamoren) dosage

Also known as: MK-677 · Ibutamoren · Ibutamoren mesylate · MK-0677 · MK677 · LUM-201 · L-163,191

Updated 26 sources

Every MK-677 (Ibutamoren) protocol on file, 16 in all, labelled by where each number came from.

Calculate with MK-677 (Ibutamoren)MK-677 (Ibutamoren) overview

MK-677 (Ibutamoren) dosage by goal

Grouped by goal. Each protocol shows the amount, how often, cycle and rest as the source states them, with every titration step.

Trial7

Trial: 2-year study in older adults

Amount
25 mg
How often
Once daily
Route
Oral
Cycle
2 years

Who: 65 healthy adults aged 60 to 81

Note: Fat-free mass rose 1.1 kg vs a 0.5 kg loss on placebo, with no gain in strength or function. Fasting glucose rose about 5 mg/dL.

Trial: dose comparison in older adults

Amount
2 to 25 mg
How often
Once daily
Route
Oral
Cycle
14 and 28 day periods

Who: 32 healthy adults aged 64 to 81

Note: GH rose with dose. At 25 mg, 24-hour GH rose 97% and IGF-1 reached young-adult levels by 4 weeks.

Trial: bedtime dosing and sleep

Amount
5 to 25 mg
How often
Once daily at bedtime
Route
Oral
Cycle
7 to 14 day periods

Who: 8 young adults (older adults took 2 and 25 mg for 14 days)

Timing: At bedtime.

Note: 25 mg raised deep (stage IV) sleep about 50% and REM sleep more than 20% in young adults.

Trial: obese men

Amount
25 mg
How often
Once daily
Route
Oral
Cycle
8 weeks

Who: 24 obese men aged 18 to 50

Note: IGF-1 rose about 40% and fat-free mass rose; body fat did not change, and glucose tolerance worsened.

Trial: calorie deficit

Amount
25 mg
How often
Once daily
Route
Oral
Cycle
7 days

Who: 8 healthy adults aged 24 to 39 on a restricted diet

Note: Reversed the protein (nitrogen) loss from dieting.

Trial: hip-fracture recovery (stopped early)

Amount
25 mg
How often
Once daily
Route
Oral
Cycle
24 weeks planned

Who: 123 elderly hip-fracture patients

Note: Stopped early over a congestive heart failure signal in a limited number of patients.

Trial: children with GH deficiency (LUM-201)

Amount
0.8 to 3.2 mg/kg
How often
Once daily
Route
Oral

Who: Prepubertal children with GH deficiency in Lumos Pharma trials

Note: Pediatric trials only: these are per-kg doses for prepubertal children with growth hormone deficiency, not an adult protocol. Phase 2 compared 0.8, 1.6 and 3.2 mg/kg a day with daily GH injections. The Phase 3 trial (recruiting) uses 1.6 mg/kg a day.

Other protocols: oral9

Standard

Amount
10 to 25 mg
How often
Once daily, every evening before bed
Route
Oral
Cycle
8 to 16 week cycles, or continuous with glucose checks

Timing: Before bed, to sleep through the hunger and line up with the night GH pulse.

Note: The guide starts at 10 mg for 2 weeks; most users settle at 15 to 25 mg.

Conservative / anti-aging

Amount
10 mg
How often
Once daily at bedtime, or 5 days on and 2 off
Route
Oral

Note: Ongoing use with blood work every 3 months (glucose, IGF-1, HbA1c).

Performance / muscle building

Amount
25 mg
How often
Once daily at bedtime
Route
Oral
Cycle
12 to 16 weeks
Rest
4 to 8 weeks off

Start low, then the trial dose

Amount
10 to 25 mg
How often
Once daily before bed
Route
Oral
Cycle
12 weeks; 12 on and 4 to 6 off is the guide's standard cycle

Timing: Before bed, 2 or more hours after the last meal.

Titration steps for Start low, then the trial dose
WhenDose
Weeks 1 to 410 mg
Weeks 5 to 1225 mg

Note: The guide reassesses at week 4 and moves up to 20 to 25 mg only if 10 mg is tolerated; it says many people stay at 10 mg and tells readers not to exceed 25 mg a day.

Split dose for evening hunger

Amount
12.5 mg
How often
Twice daily: morning fasted and before bed
Route
Oral

Note: Spreads the appetite effect across the day; the daily total stays at 25 mg.

Low dose, long term

Amount
10 mg
How often
Once daily before bed
Route
Oral
Cycle
Weeks 1 to 24

Community standard

Amount
25 mg
How often
Once daily, morning or before bed
Route
Oral
Cycle
8 to 16 weeks

Community beginner

Amount
10 to 15 mg
How often
Once daily
Route
Oral
Cycle
8 to 12 weeks

Note: Used to judge hunger and water retention before going higher.

Community extended low dose

Amount
10 to 12.5 mg
How often
Once daily
Route
Oral
Cycle
3 to 6 months; some run 6+ months

Doses shown are what sources report, labelled by origin. Not medical advice.

Mixing MK-677 (Ibutamoren)

Sources give no mixing notes for this product.

MK-677 (Ibutamoren) dosage questions

How much MK-677 per day?

10 to 25 mg once a day is the usual range. Almost every adult trial used 25 mg. Many people start at 10 mg to see how the hunger and water retention go, and some stay there. Guides say going above 25 mg adds side effects without much more IGF-1.

How bad is the hunger and water retention?

Real but usually temporary. In the 2-year trial, more appetite was the top side effect and faded within a few months; leg swelling was mild and transient. Guides say the hunger peaks in the first 2 to 4 weeks and is gentler at 10 mg.

Do I need to cycle MK-677?

Nobody has proven it. Common cycles are 8 to 16 weeks on, or 12 to 16 on with 4 to 8 off. The longest trial ran 2 years straight at 25 mg and IGF-1 stayed up. Glucose is the usual reason people take breaks.

Sources for these doses

12 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide3

  1. MK-677PeptidesExplorer · checked Oct 24, 2026
  2. MK-677 (Ibutamoren) dosage guideBodyHackGuide · checked Oct 24, 2026
  3. MK-677 (Ibutamoren) protocol guidePathToPeptides · checked Oct 24, 2026

Community-reported1

  1. Ibutamoren (MK-677): community protocols and reportsPeptide Protocol Wiki, via a competitor guide · checked Oct 24, 2026

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