Limited human dataNot FDA approved

Pinealon side effects

Also known as: EDR peptide · Glu-Asp-Arg · H-Glu-Asp-Arg-OH · L-Glutamyl-L-aspartyl-L-arginine · Пинеалон · Peptide complex AC-5

Updated Oct 24, 202635 sources

6 side effects reported for Pinealon: 1 from studies and labels, 5 from users and guides. 3 come with the ways people manage them.

Pinealon overview

Side effects reported in studies and labels

Rates as each trial or label states them. A rate from one trial does not carry over to research-grade vials or other doses.

From trials and regulators1

Clinical studies and regulatory documents.

Lab changes in a small study
One Russian study of pinealon and vesugen in 32 adults aged 41 to 83 saw a pro-oxidant effect and lower CD34+ blood stem cell markers

Side effects users and guides report

What people post and what dosing guides list. These are reports, not measured rates.

From users and guides5

Community reports, competitor and vendor guides, media.

Injection-site redness, itch or irritation
The most commonly reported issue across guides and app logs
How people manage it
- Rotate sites
Mild headache
Early in a cycle, usually the first few days
Vivid dreams or changed sleep
During the first week
How people manage it
- Dose earlier in the day
Insomnia
A single Reddit report of lasting insomnia after pinealon with N-acetyl epitalon
Stomach upset
Mild, with oral capsules; called rare by one guide
How people manage it
- Take with food, as the Russian label directs

Who should avoid it, and what not to combine

Pregnancy and breastfeedingCondition
Listed as contraindications on the Russian supplement registration; guides say avoid.
Active or recent cancerCondition
A guide flags pinealon's effects on apoptosis and caspase-3 signalling.
Seizure disordersCondition
A guide urges caution with any compound acting on the brain.
Prescription brain or psychiatric medicationsSubstance
Interactions are not mapped. One guide lists melatonin, sedatives, immunosuppressants and serotonin-affecting antidepressants as theoretical interactions.
Under 14Condition
The Russian label is for adults from 14; a guide says there is no safety data in children and teens.

How much is known

Limited human data

Human data are a handful of Russian studies whose abstracts report no placebo arm: a two-week capsule course in train crew workers, 32 adults aged 41 to 83 with organic brain syndrome, and work-stress studies where it was given with vesugen. The rest is cell and rat work, mostly from the developers' group. ClinicalTrials.gov lists no trials.