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Some human trialsFormerly approved as Geref

Sermorelin side effects

Also known as: Sermorelin acetate · GRF 1-29 NH2 · GHRH (1-29) · Geref

Updated 20 sources

5 side effects reported for Sermorelin: 0 from studies and labels, 5 from users and guides. 2 come with the ways people manage them.

Sermorelin overview

Side effects users and guides report

What people post and what dosing guides list. These are reports, not measured rates.

From users and guides5

Community reports, competitor and vendor guides, media.

  • Facial flushing

    One of the two most commonly reported events in studies; transient. Exact rates were not in the abstract

  • Injection-site pain or redness

    One of the two most commonly reported events in studies. Guides see mild redness in weeks 1 to 2

  • Joint pain, swelling or carpal tunnel symptoms

    Treated by guides as stop signals, not as reported rates

    How people manage it

    • Guides check IGF-1, fasting insulin and HbA1c at baseline and at weeks 6 and 12, and titrate to upper-normal IGF-1 for age.

  • Raised fasting glucose

    Treated by guides as a stop signal

    How people manage it

    • Guides check fasting insulin and HbA1c at baseline and at weeks 6 and 12.

  • Hypersensitivity

    Treated by guides as a stop signal

How much is known

Some human trials

Historic FDA approval backed by pediatric GH-deficiency growth data over 12 to 36 months, plus diagnostic use. No body-composition trials in adults. Adult use rests on clinic practice and guide conventions.

Sources for these side effects

3 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Clinical study1

  1. Sermorelin review (Prakash & Goa 1999)PubMed · checked Oct 23, 2026

Competitor guide2

  1. Sermorelin dosage chartPeptidesExplorer · checked Oct 23, 2026
  2. Sermorelin dosage guideBodyHackGuide · checked Oct 23, 2026

Back to the full Sermorelin page for dosing, the vial chart and storage.