Animal data onlyNot FDA approved

5-Amino-1MQ side effects

Also known as: 5 amino 1mq · 5-Amino-1-methylquinolinium · 5-Amino-1-methylquinolinium iodide · 5A1MQ · 5-AMQ · 5-Am-1MQ · Amino 1MQ

Updated Oct 23, 202640 sources

11 side effects reported for 5-Amino-1MQ: 1 from studies and labels, 10 from users and guides. 3 come with the ways people manage them.

5-Amino-1MQ overview

Side effects reported in studies and labels

Rates as each trial or label states them. A rate from one trial does not carry over to research-grade vials or other doses.

From trials and regulators1

Clinical studies and regulatory documents.

No adverse effects seen in mice
None observed in the 11-day mouse obesity study, and food intake did not change. In a 28-day mouse study liver enzymes normalized. No human safety data exist.

Side effects users and guides report

What people post and what dosing guides list. These are reports, not measured rates.

From users and guides10

Community reports, competitor and vendor guides, media.

Alertness and trouble sleeping
One community report of staying up late after an evening dose. A competitor guide also lists sleep trouble.
How people manage it
- Take it in the morning instead of the evening or before an evening workout.
Fatigue
One community report of tiredness when dosed on consecutive days.
How people manage it
- The poster dropped to 3 days a week instead of daily dosing.
Frequent urination
One community report at 2.5 mg a day subcutaneous.
Yeast-flavored burps
One community report on oral dosing.
Sweating at high doses
A single unsupported claim in one community comment.
Mild stomach upset and loose stools
Listed by a competitor guide for the first week. Not sourced to any study.
Headache early on
Listed by a competitor guide. Not sourced to any study.
Feeling warm and a faster resting heart rate
Listed by a competitor guide. Not sourced to any study.
Injection site stinging
Listed by a competitor guide. Not sourced to any study.
How people manage it
- Some users switch to oral capsules, arguing a small molecule makes more sense taken by mouth.
Methylation (SAM) load, a theoretical worry
Raised in community threads, especially by people also taking NAD+. It is a concern, not a reported effect. In cells, blocking NNMT raised SAM.

How much is known

Animal data only

Cell studies, an 11-day mouse obesity study (20 mg/kg three times daily, about 5% weight loss), a 28-day mouse obesity and liver study, an aged-mouse muscle study (5 and 10 mg/kg a day, peak torque up about 70%) and a rat PK study. ClinicalTrials.gov lists zero human studies. Most papers come from one lab group, and the 2024 paper discloses commercial ties.