Limited human dataNot FDA approved

DSIP side effects

Also known as: Delta sleep-inducing peptide · Emideltide · Emideltide acetate · Deltaran

Updated Oct 23, 202670 sources

10 side effects reported for DSIP: 2 from studies and labels, 8 from users and guides. 5 come with the ways people manage them.

Sleep

DSIP overview

Side effects reported in studies and labels

Rates as each trial or label states them. A rate from one trial does not carry over to research-grade vials or other doses.

From trials and regulators2

Clinical studies and regulatory documents.

Sweating, headache, nausea or vertigo (IV trial)
9 of 107 patients in the 1984 IV withdrawal trial, short-lived, per FDA's review. 95 of 107 had no significant side effects.
Low blood pressure (IV trial)
In FDA's reading of the IV withdrawal trial, 3 of 107 had serious effects, including 2 with low blood pressure at the first injection.

Side effects users and guides report

What people post and what dosing guides list. These are reports, not measured rates.

From users and guides8

Community reports, competitor and vendor guides, media.

Morning grogginess
One guide claims 10 to 15% at 200 mcg and up, with no source. Community reports tie it mostly to doses above 200 to 300 mcg.
How people manage it
- Drop the dose, or start at 100 mcg and step up slowly.
- One guide says it usually clears within 30 minutes of waking.
Vivid dreams or nightmares
Commonly reported in community logs and r/Peptides posts. One guide claims 15 to 25% with no source.
How people manage it
- One r/Peptides user had nightmares on the nasal form and slept well after switching to subQ.
Headache
One guide claims 5 to 10% in the first 2 to 3 nights, unsourced. Logged 177 times across about 50 self-reports on one site, a count rather than a rate.
No noticeable effect
A common report on r/Peptides: users saw nothing after weeks of nightly use at doses from 200 mcg to 2.5 mg. Guides also say many feel little or nothing.
How people manage it
- Consumer sleep trackers stage sleep poorly, as r/Peptides replies point out, so tracker changes in either direction are weak evidence.
Feeling wired or sleeping worse
Several r/Peptides reports at 200 mcg: jitters like a pot of coffee, waking six times, sleepy but unable to sleep. Guides list paradoxical alertness, mainly at very low doses.
How people manage it
- Dose earlier. The one trial that measured timing saw a slight arousing effect in the first hour, and some users dose 2 to 3 hours before bed.
- One guide warns against dosing too close to bedtime.
Rebound insomnia after long daily runs
Reported in aggregated community notes after daily use beyond 2 to 3 weeks.
How people manage it
- Take nights off or cycle, for example 5 on and 2 off or 2 weeks on and 2 off, as r/Peptides users describe.
Injection site irritation, lumps or bruising
One guide claims about 5%, unsourced. One r/Peptides user got lumps and bruising at 250 mcg after several shots.
Nasal irritation (sprays)
Listed by guides for the nasal form. No rate given.

How much is known

Limited human data

A handful of small IV trials from 1981 to 1992, mostly 6 to 16 people, plus a 107-patient withdrawal trial and a 7-patient pain pilot. The positive sleep results come mostly from one group; two independent double-blind trials found little benefit. FDA calls the evidence inconclusive and notes no safety data for subQ use. No trials are registered on ClinicalTrials.gov.