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Limited human dataFDA status unclear

GHRP-2 and GHRP-6 side effects

Also known as: GHRP-2 · GHRP-6 · Pralmorelin · KP-102 · GPA-748 · GHRP Kaken 100 · Growth hormone-releasing hexapeptide · SKF-110679

Updated 28 sources

8 side effects reported for GHRP-2 and GHRP-6: 1 from studies and labels, 7 from users and guides. 3 come with the ways people manage them.

GHRP-2 and GHRP-6 overview

Side effects reported in studies and labels

Rates as each trial or label states them. A rate from one trial does not carry over to research-grade vials or other doses.

From trials and regulators1

Clinical studies and regulatory documents.

  • Injection-site reactions

    Reported across the class in a 2026 review

Side effects users and guides report

What people post and what dosing guides list. These are reports, not measured rates.

From users and guides7

Community reports, competitor and vendor guides, media.

  • Strong hunger (GHRP-6)

    Guides report sharp hunger starting 15 to 30 minutes after a shot and lasting 30 minutes to 2 hours

    How people manage it

    • Plan a meal 30 to 60 minutes after each shot, and avoid shots long before a meal.
    • Switch to GHRP-2 or ipamorelin if the hunger is unwanted.

  • More appetite (GHRP-2)

    Food intake rose 35.9% in 7 lean men during a subcutaneous infusion. Guides call the hunger milder than with GHRP-6

  • Cortisol and ACTH rise

    Both raised ACTH and cortisol in swine. In humans, GHRP-6 at 1 mcg/kg raised cortisol with no detectable side effects, and GHRP-2 triggered ACTH

    How people manage it

    • Guides check morning cortisol and prolactin if concerned.

  • Prolactin rise

    Reported across the class in a 2026 review. Guides describe a mild bump with GHRP-2

    How people manage it

    • Keep to 100 to 150 mcg and add a shot rather than raising the dose, per guides.

  • Blood sugar changes, fluid retention, muscle and joint aches

    Reported across the GHRP class in a 2026 review. Guides see water retention in weeks 1 to 2 on GHRP-6

  • Head rush or warm flush (GHRP-2)

    Reported by guides in the first minutes after a shot

  • Vivid dreams (GHRP-6)

    Guides report it within 3 to 5 days of starting bedtime doses

How much is known

Limited human data

Phase 1 and 2 studies plus diagnostic use, with no body-composition trials. In older adults, continuous GHRP-2 at 1 mcg/kg per hour for 30 days raised GH and IGF-1. GHRP-2 at 1 mcg/kg matched the GH response of GHRH plus a low GHRP-2 dose.

Sources for these side effects

11 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide6

  1. GHRP-6PeptidesExplorer · checked Oct 23, 2026
  2. GHRP-6PeptideDeck · checked Oct 23, 2026
  3. GHRP-6 dosage guideBodyHackGuide · checked Oct 23, 2026
  4. GHRP-2 vs GHRP-6PeptidesExplorer · checked Oct 23, 2026

Back to the full GHRP-2 and GHRP-6 page for dosing, the vial chart and storage.