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Limited human dataFDA status unclear

GHRP-2 and GHRP-6

Also known as: GHRP-2 · GHRP-6 · Pralmorelin · KP-102 · GPA-748 · GHRP Kaken 100 · Growth hormone-releasing hexapeptide · SKF-110679

Updated 28 sources

GHRP-2 and GHRP-6 are two six-amino-acid peptides that switch on the ghrelin (hunger hormone) receptor. That fires a GH pulse and, to different degrees, raises appetite, cortisol and prolactin. GHRP-2 gives more GH per mcg with milder hunger. GHRP-6 brings strong hunger, which is why bulkers like it. GHRP-2 is a licensed diagnostic drug in Japan; neither is approved in the US.
Calculate with GHRP-2 and GHRP-6Dosage chart

Quick facts

Half-life
  • GHRP-2: about 0.55 hours, with GH peaking around 60 minutes. GHRP-6: about 2.5 hours.
Routes
  • Subcutaneous injection
  • Other route
Reported dose ranges
  • 100 to 400 mcg (subcutaneous injection)
  • 100 mcg (other route)
Vial sizes
  • 2 mg, 5 mg, 10 mg
FDA status
  • FDA status unclear
WADA
  • Prohibited

What people use GHRP-2 and GHRP-6 for

  • A GH pulse for recomposition, sleep and recovery, usually paired with a GHRH analog
  • GHRP-6 for bulking, because of the hunger it drives
  • Men's clinic protocols alongside sermorelin and testosterone therapy
  • Medical testing: GHRP-2 as a GH and adrenal stimulation test in Japan

How it is thought to work. Both bind the ghrelin receptor on the pituitary and hypothalamus and trigger a GH pulse. Paired with a GHRH analog, the pulse is bigger than either gives alone. Unlike ipamorelin, both raised ACTH and cortisol in animals, and both activate the adrenal axis in humans strongly enough to be studied as adrenal tests. GHRP-6 came first, and the hunt for its receptor led to the discovery of ghrelin.

GHRP-2 and GHRP-6 dosing

13 protocols from studies, guides and community reports, grouped by goal. Tap a source badge to see where a number came from.

GHRP-23

GHRP-2: forum convention

Amount
100 to 150 mcg
How often
2 to 3 times daily, fasted
Route
Subcutaneous injection
Cycle
8 to 12 weeks
Timing and details

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GHRP-2: educational chart

Amount
100 to 300 mcg
How often
Once daily
Route
Subcutaneous injection

GHRP-2: diagnostic test dose

Amount
100 mcg
How often
A single IV dose for the test
Route
Other route
Timing and details

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GHRP-63

GHRP-6: forum convention

Amount
100 to 300 mcg
How often
2 to 3 times daily, fasted
Route
Subcutaneous injection
Cycle
8 to 12 weeks
Timing and details

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GHRP-6: educational chart

Amount
100 to 300 mcg
How often
300 to 900 mcg a day, split into 3 doses
Route
Subcutaneous injection
Timing and details

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GHRP-6: weight-based framing

Amount
100 to 300 mcg
How often
2 to 3 times daily, about 1 to 3 mcg/kg per shot
Route
Subcutaneous injection
Timing and details

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Other protocols: injected7

Self-logged doses (either peptide)

Amount
200 to 400 mcg
How often
Per logged entry; median bucket 200 to 400 mcg for both
Route
Subcutaneous injection
Timing and details

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Standard shot (either peptide)

Amount
100 mcg
How often
1 to 3 times daily; the bedtime shot matters most
Route
Subcutaneous injection
Cycle
12 to 16 weeks to judge; 5 on, 2 off for long-term use
Timing and details

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Advanced shot (either peptide)

Amount
150 to 200 mcg
How often
1 to 3 times daily
Route
Subcutaneous injection

5 days a week (either peptide)

Amount
100 to 300 mcg
How often
2 to 3 times daily, 5 days a week
Route
Subcutaneous injection
Cycle
4 to 8 weeks on
Rest
2 to 4 weeks off
Timing and details

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GHRP-2 with CJC-1295 no DAC (GHRP-2 amount; CJC 100 mcg)

Amount
100 to 200 mcg
How often
2 to 3 times daily
Route
Subcutaneous injection

GHRP-6 with CJC-1295 no DAC (GHRP-6 amount; CJC 100 mcg)

Amount
200 mcg
How often
2 to 3 times daily
Route
Subcutaneous injection
Cycle
12 to 16 weeks on
Rest
4 to 8 weeks off

Clinic regimen: GHRP-2 plus GHRP-6 plus sermorelin (each)

Amount
100 mcg
How often
3 times daily, GHRP-2 and GHRP-6 at 100 mcg each with sermorelin
Route
Subcutaneous injection
Cycle
Mean of 134 days in the review
Timing and details

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Doses shown are what sources report, labelled by origin. Not medical advice.

Full GHRP-2 and GHRP-6 dosage guideEvery titration step in syringe units, missed doses and how to mix.

Vial strengths and syringe units

Every GHRP-2 and GHRP-6 vial size with the water volumes sources use. Units are what to draw on a U-100 insulin syringe, worked out exactly.
GHRP-2 and GHRP-6: concentration and U-100 syringe units for each vial size and water volume
WaterStrength100 mcgdose, units200 mcgdose, units300 mcgdose, units
2 mg vial
2 mLCompetitor guide†1 mg/mL100.1 mL200.2 mL300.3 mL
3 mLCompetitor guide†0.667 mg/mL150.15 mL300.3 mL450.45 mL
5 mg vial
2 mLCompetitor guide2.5 mg/mL40.04 mL80.08 mL120.12 mL
3 mLCompetitor guide1.667 mg/mL60.06 mL120.12 mL180.18 mL
10 mg vial
2 mLCompetitor guide†5 mg/mL20.02 mL40.04 mL60.06 mL
3 mLCompetitor guide†3.333 mg/mL30.03 mL60.06 mL90.09 mL
Units are on a U-100 insulin syringe (100 units = 1 mL). U-50 and U-30 barrels read the same units.† Water volume sourced for a different vial size. The math is exact either way.Water volumes from

Doses shown are what sources report, labelled by origin. Not medical advice.

Calculate with this peptideYour vial, your water, your dose: GHRP-2 and GHRP-6 in syringe units, with the math shown.

What people report

What GHRP-2 and GHRP-6 users write on Reddit, counted post by post. These are reports, not measured rates or advice.

Community-reportedFrom 266 Reddit posts and comments, last mined Oct 23, 2026r/Biohackers, r/Peptides, r/Peptidesource, r/PeptideGuide

Doses people report for GHRP-2 and GHRP-6

Muscle growth7 mentions

Amounts reported for muscle growth, with mention counts
ReportedMentions
100 mcg4

Weight loss3 mentions

Amounts reported for weight loss, with mention counts
ReportedMentions
100 mcg3

How often

Dosing frequencies reported, with mention counts
ReportedMentions
Twice a day5
Once a day2

Most mentioned alongside

Side effects people mention

  • Extreme hunger4 mentions

  • Hives2 mentions

  • Flushing2 mentions

Doses shown are what sources report, labelled by origin. Not medical advice.

GHRP-2 and GHRP-6 side effects

What trials and labels report, kept apart from what users and guides report. Frequencies are worded as each source states them.

Reported in studies and labels1

From clinical trials and regulatory documents.

  • Injection-site reactions

    Reported across the class in a 2026 review

Reported by users and guides6

From community reports and dosing guides. Not measured rates.

  • Strong hunger (GHRP-6)

    Guides report sharp hunger starting 15 to 30 minutes after a shot and lasting 30 minutes to 2 hours

    How people manage it

    • Plan a meal 30 to 60 minutes after each shot, and avoid shots long before a meal.

  • More appetite (GHRP-2)

    Food intake rose 35.9% in 7 lean men during a subcutaneous infusion. Guides call the hunger milder than with GHRP-6

  • Cortisol and ACTH rise

    Both raised ACTH and cortisol in swine. In humans, GHRP-6 at 1 mcg/kg raised cortisol with no detectable side effects, and GHRP-2 triggered ACTH

    How people manage it

    • Guides check morning cortisol and prolactin if concerned.

  • Prolactin rise

    Reported across the class in a 2026 review. Guides describe a mild bump with GHRP-2

    How people manage it

    • Keep to 100 to 150 mcg and add a shot rather than raising the dose, per guides.

  • Blood sugar changes, fluid retention, muscle and joint aches

    Reported across the GHRP class in a 2026 review. Guides see water retention in weeks 1 to 2 on GHRP-6

  • Head rush or warm flush (GHRP-2)

    Reported by guides in the first minutes after a shot

All 8 GHRP-2 and GHRP-6 side effects and how people manage themEvery management tip, who should not use it, and side-effect questions.

Storage

Powder (before mixing)

Powder-specific guidance was not found in the sources, beyond general advice to refrigerate. The fridge guidance for mixed vials is the closest reference.

Mixed vial

Temperature
2 to 8 °C
Use within
28 days

Fridge, 2 to 8 °C, protected from light. Guides give 28 days, or say to follow the formulation's use-by.

Mixed with: Bacteriostatic water

Mixing. GHRP-2 comes in 5 and 10 mg vials; GHRP-6 in 2, 5 and 10 mg. 2 mL in a 5 mg vial is the common choice. A 10 mg CJC-1295 plus GHRP-2 blend is sold, but no water volume was found for it.

Stacks people report

Combinations from guides and community posts, with the reason given.
  • CJC-1295

    CJC-1295 no DAC at 100 mcg in the same shot. GHRP plus GHRH releases more GH than either alone.

  • Sermorelin

    A clinic regimen gave GHRP-2, GHRP-6 and sermorelin together, 3 times daily; IGF-1 rose from 159.5 to 239.0 ng/mL in 14 compliant men. Guides pair GHRP-6 with sermorelin before bed for bulking.

Compare GHRP-2 and GHRP-6

Evidence and legal status

Evidence: limited human data

Phase 1 and 2 studies plus diagnostic use, with no body-composition trials. In older adults, continuous GHRP-2 at 1 mcg/kg per hour for 30 days raised GH and IGF-1. GHRP-2 at 1 mcg/kg matched the GH response of GHRH plus a low GHRP-2 dose.

FDA and WADA

FDA status unclear

Sources do not settle the FDA status.

Neither is approved in the US. Both are in 503B Category 2 (added September 29, 2023). On the 503A lists dated May 14, 2026, both sit in Category 3, nominated without adequate support.

FDA's concerns: for GHRP-2, reports of serious events including deaths in critically ill study subjects, with causality not established; for GHRP-6, possible cortisol and blood-sugar effects; immunogenicity for both. GHRP-2 (pralmorelin) is marketed in Japan as a diagnostic agent. WADA 2026 names GHRP-2, GHRP-6 and hexarelin under S2.2.4, banned at all times.

WADA: Prohibited

GHRP-2 and GHRP-6 questions

GHRP-2 or GHRP-6: which should I pick?

GHRP-2 gives more GH per mcg with milder hunger. GHRP-6 brings strong hunger, which suits bulking and annoys everyone else.

How much per shot?

About 100 mcg, 2 to 3 times a day, is the center. Forum protocols run 100 to 150 mcg for GHRP-2 and up to 300 mcg for GHRP-6.

Why do guides stop at 100 mcg?

Guides say about 1 mcg/kg, roughly 100 mcg, gives near-maximal GH, and more adds side effects faster than GH. The data are softer than that: in older adults, 10 mcg/kg of GHRP-2 still roughly doubled GH compared with 1 mcg/kg. Saturation is not absolute.

How bad is GHRP-6 hunger?

Strong, starting within 15 to 30 minutes. Plan a meal around it.

Do they raise cortisol and prolactin?

Yes, modestly. That is the main difference from ipamorelin.

How much water for a 5 mg vial?

2 mL is common, giving 2.5 mg/mL. Use the calculator to turn your dose into syringe units.

Do I need to take them fasted?

Yes. Guides say 2 or more hours after food, then wait 20 to 30 minutes before eating.

How long is a cycle?

8 to 12 weeks in forum protocols, 12 to 16 weeks in some guides, often 5 days on and 2 off. One guide runs 4 to 8 weeks with 2 to 4 off.

Are they approved anywhere?

GHRP-2 (pralmorelin) is used as a diagnostic agent in Japan. Neither is approved in the US.

What do 503A Category 3 and 503B Category 2 mean here?

503B Category 2 is FDA's list of substances with significant safety concerns for outsourcing facilities. 503A Category 3 means the substance was nominated for pharmacy compounding without adequate support. Both peptides sit in both.

What about hexarelin?

A close relative with a half-life of about 55 minutes. In older adults on it twice daily, the GH response fell over 16 weeks and came back after 4 weeks off.

Is there a 10 mg GHRP-6 vial?

Yes, 10 mg vials are sold.

Are they banned in sport?

Yes. WADA names both under S2.2.4, banned at all times.

Ask about GHRP-2 and GHRP-6

Answers come from this site's pages only, with a link to each source.

Sources

28 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory3

  1. Certain bulk drug substances, safety risksFDA · checked Oct 23, 2026
  2. 503A bulk drug substance categories (May 14, 2026)FDA · checked Oct 23, 2026
  3. WADA Prohibited List 2026WADA · checked Oct 23, 2026

Competitor guide13

  1. GHRP-2 5 mg vialPeptideDosages · checked Oct 23, 2026
  2. GHRP-6 5 mg vialPeptideDosages · checked Oct 23, 2026
  3. GHRP-6 10 mg vialPeptideDosages · checked Oct 23, 2026

Community-reported3

  1. Performance-enhancing peptides modulating GH-IGF1 axis (Dominikowski 2026)PMC · checked Oct 23, 2026
  2. GHRP-2 (self-logged doses)PeptIQ · checked Oct 23, 2026
  3. GHRP-6 (self-logged doses)PeptIQ · checked Oct 23, 2026