Oxytocin news and clinical trials

New randomized trial in Women's health (London, England): Oxytocin selectively enhances the recognition of infant sadness in postpartum depression.

University Hospital, Clermont-Ferrand terminated a Phase 4 randomized controlled trial comparing balloon catheter plus oxytocin to oral misoprostol for labor induction in nulliparous women due to futility.

Ankara City Hospital Bilkent is planning an observational study of 120 pregnant women to compare how dural puncture epidural analgesia affects maternal plasma oxytocin levels during early versus late stages of labor.

Wake Forest University Health Sciences terminated a 4-participant study on the pharmacodynamics of oxytocin for chronic knee pain. The study was stopped due to funding and competing NIH grant work.

Istanbul University-Cerrahpasa registered a trial of 136 participants to evaluate the effects of various massage techniques on breastfeeding and mother-infant bonding. The study compares maternal and infant massage, oxytocin massage, or both against standard care.

Assiut University registered a 100-participant study to examine the effect of intravenous oxytocin on post-dural puncture headache following cesarean sections. The study is not yet recruiting.

The University of Electronic Science and Technology of China is recruiting 120 healthy adults for an fMRI study. Researchers will evaluate how oromucosal oxytocin and arginine vasopressin affect attention to emotional faces compared to a placebo.

The University of Electronic Science and Technology of China is recruiting 80 healthy adult participants to study how 24 IU of intranasal oxytocin modulates fairness perception and prosocial behaviors.

In a randomized clinical trial of 66 mothers, researchers found limited evidence for an association between oxytocin biomarkers and maternal bonding problems. Changes in oxytocin DNA methylation and hormone levels were observed during the first postpartum year.

New systematic review in Alpha psychiatry: The Effect of Intranasal Oxytocin on Social Interaction in Adults and Children With Autism Spectrum Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Melisa Gündeş completed a study of 80 midwifery students to evaluate the impact of simulation-based training on oxytocin induction. The study compared students who received theoretical training alone versus those who received additional simulation-based training.

Khyber Girls Medical College registered a trial comparing oxytocin quick injections versus slow infusions in 60 women undergoing caesarean section. The study aims to determine which method minimizes blood pressure drops and heart changes while ensuring effective uterine contraction.

This Cochrane systematic review aims to assess the effects of discontinuing intravenous oxytocin stimulation during the active phase of labour compared to continued administration. The study examines outcomes such as cesarean section rates, maternal infection, and neonatal health.

Selcuk University registered a study on an AI-based, oxytocin-stimulated smart lactation vest for 76 participants. The device uses thermo-massage and vibration to support milk flow and help prevent duct obstruction.

The Icahn School of Medicine at Mount Sinai completed a phase 3 trial comparing misoprostol and pitocin for labor induction in 303 obese patients. Both medications were used in combination with a foley catheter to evaluate effectiveness in inducing labor.

The University Hospital in Basel registered an observational study to compare endogenous neurophysin-I secretion in 30 premenopausal and postmenopausal women. The researchers hypothesize that cumulative oxytocin system release is lower in postmenopausal participants.

Yale University is launching a Phase 2 trial with 75 participants to investigate if intranasal oxytocin (TNX-1900) can lessen pain in patients undergoing pituitary surgery by altering emotional and social processing.

An intervention study of 62 older adults found that salivary oxytocin concentrations increased after a 13-week multimodal program designed to alleviate loneliness. Baseline oxytocin levels were lower in individuals reporting more intense loneliness.

An analysis of a randomized trial involving 284 women found that discontinuing oxytocin at the start of active labor was associated with improved fetal heart rate patterns and reduced uterine activity. This suggests a potential reduction in fetal stress.

A 12-week randomized trial of intranasal oxytocin for alcohol use disorder found no significant difference in the percentage of heavy drinking days compared to placebo. While oxytocin was well-tolerated, it did not significantly reduce drinking or alcohol-related outcomes.

Hayatabad Medical Complex registered a clinical trial of 262 participants to compare the hemodynamic effects of intravenous oxytocin bolus versus infusion during cesarean section under spinal anesthesia. The study aims to minimize side effects like hypotension and tachycardia.

Stony Brook University registered a phase 4 trial to compare the effectiveness of oxytocin bolus versus infusion in 180 patients at high risk for postpartum hemorrhage during elective cesarean sections. The study will measure uterine tone, maternal side effects, blood loss, and patient satisfaction.

Icahn School of Medicine at Mount Sinai's study NCT02225600 is listed as suspended (reason given: Study was halted during COVID pandemic. However, PI is currently reconnecting with a compounding pharmacy to…).

In a pilot study of 18 individuals with borderline personality disorder, researchers found that intranasal oxytocin was associated with higher scores on the imagination dimension of compassion-based meditation compared to a placebo.

A quality-improvement study of 1,094 vaginal births found that a high-rate prophylactic oxytocin infusion (500 mL/h) resulted in lower median quantitative blood loss compared to intermediate or low infusion rates.

New systematic review in Frontiers in cognition: Music's context-dependent influence on oxytocin, social bonding, and emotion regulation: a systematic review.

Researchers conducted a systematic review of 14 studies involving 5,624 participants to examine links between childhood adversity and mental illness. The review found that individuals with severe mental illnesses consistently showed higher childhood trauma scores and often had lower oxytocin levels.

A meta-analysis of six randomized clinical trials found no evidence that intranasal oxytocin consistently benefits alcohol-related outcomes. Researchers concluded that despite early expectations, there is no credible therapeutic effect for treating alcohol use disorder.

University Hospital, Montpellier completed an observational study with 40 participants investigating the developmental origins of endometriosis. Researchers compared anogenital distance, basal testosterone, and oxytocin levels between groups with and without endometriosis.

Researchers conducted a randomized controlled trial in 100 healthy males to see how intranasal oxytocin (24 IU) affects inhibitory control. The study found that oxytocin modulated neural processing through multi-stage mechanisms rather than acting as a general anxiety reducer.

The University of Washington posted results for a phase 2 trial involving 121 participants that examined whether oxytocin nasal spray enhances social safety learning in adults with social phobia compared to healthy volunteers. The study investigated the hormone's role in fear and social interaction.

A meta-analysis of 28 randomized controlled trials with 1,361 participants evaluated the effects of oxytocin administration on EEG measures. The study found small, statistically significant effects of oxytocin on neural activity, though results varied significantly across studies.

A systematic review of ten studies indicates that oxytocin functions as a context-dependent pain modulator rather than a universal analgesic. While results varied by pain type, the treatment showed a favorable safety profile with generally mild adverse effects.

Mansoura University is recruiting for a 332-participant study comparing carbetocin monotherapy to carbetocin combined with oxytocin infusion in elective cesarean sections. The trial aims to see if monotherapy is non-inferior at preventing blood loss.

Zhejiang University completed a phase 2 trial investigating the efficacy of oxytocin nasal spray for preventing postoperative delirium in 227 elderly orthopedic surgery patients. The protocol involved administering 24 IU doses before surgery and twice daily postoperatively.

Wake Forest University Health Sciences completed a 24-participant phase 2 trial testing the analgesic effects of intravenous and intranasal oxytocin compared to placebos against noxious heat pain. Researchers aimed to determine if patient age, weight, or sex influenced drug efficacy.

Tokat Gaziosmanpasa University registered a randomized controlled trial of 128 mothers to evaluate if oxytocin massage improves breastfeeding self-efficacy and the milk ejection reflex in those with insufficient milk production. The non-pharmacological intervention targets the thoracic region.

A randomized trial of 68 women undergoing elective cesarean delivery found that initiating oxytocin infusion at the time of skin incision led to lower blood loss and reduced hemoglobin decline compared to initiating infusion after fetal head delivery.

A study of 72 psychiatric inpatients examined whether intranasal oxytocin improves treatment outcomes based on baseline inflammation levels. Oxytocin administration was associated with greater improvement in depression outcomes only for patients with low baseline inflammation.

A randomized controlled trial of 126 primiparous women found that adding intravenous papaverine to oxytocin for labor induction did not shorten time to active labor. However, the papaverine group experienced lower rates of cesarean delivery for failed induction and shorter postpartum hospital stays.

A meta-analysis of 42 trials with 1922 participants found that intranasal oxytocin had a small, non-significant overall effect on symptoms of various mental disorders. However, researchers noted a promising, small significant effect specifically within schizophrenia spectrum disorders.

Researchers published a systematic review and meta-analysis of three randomized controlled trials involving 269 participants comparing carbetocin and oxytocin. Carbetocin showed a significant reduction in the incidence of postpartum hemorrhage compared to oxytocin in women with obesity.

The CMH Multan Institute of Medical Sciences registered a randomized controlled trial of 60 participants to compare the efficacy of 10 IU intra-umbilical oxytocin versus 10 IU intravenous oxytocin in reducing blood loss during the third stage of labor.

Massachusetts General Hospital registered an interventional pilot trial to test if oral estrogen and progestin stimulate endogenous oxytocin release in 20 youth. The study aims to identify a potential provocation test for diagnosing oxytocin deficiency in patients with hypopituitarism.

A study of 65 healthy female volunteers found that intranasal oxytocin (40 IU) can modulate the subjective perception of pain, fear, and aversive memory. Results showed that while it increased dislike of pain in aversive contexts, it also reduced the frequency of intrusive aversive memories.

The University of Electronic Science and Technology of China registered an interventional study of 80 healthy participants to investigate whether intranasal oxytocin modulates real-time fMRI neurofeedback training by facilitating the use of an interoceptive strategy.

The University Hospital, Basel, Switzerland, registered a 40-participant interventional study to test whether the oxytocin response to MDMA administration differs between adults with autism spectrum disorder and matched healthy controls.

Researchers published a systematic review comparing oxytocin alternatives for postpartum hemorrhage, finding no significant difference in blood loss for vaginal births but significant variances in cesarean births. The authors noted the results are indicative rather than conclusive.

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau registered a 80-participant clinical trial to evaluate the effectiveness of combining a 5-week self-compassion training program with intranasal oxytocin for treating borderline personality disorder.

A randomized trial of 100 women compared the effects of oxytocin and carbetocin after vaginal delivery. Researchers found both drugs have comparable effects on hemostatic parameters and efficacy with no significant side effects.

In a randomized study of 45 mothers with postpartum depression, researchers found that intranasal oxytocin increased maternal positive regard for the child and positive affect. However, oxytocin had no effect on maternal sensitivity, negative mood, or physiological stress responses.

The Medical University of South Carolina completed a phase 2 study involving 175 participants investigating the efficacy of 40 IU intranasal oxytocin versus placebo in reducing symptoms of alcohol use disorder and PTSD. The study utilized fMRI to evaluate potential neurobiological changes.

Researchers performed a randomized controlled pilot study with 55 participants to evaluate the feasibility of coadministering 500 mg of oral calcium carbonate with synthetic oxytocin during labor. The authors concluded the study was feasible, with high participant adherence.

New randomized trial in International journal of obesity (2005): Reproductive hormone stability with prolonged intranasal oxytocin in adults with obesity.

A randomized study of 18 adult males found that intranasal oxytocin administration and social observation independently affect time perception and motor performance. Participants produced longer time intervals with oxytocin, while observers led to shortened intervals and decreased force.

A systematic review and meta-analysis of 55 neuroimaging studies found that intranasal oxytocin has gender-dependent effects on amygdala activity. Oxytocin inhibited amygdala activity in males but enhanced it in females during response to emotional stimuli.

A randomized controlled trial examined the effects of intranasal oxytocin on gut health in autistic children. While the four-week regimen did not change bacterial diversity, it improved stool consistency and increased the abundance of the anti-inflammatory genus Fusicatenibacter.

A phase 1 study evaluated an inhaled oxytocin delivery system in 20 healthy female participants using a physiologically-based pharmacokinetic model. The inhaled doses were well-tolerated and produced pharmacokinetic profiles consistent with intramuscular dosing.

Assistance Publique - Hôpitaux de Paris terminated a 1721-participant trial investigating the combined use of oxytocin and misoprostol to prevent postpartum hemorrhage. The trial was halted prematurely due to futility.

Elizabeth Austen Lawson completed a pilot study of 28 participants investigating oxytocin response to oral Estrogen-progestin in adults with arginine-vasopressin deficiency. The study examined potential links between oxytocin levels and symptoms of anxiety, depression, and social difficulties.