Also known as: PEGylated mechano growth factor · Pegylated MGF · PEG MGF · Mechano growth factor pegylated
Updated 20 sources
Every PEG-MGF protocol on file, 10 in all, labelled by where each number came from. 1 have titration steps, each step is worked out in U-100 units for a 2 mg vial + 1 mL water.
Who: Bodybuilding forum protocols compiled in a 2026 peer-reviewed review
Timing: After training, under the skin or into the muscle.
Note: The same forum table lists a loading ladder of 100 mcg for 2 weeks, 200 mcg for 2 weeks, then 300 mcg for 4 weeks, and a maintenance figure of 200 to 400 mcg a day. The review warns these figures are forum practice, not validated doses, and that robust human trials are lacking.
Who: Community protocol aggregated from forum and Reddit reports
Timing: Within 30 minutes after training, into belly fat.
Who: Community protocol aggregated from forum and Reddit reports
Timing: 4 to 8 hours after training, into the muscles just trained. Some split the dose across several muscles.
Who: Community protocol aggregated from forum and Reddit reports
Note: A low start to check tolerance before going up.
Who: Community protocol aggregated from forum and Reddit reports
Note: Usually run next to BPC-157 or TB-500.
Timing: Post-workout, into or near the muscle group trained.
Note: At 600 mcg a week, the guide says a 2 mg vial lasts about 10 doses, a little over 3 weeks.
Note: The same page's protocol table shows 100 to 250 mcg once daily and lists gut and joint uses, which reads like a template shared with unrelated peptides.
Note: The guide adds that no human clinical validation exists for any protocol.
Timing: On days off from training, to keep it apart from the body's own post-exercise MGF pulse.
Note: The guide says this timing rationale has not been validated.
| When | Dose | U-100 units (2 mg vial + 1 mL water) |
|---|---|---|
| Weeks 1 to 2 | 200 mcg | 10 units · 0.1 mL |
| Weeks 3 to 4 | 300 mcg | 15 units · 0.15 mL |
| Weeks 5 to 6 | 400 mcg | 20 units · 0.2 mL |
| Weeks 7 to 8 | 500 mcg | 25 units · 0.25 mL |
Note: Daily shots put the weekly total far above every other guide's 2 to 3 shots a week. No other source backs daily PEG-MGF outside a short injury phase.
Doses shown are what sources report, labelled by origin. Not medical advice.
| Water | Strength | 200 mcgdose, units | 300 mcgdose, units | 400 mcgdose, units |
|---|---|---|---|---|
| 2 mg vial | ||||
| 1 mLCompetitor guide | 2 mg/mL | 100.1 mL | 150.15 mL | 200.2 mL |
| 2 mLCompetitor guide | 1 mg/mL | 200.2 mL | 300.3 mL | 400.4 mL |
| 3 mLCompetitor guide | 0.667 mg/mL | 300.3 mL | 450.45 mL | 600.6 mL |
| 5 mg vial | ||||
| 2 mLCompetitor guide | 2.5 mg/mL | 80.08 mL | 120.12 mL | 160.16 mL |
| 2.5 mLCompetitor guide | 2 mg/mL | 100.1 mL | 150.15 mL | 200.2 mL |
Doses shown are what sources report, labelled by origin. Not medical advice.
Calculate with this peptideYour vial, your water, your dose: PEG-MGF in syringe units, with the math shown.Diluent: Bacteriostatic water
Water volumes sources use: 1 mL, 2 mL, 2.5 mL, 3 mL
Swirl, never shake; the solution should be clear and colourless. With 2 mL in a 2 mg vial, a 200 mcg dose is 20 units on a U-100 syringe. 3 mL is the most a 2 mg vial holds and gives bigger, easier draws for daily dosing plans.
A PEGylated version of mechano growth factor, the E-domain end of an IGF-1 splice variant (IGF-1Ec) that muscle switches on after heavy loading or damage. The PEG chain is meant to keep it stable and in circulation longer. It is sold for research only.
Plain MGF is gone within minutes, so people inject it daily, right after training, near the muscle they want to target. PEG-MGF is designed to last longer and spread through the body, so protocols drop to 2 or 3 shots a week at any under-the-skin site. The trade-off guides mention: less local action.
Forum protocols use 200 to 400 mcg, 2 to 3 times a week, with beginners at 100 to 200 mcg. PeptIQ app users most often log 200 to 400 mcg per shot, with reports up to 600 mcg. Use the calculator to turn a dose into syringe units for your vial.
Most protocols inject after training, from within 30 minutes for shots under the skin to 4 to 8 hours for shots into the muscle. Some guides prefer rest days instead, to stay clear of the body's own MGF pulse after exercise. None of these timings has been tested.
Guides use 1, 2 or 3 mL of bacteriostatic water. At 2 mL the vial is 1 mg/mL, so 200 mcg is 20 units on a U-100 insulin syringe.
Nobody knows. A 2026 review of these peptides found no reported half-life for PEG-MGF. Guide figures run from several hours to about 1 day to about 5 days, and none cites a measurement. Plain MGF lasts minutes.
The evidence is split and all of it is preclinical. In 2002 cell work the MGF E-domain made myoblasts multiply, and E-domain peptide protected heart muscle after heart attacks in sheep and mice. In 2014, two drug-company labs tried to reproduce the muscle-cell effect with native and stabilized MGF peptide and found nothing at up to 500 ng/ml, which led them to question whether MGF has a physiological role at all.
None. ClinicalTrials.gov lists no PEG-MGF or MGF trial, a 2026 review found no peer-reviewed human study, and FDA says it has found no human exposure data by any route.
Faster recovery between sessions is the most common report. Muscle gains are described as modest and gradual over 6 to 10 weeks, people say it works better stacked with IGF-1 LR3 or GH, and many find little benefit from it alone. These are anecdotes, not trial results.
Forum tables run 8 to 16 weeks with about 4 weeks off. Most guides run 4 to 8 weeks, and community protocols 6 to 10.
Not always. A doping lab found that two black-market MGF products were an amidated MGF analogue, not human MGF. Another lab found MGF inside vials sold as follistatin 344. PEGylation also adds a manufacturing step that labels cannot show.
No. It is listed among bulk substances once in FDA's 503A Category 2 whose nominations were withdrawn, and FDA's summary notes no human exposure data. Plain MGF is in Category 3, nominated without adequate support.
Yes. WADA lists mechano growth factors under S2.3, banned in and out of competition.
It is the most common pairing in community reports, PEG-MGF for repair signalling and LR3 for direct IGF-1 receptor action. No study has tested the pair.
6 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.
Back to the full PEG-MGF page for side effects, storage, stacks and legal status.