First human trial starting dose
Who: Men with metastatic prostate cancer and obesity (BMI over 30) in a Phase 1 dose-escalation trial at MD Anderson. Up to 5 dose levels were planned; 4 people enrolled.
Note: This was only the starting level of a trial that was terminated with no results posted. It is not a proven safe or effective dose. The protocol required good kidney function and banned NSAIDs and other kidney-stressing drugs.