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Animal data onlyNot FDA approved

Adipotide

Also known as: FTPP · Fat-Targeted Proapoptotic Peptide · Prohibitin-TP01 · Prohibitin Targeting Peptide 1 · CKGGRAKDC-GG-D(KLAKLAK)2

Updated 33 sources

Adipotide (FTPP, prohibitin-TP01) is a designed peptide that homes to the blood vessels feeding white fat and switches on cell death there, so the fat loses its blood supply. Obese monkeys lost 7 to 15% of body weight in 4 weeks. The same study found dose-dependent kidney changes that mostly reversed after stopping. A first human trial was terminated after 4 patients with no results posted, so every human dose in use today comes from community practice.
Calculate with AdipotideDosage chart

Quick facts

Routes
  • Subcutaneous injection
Forms
  • Vial (powder)
Reported dose ranges
  • 0.03 to 0.07 mg/kg (subcutaneous injection)
  • 250 to 1,000 mcg (subcutaneous injection)
  • 0.1 to 5 mg (subcutaneous injection)
Vial sizes
  • 1 mg, 2 mg, 5 mg, 10 mg
Chemistry
  • 2,557.2 g/mol · C111H206N36O28S2 · CAS 859216-15-2
FDA status
  • Not FDA approved
WADA
  • Not confirmed

What people use Adipotide for

  • Fat loss, especially stubborn belly and love-handle fat, usually as a short 2 to 4 week run
  • A finisher at the end of a cut, often next to retatrutide or tirzepatide
  • Body recomposition in experienced self-experimenters who track kidney labs

How it is thought to work. Two parts in one molecule. The cyclic CKGGRAKDC head binds prohibitin, a protein found on the inner lining of blood vessels in white fat. The D(KLAKLAK)2 tail is a membrane-disrupting sequence that triggers apoptosis once inside those cells. Losing their vessels, fat cells die and are cleared. Obese monkeys also ate less on it, and lean monkeys given the same dose did not lose weight.

Adipotide dosing

7 protocols from studies, guides and community reports, grouped by goal. Tap a source badge to see where a number came from.

Injected7

First human trial starting dose

Amount
0.03 mg/kg
How often
Once daily
Route
SubQ, vial (powder)
Cycle
One 28-day cycle
Timing and details

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Gradual titration (competitor guide)

Amount
250 to 1,000 mcg
How often
Once daily, rising 250 mcg every 2 weeks
Route
SubQ, vial (powder)
Cycle
4 to 8 weeks
Titration (4 steps) and details

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Low dose, three days a week (competitor guide)

Amount
0.1 mg
How often
0.1 mg on Monday, Wednesday and Friday (0.3 mg a week)
Route
SubQ, vial (powder)
Timing and details

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Short low-dose run (community)

Amount
0.3 to 1 mg
How often
Once daily; one user splits 670 mcg into two shots
Route
SubQ, vial (powder)
Cycle
15 to 20 days per run
Timing and details

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Mid dose, about 4 weeks (community)

Amount
2 to 3 mg
How often
Once daily
Route
SubQ, vial (powder)
Cycle
About 28 to 30 days
Rest
At least 4 weeks off
Timing and details

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High dose, short run (community)

Amount
4 to 5 mg
How often
Once daily, or 5 days on and 2 off
Route
SubQ, vial (powder)
Cycle
About 3 to 4 weeks
Timing and details

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Weight-based (community)

Amount
0.03 to 0.07 mg/kg
How often
Once daily
Route
SubQ, vial (powder)
Timing and details

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Doses shown are what sources report, labelled by origin. Not medical advice.

Full Adipotide dosage guideEvery titration step in syringe units, missed doses and how to mix.

Vial strengths and syringe units

Every Adipotide vial size with the water volumes sources use. Units are what to draw on a U-100 insulin syringe, worked out exactly.
Adipotide: concentration and U-100 syringe units for each vial size and water volume
WaterStrength0.1 mgdose, units250 mcgdose, units1,000 mcgdose, units
1 mg vial
1 mLCompetitor guide1 mg/mL100.1 mL250.25 mL1001 mL
2 mg vial
0.6 mLCompetitor guide3.333 mg/mL30.03 mL7.50.075 mL300.3 mL
5 mg vial
1.5 mLCompetitor guide3.333 mg/mL30.03 mL7.50.075 mL300.3 mL
All 4 vial sizes on the dosage chart (1 more)
Units are on a U-100 insulin syringe (100 units = 1 mL). U-50 and U-30 barrels read the same units.Water volumes from

Doses shown are what sources report, labelled by origin. Not medical advice.

Calculate with this peptideYour vial, your water, your dose: Adipotide in syringe units, with the math shown.

Adipotide side effects

What trials and labels report, kept apart from what users and guides report. Frequencies are worded as each source states them.

Reported in studies and labels4

From clinical trials and regulatory documents.

  • Kidney tubule changes (monkeys)

    Dose-dependent in all three monkey species tested. Serum creatinine rose at doses above 0.25 mg/kg; urine showed glucose and protein; mostly reversed within 28 days of stopping.

    How people manage it

    • The study authors called it predictable and reversible. One treated monkey per study still had a slight creatinine and urine glucose rise at the end of recovery.

  • More urine and mild dehydration (monkeys)

    Treated monkeys produced more urine; mild dehydration at the highest doses

  • Lower phosphorus and potassium (monkeys)

    Mild to moderate, time- and dose-dependent drops in serum levels

  • Eating less (monkeys)

    Weight loss came with lower food intake; no overt nausea or vomiting seen

Reported by users and guides5

From community reports and dosing guides. Not measured rates.

  • Frequent urination and thirst

    Reported by several Reddit users

    How people manage it

    • Users drink extra water, one aiming for at least 80 oz a day, and add electrolytes.

  • Injection-site burning and itching

    One daily log reports a few minutes of burning and itch after most shots, easing over the run

    How people manage it

    • That user found shots placed lower on the belly itched less.

  • Flushing, fatigue or headache

    One Reddit user, after the first shot taken fasted

    How people manage it

    • The user ate a meal and took electrolytes, mainly potassium, and later dosed only in a fed state.

  • High blood urea nitrogen

    One user after 5 mg a day for 21 days; rest of the metabolic panel normal

    How people manage it

    • Community advice: run kidney labs before, during and right after a run, compare to your own baseline, skip heavy exercise for 5 days before the draw, and add cystatin-C.

  • Uneven fat loss (small dips under the skin)

    One user after 2 mg a day for 30 days

All 9 Adipotide side effects and how people manage themEvery management tip, who should not use it, and side-effect questions.

Who should avoid it

  • Kidney disease or reduced kidney functionCondition

    Kidney tubule injury was the main finding in monkeys, and the human trial only enrolled people with near-normal creatinine and less than 2,000 mg of urine protein a day.

  • NSAIDs and other kidney-stressing drugsSubstance

    The human trial barred NSAIDs, IV vancomycin, aminoglycosides and other strongly nephrotoxic drugs from consent until 30 days after the last dose; low-dose aspirin (81 mg or less) was allowed.

  • Uncontrolled high blood pressure or diabetesCondition

    Both were exclusions in the human trial, because they can hide existing kidney damage.

Storage

Powder (before mixing)

Temperature
-20 °C

Freezer at -20 °C, dry and dark. One vendor says the powder keeps up to 24 months frozen.

Mixed vial

Temperature
2 to 8 °C
Use within
7 to 30 days

Fridge at 2 to 8 °C, protected from light, no freeze-thaw. Guides disagree on the window: 7 to 14 days on one, 30 days on another.

Mixed with: Bacteriostatic water

Mixing. The peptidedosages charts scale the water to the vial so every size lands near 3.33 mg/mL. Inject the water down the vial wall and swirl, do not shake.

Stacks people report

Combinations from guides and community posts, with the reason given.
  • Retatrutide

    The most common pairing on Reddit: adipotide as a short finisher on top of a retatrutide cut. Some users push back that stacking makes it impossible to tell what adipotide did.

  • AOD-9604

    Paired by users chasing stubborn love-handle fat, one at 300 mcg adipotide a day.

  • KLOW

    One user runs KLOW and adipotide together in the evening, 5 days on and 2 off, next to retatrutide.

  • Tirzepatide

    Added with retatrutide for a 4-week high-deficit finisher alongside 3 mg adipotide.

Compare Adipotide

Evidence and legal status

Evidence: animal data only

Mice: about 30% weight loss in 4 weeks with fat ablation (2004). Obese rhesus monkeys: 0.43 mg/kg daily for 28 days cut body weight 7.4 to 14.7% and total body fat 38.7% by the end of recovery, and improved insulin resistance; lean monkeys did not lose weight; kidney tubule changes were dose-dependent and mostly reversible. Humans: no results exist. The one Phase 1 trial was terminated after 4 participants and posted nothing.

FDA and WADA

Not FDA approved

No approval, no trial program and not on FDA's compounding lists.

Not FDA approved for any use. Its only human trial, a Phase 1 study at MD Anderson in obese men with advanced prostate cancer (NCT01262664), was terminated at the investigator's request after enrolling 4 people, with no results posted. It is not on FDA's 503A nominated-substance lists or its compounding safety-risk page.

WADA does not name adipotide on its 2026 List, and it fits none of the named classes. The S0 catch-all bans at all times any substance with no human therapeutic approval, including discontinued drug candidates, which on its plain wording could include adipotide. No source rules on it directly, so we mark it unknown. FDA has never assessed it for compounding, so its absence from those lists means it was never reviewed.

WADA: Not confirmed

Adipotide questions

What is adipotide?

A designed peptide, also called FTPP or prohibitin-TP01, built at MD Anderson. One end homes to the blood vessels of white fat, the other end triggers cell death, so fat tissue loses its blood supply.

What does adipotide do?

In obese monkeys it caused rapid weight loss, a 38.7% drop in total body fat by the end of a 4-week recovery, and better insulin sensitivity. In mice it reversed obesity. None of this has been shown in people.

How much weight did the monkeys lose?

In the fixed-dose study, 10 obese rhesus monkeys on 0.43 mg/kg a day for 4 weeks lost 7.4 to 14.7% of body weight, while controls changed between +1.0 and -3.5%. Press coverage rounded this to about 11%.

Does adipotide hurt your kidneys?

Kidney changes were the main side effect in monkeys: higher creatinine above 0.25 mg/kg, glucose and protein in the urine, and small tubule lesions. Most of it reversed within 28 days of stopping, and the authors called it mild, predictable and reversible. No human kidney data were ever published.

Has adipotide been tested in humans?

Once. A Phase 1 trial at MD Anderson in obese men with advanced prostate cancer started at 0.03 mg/kg a day for 28 days. It was terminated at the investigator's request after 4 people enrolled, and no results were posted.

What dose do people use?

There is no proven human dose. A competitor chart climbs from 250 mcg to 1 mg a day over 8 weeks. Reddit users report 300 mcg to 1 mg a day for 2 to 3 weeks, 2 to 3 mg a day for about 4 weeks, and a few go to 4 or 5 mg.

How do I reconstitute a 10 mg vial?

The common choice is 3 mL of bacteriostatic water, about 3.33 mg/mL. On a U-100 syringe, 1 unit is then about 33 mcg, so 250 mcg is 7.5 units and 1 mg is 30 units.

How long is an adipotide cycle?

Short. The monkey study and the human trial both ran 28 days. Community runs are 15 to 30 days, often followed by at least 4 weeks off. A competitor chart goes to 8 weeks.

Is adipotide FDA approved?

No. It has no approval, and FDA has never reviewed it for compounding: it is absent from the 503A nominated-substance lists and the compounding safety-risk page.

Is adipotide banned in sport?

WADA does not name it on the 2026 List. Its S0 class bans any substance with no human therapeutic approval at all times, including discontinued drug candidates, and on plain wording that could include adipotide. No ruling addresses it directly, so we list its status as unknown. A tested athlete would be relying on S0 not applying.

What do people on Reddit say about adipotide?

Opinion is split. Many users warn against it because of the monkey kidney findings, and some own it but will not use it. Users who have run it mostly report frequent urination and normal or near-normal labs, and they stress hydration and kidney bloodwork.

What labs do users check?

Creatinine and BUN on a metabolic panel before, during and right after a run, plus cystatin-C, compared against your own baseline. Some also dip urine strips for glucose and protein daily, the same changes seen in the monkeys.

Did lean monkeys lose weight?

No. Lean rhesus monkeys at 0.25 and 0.43 mg/kg kept their weight, and the high-dose group held steady or lost a little. The authors suggest the effect may be specific to obesity.

Is adipotide the same as AOD-9604?

No. AOD-9604 is a fragment of growth hormone. Adipotide is an unrelated peptide that targets the blood vessels of fat.

Why did the human trial stop?

The registry only says it was terminated at the investigator's request. No reason or results were posted, so claims that it stopped over human kidney damage are not backed by the record.

Ask about Adipotide

Answers come from this site's pages only, with a link to each source.

Sources

33 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Reference work1

  1. Adipotide (CID 163360068) computed propertiesPubChem · checked Oct 24, 2026

Vendor guide1

  1. Adipotide 10 mg product pageVendor product page · checked Oct 24, 2026

Competitor guide6

  1. Adipotide protocol guidepathtopeptides.com · checked Oct 24, 2026
  2. Adipotide (2 mg Vial) Dosage Protocolpeptidedosages.com · checked Oct 24, 2026
  3. Adipotide (5 mg Vial) Dosage Protocolpeptidedosages.com · checked Oct 24, 2026

Community-reported19

  1. Post: 670 mcg a day from a 10 mg / 3 mL vialReddit r/PeptideDiscussion · checked Oct 24, 2026
  2. Comment: 300 mcg daily alongside AOD-9604Reddit r/BodyHackGuide · checked Oct 24, 2026
  3. Post: 6 months progress and stack, adipotide 0.5 mg a day for 20 daysReddit r/Retatrutide · checked Oct 24, 2026