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Some human trialsIn clinical trials

Eloralintide

Also known as: LY3841136 · LY-3841136 · Elora

Updated 23 sources

Eloralintide is Eli Lilly's once-weekly amylin drug, built to favor the amylin 1 receptor instead of hitting amylin and calcitonin receptors the way cagrilintide does. In a 48-week phase 2 trial it cut weight by 9% at 1 mg up to 20% at 9 mg. It lasts about two weeks in the body. It is in phase 3 and not approved anywhere, and Lilly is also pairing it with tirzepatide as EloraTZP.
Calculate with EloralintideDosage chart

Quick facts

Half-life
  • About 13 to 15 days (310 to 366 hours) after single doses of 0.04 to 12 mg in healthy adults; levels peak 72 to 132 hours after a shot.
Routes
  • Subcutaneous injection
Forms
  • Vial (powder)
Reported dose ranges
  • 0.5 to 12 mg (subcutaneous injection)
Vial sizes
  • 10 mg, 30 mg
Chemistry
  • 4,526 g/mol · C201H319N49O65S2 · CAS 2883634-40-8
FDA status
  • In clinical trials
WADA
  • Not confirmed

What people use Eloralintide for

  • Weight loss on its own, the focus of Lilly's ENLIGHTEN phase 3 program
  • Weight and blood sugar in type 2 diabetes
  • Adding to tirzepatide (EloraTZP), Lilly's lead combination
  • An amylin add-on that Reddit users hope causes fewer side effects than cagrilintide

How it is thought to work. Eloralintide is a 37-amino-acid amylin analog with a C20 fatty-acid chain that binds albumin and stretches its half-life to about two weeks. In cell assays it was about 12 times more active at the human amylin 1 receptor than at the calcitonin receptor. Amylin signaling tells the brain a meal is ending and slows stomach emptying. It does not act on GLP-1 receptors. In rats it caused less taste avoidance, a nausea marker, than cagrilintide.

Eloralintide dosing

8 protocols from studies, guides and community reports, grouped by goal. Tap a source badge to see where a number came from.

Weight loss3

Weight loss, phase 2 fixed doses (clinical trial)

Amount
1 to 9 mg
How often
Once weekly at 1, 3, 6 or 9 mg depending on arm
Route
Subcutaneous injection
Cycle
48 weeks, continuous
Timing and details

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Weight loss, phase 2 slow escalation 3 to 9 mg (clinical trial)

Amount
3 to 9 mg
How often
Once weekly, 3 mg for 4 weeks, 6 mg for 4 weeks, then 9 mg
Route
Subcutaneous injection
Cycle
48 weeks
Titration (3 steps) and details

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Weight loss, phase 2 escalation 6 to 9 mg (clinical trial)

Amount
6 to 9 mg
How often
Once weekly, 6 mg for 20 weeks, then 9 mg
Route
Subcutaneous injection
Cycle
48 weeks
Titration (2 steps) and details

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Other protocols: injected5

Phase 1 multiple doses, no escalation (clinical trial)

Amount
1.2 to 12 mg
How often
Once weekly at 1.2, 3, 6 or 12 mg by cohort
Route
Subcutaneous injection
Cycle
12 weeks
Timing and details

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Type 2 diabetes, phase 2 (clinical trial)

Amount
1 to 9 mg
How often
Once weekly, starting at 1 or 3 mg and escalating to 6 or 9 mg
Route
Subcutaneous injection
Cycle
48 weeks
Timing and details

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With tirzepatide, EloraTZP phase 2 (clinical trial)

Amount
3 to 9 mg
How often
Once weekly eloralintide 3 to 9 mg plus weekly tirzepatide 5 to 15 mg
Route
Subcutaneous injection
Cycle
48 weeks
Timing and details

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Four-step ladder to 9 mg (dosing guide)

Amount
1 to 9 mg
How often
Once weekly, stepping 1, 3, 6, then 9 mg every 4 weeks
Route
SubQ, vial (powder)
Titration (4 steps) and details

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Low-dose range (dosing guide)

Amount
0.5 to 2 mg
How often
Once weekly at 0.5 to 2 mg
Route
SubQ, vial (powder)
Timing and details

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Doses shown are what sources report, labelled by origin. Not medical advice.

Full Eloralintide dosage guideEvery titration step in syringe units, missed doses and how to mix.

Vial strengths and syringe units

Every Eloralintide vial size with the water volumes sources use. Units are what to draw on a U-100 insulin syringe, worked out exactly.
Eloralintide: concentration and U-100 syringe units for each vial size and water volume
WaterStrength1 mgdose, units3 mgdose, units9 mgdose, units
10 mg vial
1 mLCompetitor guide10 mg/mL100.1 mL300.3 mL900.9 mL
2 mLCompetitor guide5 mg/mL200.2 mL600.6 mL1801.8 mL2 draws
30 mg vial
3 mLCompetitor guide10 mg/mL100.1 mL300.3 mL900.9 mL
Units are on a U-100 insulin syringe (100 units = 1 mL). U-50 and U-30 barrels read the same units.Water volumes from

Doses shown are what sources report, labelled by origin. Not medical advice.

Calculate with this peptideYour vial, your water, your dose: Eloralintide in syringe units, with the math shown.

Eloralintide side effects

What trials and labels report, kept apart from what users and guides report. Frequencies are worded as each source states them.

Reported in studies and labels6

From clinical trials and regulatory documents.

  • Nausea

    11% (1 mg), 13% (3 mg), 64% (6 mg), 33% (9 mg), 54% (6 to 9 mg), 25% (3 to 9 mg) vs 14% on placebo over 48 weeks

    How people manage it

    • In the trial, the slow 3 to 6 to 9 mg climb had far less nausea than starting at 6 mg.

  • Fatigue

    0% (1 mg), 13% (3 mg), 29% (6 mg), 43% (9 mg), 46% (6 to 9 mg), 21% (3 to 9 mg) vs 12% on placebo

  • Vomiting

    7 of 28 people at 6 mg and 6 of 54 at 9 mg vs none of 53 on placebo; 1 of 52 in the slow 3 to 9 mg arm

  • Constipation

    13 of 54 people at 9 mg vs 3 of 53 on placebo; 2 to 4 people in the other arms

  • Hair loss

    6 of 54 people at 9 mg and 5 of 52 in the 3 to 9 mg arm vs none on placebo

  • Slower heart rate

    Bradycardia in 3 people each in the 6 mg, 9 mg and 3 to 9 mg arms vs none on placebo; pulse fell during treatment in phase 1

All 9 Eloralintide side effects and how people manage themEvery management tip, who should not use it, and side-effect questions.

Storage

Powder (before mixing)

Temperature
-20 °C

Freezer at -20 °C.

Mixed vial

Temperature
2 to 8 °C

Fridge at 2 to 8 °C, protected from light. The seller gives no use-within period.

Mixed vial

Temperature
2 to 8 °C

Fridge at 2 to 8 °C and use within about 4 weeks per one guide; another says no discard period has been established. Do not shake, avoid freeze-thaw.

Mixed with: Bacteriostatic water

Mixing. Trial publications do not describe mixing research powder. PeptideDosages calls its 1 mL preparation a worked calculation, not a trial formulation. Trial doses run to 9 mg, so a 10 mg vial holds about one high dose; plan water for an easy draw.

Stacks people report

Combinations from guides and community posts, with the reason given.
  • Tirzepatide

    Lilly's own combination (EloraTZP). In type 2 diabetes, eloralintide 9 mg plus tirzepatide 15 mg gave 23.3% weight loss at 48 weeks vs 14.8% on tirzepatide alone, with more people stopping for side effects. A co-formulation goes into phase 3.

  • Retatrutide

    Some retatrutide users on Reddit plan to add eloralintide for appetite control after seeing the trial data. No trial has tested the pair.

Compare Eloralintide

Evidence and legal status

Evidence: some human trials

Two phase 1 studies, a 263-person 48-week phase 2 in obesity, and a 367-person phase 2 in type 2 diabetes (press release so far). ClinicalTrials.gov lists five ENLIGHTEN phase 3 trials (ENLIGHTEN-1, 2, 3, 4 and 6), all still running with no results yet. No data exist on research vials.

FDA and WADA

In clinical trials

Under FDA-regulated trials; not approved yet.

Not FDA approved. Eloralintide is investigational: Lilly is running phase 3 trials (ENLIGHTEN-1 started February 2026, primary completion estimated March 2028). Drugs@FDA lists no product containing it as of 2026-10-24. Research-labeled vials are not Lilly's product.

Not named on FDA's list of bulk substances that may pose safety risks in compounding (current 04/22/2026). WADA's 2026 Prohibited List does not name eloralintide or amylin analogues; as an unapproved drug it may fall under the non-approved substances class (S0). Unconfirmed.

WADA: Not confirmed

Eloralintide questions

What is eloralintide?

A once-weekly amylin drug from Eli Lilly (code LY3841136). It mimics amylin, a fullness hormone, and favors the amylin 1 receptor over the calcitonin receptor. It is not a GLP-1 drug.

Is eloralintide FDA approved?

No. It is in phase 3 trials (ENLIGHTEN), and Drugs@FDA lists no product containing it as of October 24, 2026. ENLIGHTEN-1's primary completion is estimated for March 2028.

How much weight do people lose on eloralintide?

In the 48-week phase 2 trial, -9% at 1 mg, -12% at 3 mg, -18% at 6 mg and -20% at 9 mg, vs -0.4% on placebo. In people with type 2 diabetes, eloralintide alone reached -12.3% at 6 mg.

What eloralintide doses were tested?

Phase 2 used 1, 3, 6 and 9 mg once weekly, plus two escalation arms (3 to 6 to 9 mg in 4-week steps, and 6 mg for 20 weeks then 9 mg). Phase 1 went up to 12 mg weekly for 12 weeks. No dose is approved.

What are the side effects of eloralintide?

Nausea and fatigue lead, and both rise with dose: at 9 mg, 33% nausea and 43% fatigue vs 14% and 12% on placebo. The trial registry also lists vomiting, constipation, hair loss and slower heart rate in some people at higher doses.

Does starting low help with eloralintide nausea?

In phase 2, people who started at 6 mg had 64% nausea. People who climbed 3 to 6 to 9 mg had 25%, while still losing 16% of their weight.

Eloralintide vs cagrilintide: what is the difference?

Eloralintide favors the amylin 1 receptor; cagrilintide also hits the calcitonin receptor. Eloralintide's half-life is about 13 to 15 days vs about 7 to 8 for cagrilintide. In rats eloralintide caused less taste avoidance. No human head-to-head trial exists.

Eloralintide vs retatrutide: which loses more weight?

In separate phase 2 trials at 48 weeks, retatrutide 12 mg reached -24.2% and eloralintide 9 mg -20%. They work on different hormones and were never tested against each other.

What is EloraTZP?

Lilly's combination of eloralintide with tirzepatide. In a 48-week type 2 diabetes trial, eloralintide 9 mg plus tirzepatide 15 mg gave -23.3% vs -14.8% on tirzepatide 15 mg alone. Lilly plans phase 3 of a single-injection version by the end of 2026.

How long does eloralintide stay in the body?

Its half-life was 310 to 366 hours (about 13 to 15 days) across single doses in phase 1, with levels peaking 72 to 132 hours after a shot.

How much bacteriostatic water for a 10 mg eloralintide vial?

Dosing guides use 1 mL (10 mg/mL) or 2 mL (5 mg/mL). More water makes small doses easier to draw. The trials did not publish a mixing method for research powder.

How should eloralintide be stored?

Sellers list the powder at -20 °C. After mixing, keep it in the fridge at 2 to 8 °C and away from light. One dosing guide says use it within about 4 weeks; another says no discard period has been established for research vials.

Are research eloralintide vials reliable?

On r/Retatrutide, users report kits that tested with no eloralintide at all, or with a different drug such as semaglutide or cagrilintide. Lilly's product is only available in trials.

Ask about Eloralintide

Answers come from this site's pages only, with a link to each source.

Sources

23 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Clinical study10

  1. Billings et al. Eloralintide 48-week phase 2 trial (Lancet 2025)PubMed · checked Oct 24, 2026
  2. NCT06230523 phase 2 registry record with posted resultsClinicalTrials.gov · checked Oct 24, 2026
  3. Eloralintide phase 1 proof of concept, 12 weeks (Diabetes Obes Metab 2026)PubMed Central · checked Oct 24, 2026

Reference work1

  1. Eloralintide, CID 175663130PubChem · checked Oct 24, 2026

Vendor guide2

  1. Buy Eloralintide 10MGpspeptides.com · checked Oct 24, 2026
  2. Eloralintide (acetate), item 45770Cayman Chemical · checked Oct 24, 2026

Competitor guide3

  1. Eloralintide Dosage Chart, Schedule & Reconstitution Protocolpeptidedosage.org · checked Oct 24, 2026
  2. Eloralintide (10 mg Vial) Dosage Protocolpeptidedosages.com · checked Oct 24, 2026
  3. Eloralintide Dosing Calculatorpeptideprotocolwiki.com · checked Oct 24, 2026

Community-reported2

  1. Can someone stay at 2mg instead of going higher? (comment)r/Retatrutide · checked Oct 24, 2026
  2. Reta + Elora (comment)r/Retatrutide · checked Oct 24, 2026