Skip to content
Limited human dataNot FDA approved

LL-37 dosage

Also known as: LL37 · LL 37 · Cathelicidin · Human cathelicidin antimicrobial peptide · CAP-18 · hCAP-18 fragment · Ropocamptide

Updated 34 sources

Every LL-37 protocol on file, 18 in all, labelled by where each number came from. 3 have titration steps, each step is worked out in U-100 units for a 5 mg vial + 1 mL water.

Calculate with LL-37LL-37 overview

LL-37 dosage by goal

Grouped by goal. Each protocol shows the amount, how often, cycle and rest as the source states them, with every titration step.

Venous leg ulcer gel2

Venous leg ulcer gel (trial)

Amount
0.5 to 3.2 mg/mL
How often
Twice weekly, applied to the ulcer
Route
Topical, topical
Cycle
4 weeks of treatment

Who: 34 adults with hard-to-heal venous leg ulcers in the 2014 first-in-man trial.

Note: 0.5 mg/mL healed best (about six times the placebo healing rate); 3.2 mg/mL did no better than placebo.

Venous leg ulcer gel (Phase IIb)

Amount
0.5 to 1.6 mg/mL
How often
Twice weekly at dressing changes, with compression
Route
Topical, topical
Cycle
13 weeks

Who: 148 adults with hard-to-heal venous leg ulcers (HEAL LL-37).

Note: No significant healing benefit in the full study population; a post hoc look found benefit in ulcers of 10 cm2 or more.

Other protocols: injected14

Community daily structure

Amount
100 to 500 mcg
How often
Once daily, often 5 days on and 2 off
Route
SubQ, vial (powder)
Cycle
2 to 4 weeks, then a break of 2 weeks or more
Rest
2 weeks or more

Timing: Most write-ups start at 100 to 200 mcg; 500 mcg is the top of the range.

Note: No human trial has tested LL-37 by injection. These are community figures collected by guides. The community aggregator lists the same 100 to 200 mcg dose over 8 to 12 weeks rather than 2 to 4.

Weekly ladder

Amount
50 to 400 mcg
How often
Once daily, optionally 5 days on and 2 off
Route
SubQ, vial (powder)
Cycle
8 to 12 weeks, up to 16
Titration steps for Weekly ladder
WhenDoseU-100 units (5 mg vial + 1 mL water)
Week 150 mcg1 units · 0.01 mL
Week 2100 mcg2 units · 0.02 mL
Week 3150 mcg3 units · 0.03 mL
Week 4200 mcg4 units · 0.04 mL
Week 5250 mcg5 units · 0.05 mL
Week 6300 mcg6 units · 0.06 mL
Week 7350 mcg7 units · 0.07 mL
Week 8400 mcg8 units · 0.08 mL

Note: Adds about 50 mcg a week as tolerated, aiming for 200 to 400 mcg by weeks 4 to 8.

Immune support

Amount
100 to 200 mcg
How often
Once daily
Route
SubQ, vial (powder)
Cycle
4 to 8 weeks; one guide cycles 8 weeks on, 4 off
Rest
4 weeks off
Titration steps for Immune support
WhenDoseU-100 units (5 mg vial + 1 mL water)
Week 1100 mcg2 units · 0.02 mL
Weeks 2 to 8200 mcg4 units · 0.04 mL

Gut barrier

Amount
100 to 200 mcg
How often
Once daily
Route
SubQ, vial (powder)
Cycle
4 to 8 weeks

Note: Usually stacked with BPC-157 and KPV. Injected, not swallowed, even for gut goals.

Conservative start

Amount
25 to 50 mcg
How often
Daily
Route
SubQ, vial (powder)
Cycle
1 to 2 weeks, then reassess

Standard (every day or every other day)

Amount
100 mcg
How often
Daily or every other day
Route
SubQ, vial (powder)
Cycle
4 to 8 weeks

Timing: Morning in the guide's weekly chart.

Higher daily

Amount
200 mcg
How often
Daily
Route
SubQ, vial (powder)
Cycle
4 to 6 weeks at most

Tolerance test dose

Amount
100 mcg
How often
Once, then wait 48 to 72 hours
Route
SubQ, vial (powder)

Timing: Watch for a big site reaction, flu-like symptoms or a psoriasis or rosacea flare before continuing.

Chronic infection, 3 times a week

Amount
200 to 500 mcg
How often
3 times a week (Mon, Wed, Fri), dropping to twice weekly in the taper
Route
SubQ, vial (powder)
Cycle
8 weeks
Rest
4 weeks off
Titration steps for Chronic infection, 3 times a week
WhenDoseU-100 units (5 mg vial + 1 mL water)
Week 1200 mcg4 units · 0.04 mL
Weeks 2 to 6500 mcg10 units · 0.1 mL
Weeks 7 to 8250 mcg5 units · 0.05 mL

Short daily course

Amount
250 to 500 mcg
How often
Daily
Route
SubQ, vial (powder)
Cycle
2 to 4 weeks

Note: The guide pairs it with conventional antimicrobials from a clinician.

Extended induction then maintenance

Amount
500 mcg
How often
Daily for 4 to 6 weeks, then 3 times a week for 8 to 16 weeks
Route
SubQ, vial (powder)
Cycle
12 to 22 weeks in total
Rest
4 to 8 weeks

Note: The same guide says continuous daily use beyond 16 weeks is uncharacterized.

Pulse course

Amount
500 to 750 mcg
How often
Daily
Route
SubQ, vial (powder)
Cycle
2 to 4 weeks, then a long break

Note: Top of the range. The guide says doses above 1 mg per injection are not supported.

Acute infection (community)

Amount
200 to 400 mcg
How often
Once daily
Route
SubQ, vial (powder)
Cycle
2 to 4 weeks

Note: Some users report flu-like symptoms at these doses.

Anecdotal low daily

Amount
125 mcg
How often
Daily
Route
SubQ, vial (powder)

Other protocols: topical, topical1

Topical solution on a wound

Amount
0.01 to 0.05 mg/mL
How often
Once or twice daily until the wound closes
Route
Topical, topical

Note: Stated as 10 to 50 mcg/mL. Not for rosacea or psoriatic skin.

Other protocols: other route1

Intratumoral injection (trial)

Amount
250 mcg
How often
Once weekly into each injected tumour
Route
Other route
Cycle
Up to 8 weeks

Who: Melanoma patients with skin metastases in a small Phase 1/2 dose-escalation study (4 enrolled).

Note: Starting dose per tumour, injected into 2 to 4 tumours. A cancer trial, not a wellness protocol.

Doses shown are what sources report, labelled by origin. Not medical advice.

LL-37 dosage chart by vial size

Units to draw for the doses sources cite most, at every vial size and water volume.
LL-37: concentration and U-100 syringe units for each vial size and water volume
WaterStrength100 mcgdose, units200 mcgdose, units500 mcgdose, units
5 mg vial
1 mLCompetitor guide5 mg/mL20.02 mL40.04 mL100.1 mL
2 mLCompetitor guide2.5 mg/mL40.04 mL80.08 mL200.2 mL
3 mLCompetitor guide1.667 mg/mL60.06 mL120.12 mL300.3 mL
10 mg vial
2 mLCompetitor guide5 mg/mL20.02 mL40.04 mL100.1 mL
Units are on a U-100 insulin syringe (100 units = 1 mL). U-50 and U-30 barrels read the same units.Water volumes from

Doses shown are what sources report, labelled by origin. Not medical advice.

Calculate with this peptideYour vial, your water, your dose: LL-37 in syringe units, with the math shown.

Mixing LL-37

Diluent: Bacteriostatic water

Water volumes sources use: 1 mL, 2 mL, 3 mL

Doses are small, so a 30 or 50 unit syringe reads more easily. The solution should be clear and colourless; discard it if cloudy.

LL-37 dosage questions

What dose do people use?

Community write-ups cluster at 100 to 250 mcg subQ once daily, often 5 days on and 2 off, for 2 to 4 weeks. Guides start at 25 to 100 mcg and some go to 500 or 750 mcg. No injection dose has been tested in people.

How many units is 250 mcg?

With 5 mg in 2 mL of water, 250 mcg is 10 units on a U-100 syringe. With 5 mg in 1 mL it is 5 units. Use the calculator for other mixes.

How long should a cycle be?

Short blocks of 2 to 4 weeks with 2 or more weeks off are the most common. Some guides run 8 to 12 weeks, rarely 16. No cycle length has been validated.

How long does mixed LL-37 last?

Keep it at 2 to 8 C. Advice runs from 7 days to 30 days, and forum users usually finish a vial in 2 to 3 weeks. It breaks down in solution, so mix only what you will use.

Sources for these doses

15 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Vendor guide4

  1. LL-37 5 mg product pageVendor product page · checked Oct 24, 2026
  2. LL-37 5 mg product pageVendor product page · checked Oct 24, 2026
  3. LL-37 5 mg product pageVendor product page · checked Oct 24, 2026
  4. LL-37 10 mg product pageVendor product page · checked Oct 24, 2026

Competitor guide4

  1. LL-37 (5 mg vial) dosage protocolpeptidedosages.com · checked Oct 24, 2026
  2. LL-37 profilepeptidesexplorer.com · checked Oct 24, 2026
  3. LL-37 protocol guidepathtopeptides.com · checked Oct 24, 2026
  4. LL-37 dosage guidebodyhackguide.co · checked Oct 24, 2026

Community-reported3

  1. LL-37 peptide protocol guide (community subQ structure)peptidedosingprotocols.com, via a competitor guide · checked Oct 24, 2026
  2. LL-37 community protocols and reportspeptideprotocolwiki.com, via a competitor guide · checked Oct 24, 2026
  3. LL-37 dosage calculator and chart (anecdotal dose)peptides.org, via a competitor guide · checked Oct 24, 2026

Back to the full LL-37 page for side effects, storage, stacks and legal status.