Also known as: MT-2 · MT2 · MT-II · Melanotan 2 · MT 2
Updated 49 sources
Every Melanotan II protocol on file, 12 in all, labelled by where each number came from. 2 have titration steps, each step is worked out in U-100 units for a 10 mg vial + 1 mL water.
Who: Three healthy men in the 1996 University of Arizona pilot phase I trial.
Note: Started at 0.01 mg/kg and stepped up by 0.005 mg/kg. Tanning showed after 5 doses. The authors recommended 0.025 mg/kg a day for later studies; 0.03 mg/kg caused grade II drowsiness and fatigue in one of two men.
Who: Adults using research vials. The guide frames this as research planning built from early trials and community use.
Timing: At bedtime, so peak nausea happens during sleep. Brief UV exposure is often coordinated.
Note: Step up only if nausea and flushing stay manageable. Fair skin (Fitzpatrick I to II) tends to respond at lower doses; darker skin may need a longer load.
Who: Adults who finished a loading phase.
Note: Light maintenance fits people with strong pigment and regular UV. Many pause in winter and reload before the next sunny stretch.
Who: Adults using research vials; very fair (type I) skin starts at 0.1 mg.
Timing: Evening, because nausea and flushing peak 30 to 90 minutes after the shot.
| When | Dose | U-100 units (10 mg vial + 1 mL water) |
|---|---|---|
| Days 1 to 3 | 0.25 mg | 2.5 units · 0.025 mL |
| Days 4 to 21 | 0.5 mg | 5 units · 0.05 mL |
Note: Move to maintenance once the wanted colour arrives: around days 7 to 14 for type III skin, 2 to 4 weeks for type I to II. The guide's cumulative-dose figures by skin type are not sourced.
Who: Adults after loading. Fair skin needs more frequent doses than olive or dark skin.
Note: A single 1 mg weekly dose may bring stronger side effects on the day.
Who: Adults using a 10 mg vial mixed with 3 mL (3.33 mg/mL).
| When | Dose | U-100 units (10 mg vial + 1 mL water) |
|---|---|---|
| Week 1 | 250 mcg | 2.5 units · 0.025 mL |
| Week 2 | 500 mcg | 5 units · 0.05 mL |
| Week 3 | 750 mcg | 7.5 units · 0.075 mL |
| Weeks 4 to 8 | 1,000 mcg | 10 units · 0.1 mL |
Note: The same guide says never exceed 2 mg a day. This ladder runs higher than most community practice.
Who: Self-reports on r/Melanotan2, 2025 to 2026.
Note: 250 mcg is called a beginner dose, then 500 mcg. Some load at 500 mcg to 1 mg and accept stronger nausea to tan faster. In one app's logs (46 reports) the most common dose per injection was 0.2 to 0.4 mg, with reports from 0.01 to 2 mg.
Who: Long-time and side-effect-sensitive users on r/Melanotan2.
Note: Some long-term users skip loading and say UV matters more than dose. One user stepped 100, 150, then 200 mcg a week at a time to dodge nausea.
Who: Self-reports on r/Melanotan2 after reaching a base tan.
Timing: Often about 30 minutes before sun or a sunbed, or just before.
Note: Reports range from 0.5 mg once a week to 50 to 100 mcg about every two weeks.
Who: Users avoiding needles. One guide and a few self-reports.
Note: The guide says nasal delivery loses 60 to 70% of the peptide and results take 10 to 21 days longer. One user sprayed 1 mg daily for 10 days with little effect, then tanned within a week by injection.
Who: Men with psychogenic or organic erectile dysfunction in two small placebo-controlled crossover trials of 10 men each (20 combined, pooled in a 2000 review).
Note: Erections followed in 17 of 20 men without sexual stimulation. Severe nausea hit 12.9% of subjects at this dose. A research dose, not a treatment plan.
Who: Users after the sexual effect, reported on a competitor guide.
Note: Lower than the 0.025 mg/kg used in ED trials, chosen for less nausea. PT-141 is the approved melanocortin drug for low desire in women.
Doses shown are what sources report, labelled by origin. Not medical advice.
| Water | Strength | 200 mcgdose, units | 0.5 mgdose, units | 1,000 mcgdose, units |
|---|---|---|---|---|
| 10 mg vial | ||||
| 1 mLCompetitor guide | 10 mg/mL | 20.02 mL | 50.05 mL | 100.1 mL |
| 2 mLCompetitor guide | 5 mg/mL | 40.04 mL | 100.1 mL | 200.2 mL |
| 3 mLCompetitor guide | 3.333 mg/mL | 60.06 mL | 150.15 mL | 300.3 mL |
| 5 mLCompetitor guide | 2 mg/mL | 100.1 mL | 250.25 mL | 500.5 mL |
Doses shown are what sources report, labelled by origin. Not medical advice.
Calculate with this peptideYour vial, your water, your dose: Melanotan II in syringe units, with the math shown.Diluent: Bacteriostatic water
Water volumes sources use: 1 mL, 2 mL, 3 mL, 5 mL
2 mL in a 10 mg vial is the common mix: 5 mg/mL, so 250 mcg is 5 units and 500 mcg is 10 units. Small doses read more easily on 0.3 mL (30-unit) syringes, users say. Run the water down the vial wall and swirl, do not shake.
Skip it and return to the normal schedule; pigment builds slowly, so one missed dose changes little. Do not double up.
Guides start at 100 to 250 mcg a day for the first 3 days to test nausea and flushing, and as low as 0.1 mg for very fair skin. On r/Melanotan2, 250 mcg is called a beginner dose before moving to 500 mcg; cautious users start at 50 to 150 mcg.
With a 10 mg vial mixed with 2 mL of bacteriostatic water (5 mg/mL), 250 mcg is 5 units and 500 mcg is 10 units on a U-100 insulin syringe. With 1 mL it is 2.5 and 5 units; with 3 mL it is 7.5 and 15 units. Use the calculator for your own mix.
Guides say skip it and carry on with the normal schedule. Pigment builds slowly, so one missed dose changes little. Do not double up.
22 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.
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