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Strong human trialsFDA approved as Vyleesi

PT-141 dosage

Also known as: Bremelanotide · Vyleesi · PT141

Updated 29 sources

Every PT-141 protocol on file, 9 in all, labelled by where each number came from.

Calculate with PT-141PT-141 overview

PT-141 dosage by goal

Grouped by goal. Each protocol shows the amount, how often, cycle and rest as the source states them, with every titration step.

Erections in men2

Erections in men, subQ phase 1/2 trial

Amount
0.3 to 10 mg
How often
Single doses; no repeat schedule tested
Route
Subcutaneous injection

Who: Healthy men and men with erectile dysfunction who did not respond to Viagra.

Note: Doses above 1.0 mg gave a significant erectile response. Men with ED got 4 or 6 mg. Never taken to approval for men.

Erections in men, intranasal trials

Amount
7.5 to 20 mg
How often
Single doses; no repeat schedule tested
Route
Nasal, nasal spray

Who: Healthy men and men with erectile dysfunction.

Timing: First erections came at around 30 minutes.

Note: Only doses above 7 mg produced significant erections. Trial arms were 7.5, 15 and 20 mg. 7.5 mg nasal plus 25 mg sildenafil beat sildenafil alone in a 19-man crossover. Nasal per-spray amounts on the market vary by device.

Other protocols: injected (prefilled pen)1

Low sexual desire in women, Vyleesi label dose

Amount
1.75 mg
How often
As needed. No more than 1 dose in 24 hours; more than 8 doses a month is not recommended.
Route
SubQ, prefilled pen

Who: Premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Not for men or postmenopausal women.

Timing: At least 45 minutes before sexual activity. Inject into the abdomen or thigh.

Note: Stop after 8 weeks if desire has not improved. In the phase 3 RECONNECT trials people used a median of 10 doses over 24 weeks, most 2 to 3 times a month and no more than once a week; the trial cap was 12 a month.

Other protocols: injected5

Women, label dose from a vial (guides)

Amount
1.75 mg
How often
As needed. No more than 1 dose in 24 hours; more than 8 doses a month is not recommended.
Route
SubQ, vial (powder)

Who: Women using research vials. Every guide we checked repeats the Vyleesi label dose.

Timing: At least 45 minutes before sexual activity.

Men, on-demand dose (guides)

Amount
1 to 2 mg
How often
As needed, not daily. Work up to 2 mg only after trying 1 to 1.75 mg first.
Route
SubQ, vial (powder)

Who: Men. No dose is approved for men; guides extrapolate from the label and early trials.

Timing: 1 to 2 hours before sexual activity.

Note: One guide starts at 1 mg. Another notes a study where 1.25 mg still worked, as a lower option if side effects bite.

First dose or tolerance test (guides)

Amount
0.5 to 1 mg
How often
Once, then wait to judge nausea before a full dose
Route
SubQ, vial (powder)

Who: First-time users checking how they handle nausea.

Note: One guide uses 1 mg as a test dose; another mentions 0.5 mg as a starting point for vial users.

Men and couples, community use

Amount
1 to 3 mg
How often
On demand. Some users cap it at twice a week.
Route
SubQ, vial (powder)

Who: Self-reports on r/Peptides and in one site's dose logs, mostly men, often already on TRT or a PDE5 inhibitor, plus couples using it for planned nights.

Timing: Onset of a couple of hours at most, per one r/Peptides user.

Note: Logged doses cluster at 2 to 3 mg, with a range of 0.1 mg to over 5 mg. About 2 mg is called the usual dose; some drop to 1 mg because it still works. Start very low is the standard advice after bad first experiences.

Daily step-up protocol (guide outlier)

Amount
500 to 1,500 mcg
How often
Once daily: 500 mcg for 8 weeks, then 1,000 mcg, then 1,500 mcg
Route
SubQ, vial (powder)
Cycle
16 weeks

Note: Unsourced, and it clashes with the label's 8-a-month limit. Label data shows dark skin patches in 38% after 8 daily doses in a row, versus 1% at label use.

Other protocols: nasal, nasal spray1

Men who failed sildenafil, intranasal trial

Amount
10 mg
How often
Single dose before sex
Route
Nasal, nasal spray

Who: Men with erectile dysfunction who did not respond to sildenafil.

Timing: 45 minutes to 2 hours before sex.

Note: 33.5% responded vs 8.5% on placebo. The paper now carries a 2023 expression of concern, so weigh it lightly.

Doses shown are what sources report, labelled by origin. Not medical advice.

Community-reported amounts

The PT-141 amounts people mention most on Reddit, by goal. Counts, not recommendations.
PT-141 amounts reported on Reddit, by goal, with mention counts
GoalMost reported amounts (mentions)
Sexual health1 mg (37), 0.5 mg (24), 1.5 mg (14), 2 mg (13)
Goal not stated0.5 mg (7), 1 mg (4), 1.5 mg (3), 10 mg (3)
From 555 Reddit posts and comments, last mined Oct 23, 2026.

PT-141 dosage chart by vial size

Units to draw for the doses sources cite most, at every vial size and water volume.
PT-141: concentration and U-100 syringe units for each vial size and water volume
WaterStrength0.5 mgdose, units1 mgdose, units1.75 mgdose, units
10 mg vial
1 mLCompetitor guide10 mg/mL50.05 mL100.1 mL17.50.175 mL
2 mLCompetitor guide5 mg/mL100.1 mL200.2 mL350.35 mL
2.5 mLCompetitor guide4 mg/mL12.50.125 mL250.25 mL43.80.438 mL
3 mLCompetitor guide3.333 mg/mL150.15 mL300.3 mL52.50.525 mL
Units are on a U-100 insulin syringe (100 units = 1 mL). U-50 and U-30 barrels read the same units.Water volumes from

Doses shown are what sources report, labelled by origin. Not medical advice.

Calculate with this peptideYour vial, your water, your dose: PT-141 in syringe units, with the math shown.

Mixing PT-141

Water volumes sources use: 1 mL, 2 mL, 2.5 mL, 3 mL

2 mL in a 10 mg vial is the most common mix, giving 5 mg per mL, so the 1.75 mg label dose is 0.35 mL. That is more than a 0.3 mL syringe holds, so use a 0.5 or 1 mL syringe. The Vyleesi pen is premixed and needs no water.

PT-141 dosage questions

What is the PT-141 dose for women?

The FDA label dose is 1.75 mg injected under the skin of the belly or thigh, at least 45 minutes before sex. That is the Vyleesi autoinjector. Guides for research vials repeat the same 1.75 mg.

What is the PT-141 dose for men?

No dose is approved for men. Guides say start at 1 mg and go up to 2 mg if needed. Community dose logs cluster at 2 to 3 mg. Early trials found erections improved above 1 mg subQ, and gave men with ED 4 or 6 mg.

How often can I take PT-141?

The label allows no more than 1 dose in 24 hours and does not recommend more than 8 doses a month. In the phase 3 trials most people used it 2 to 3 times a month.

How much water do I add to a 10 mg PT-141 vial?

2 mL is the common choice, giving 5 mg per mL, so 1.75 mg is 0.35 mL. Guides also use 1, 2.5 or 3 mL. Use the calculator for your exact vial and dose.

Sources for these doses

18 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory2

  1. Vyleesi (bremelanotide) prescribing information, 2019FDA · checked Oct 23, 2026
  2. Vyleesi label (current)DailyMed · checked Oct 23, 2026

Competitor guide6

  1. PT-141peptiq.io · checked Oct 23, 2026
  2. PT-141peptidedeck.com · checked Oct 23, 2026
  3. PT-141peptidesexplorer.com · checked Oct 23, 2026
  4. PT-141peptides.org · checked Oct 23, 2026

Community-reported6

  1. Comment: about 2 mg doser/Peptides · checked Oct 23, 2026
  2. Comment: 1.0 mg instead of 1.75 mg; oxytocinr/Peptides · checked Oct 23, 2026
  3. Comment: TRT and Cialis user on onset, side effects and a twice-weekly capr/Peptides · checked Oct 23, 2026
  4. Comment: headache and nausea, start lowr/Peptides · checked Oct 23, 2026

Back to the full PT-141 page for side effects, storage, stacks and legal status.