Strong human trialsFDA approved as Ozempic +2

Semaglutide dosage

Also known as: Ozempic · Wegovy · Wegovy HD · Rybelsus · Ozempic tablets · Compounded semaglutide

Updated Oct 23, 202632 sources

Every Semaglutide protocol on file, 12 in all, labelled by where each number came from. 3 have titration steps, each step is worked out in U-100 units for a 5 mg vial + 2 mL water.

Calculate with Semaglutide Semaglutide overview

Semaglutide dosage by goal

Grouped by goal. Each protocol shows the amount, how often, cycle and rest as the source states them, with every titration step.

Type 2 diabetes3

Type 2 diabetes, FDA label titration (Ozempic injection)

Amount: 0.25 to 2 mg
How often: Once weekly, same day each week; at least 4 weeks per step, then hold at 0.5, 1 or 2 mg (2 mg max)
Route: Subcutaneous injection
Cycle: Long term; the label has no off cycle

Who: Adults with type 2 diabetes, per the Ozempic label. 0.25 mg is a starter step, not a treatment dose. Step up only when more blood sugar control is needed.

Timing: Inject under the skin of the belly, thigh or upper arm. A missed dose can be taken within 5 days.

Titration steps for Type 2 diabetes, FDA label titration (Ozempic injection)
When	Dose	U-100 units (5 mg vial + 2 mL water)
Weeks 1 to 4	0.25 mg	10 units · 0.1 mL
Weeks 5 to 8	0.5 mg	20 units · 0.2 mL
Weeks 9 to 12	1 mg	40 units · 0.4 mL
Weeks 13 to 16	2 mg	80 units · 0.8 mL

Type 2 diabetes, FDA label titration (Rybelsus tablets, oral)

Amount: 3 to 14 mg
How often: Once daily; 30 days at 3 mg, then 7 mg, then 14 mg if needed; hold at 7 or 14 mg
Route: Oral

Who: Adults with type 2 diabetes on Rybelsus. Rybelsus and Ozempic tablets are not swappable mg for mg.

Timing: On an empty stomach with up to 4 oz of water, then wait 30 minutes before eating.

Type 2 diabetes, FDA label titration (Ozempic tablets, oral)

Amount: 1.5 to 9 mg
How often: Once daily; 30 days at 1.5 mg, then 4 mg, then 9 mg if needed; hold at 4 or 9 mg
Route: Oral

Who: Adults with type 2 diabetes. Added to the label in August 2026. Not swappable mg for mg with Rybelsus.

Timing: On an empty stomach with up to 4 oz of water, then wait 30 minutes before eating.

Weight loss6

Weight loss, FDA label titration (Wegovy injection)

Amount: 0.25 to 2.4 mg
How often: Once weekly; 4 weeks per step, then hold at 2.4 mg
Route: Subcutaneous injection
Cycle: Long term; the label has no off cycle

Who: Adults on branded Wegovy for weight, heart risk or MASH, per the label. 1.7 mg is an allowed maintenance dose if 2.4 mg is not tolerated.

Timing: Same day each week. Stomach side effects cluster around each step up.

Titration steps for Weight loss, FDA label titration (Wegovy injection)
When	Dose	U-100 units (5 mg vial + 2 mL water)
Weeks 1 to 4	0.25 mg	10 units · 0.1 mL
Weeks 5 to 8	0.5 mg	20 units · 0.2 mL
Weeks 9 to 12	1 mg	40 units · 0.4 mL
Weeks 13 to 16	1.7 mg	68 units · 0.68 mL
Weeks 17 to 20	2.4 mg	96 units · 0.96 mL

Weight loss, FDA label high dose (Wegovy HD 7.2 mg)

Amount: 7.2 mg
How often: Once weekly at 7.2 mg (label maximum)
Route: Subcutaneous injection

Who: Adults who have tolerated Wegovy 2.4 mg for at least 4 weeks. Approved 2026-03-19. In STEP UP, 7.2 mg averaged 18.8% weight loss at 72 weeks vs 15.5% on 2.4 mg.

Weight loss, FDA label titration (Wegovy tablets, oral)

Amount: 1.5 to 25 mg
How often: Once daily; 30 days each at 1.5, 4 and 9 mg, then hold at 25 mg
Route: Oral

Who: Adults on branded oral Wegovy. Approved December 2025. In OASIS 4, 25 mg averaged 13.6% weight loss at 64 weeks vs 2.4% on placebo.

Timing: On an empty stomach with up to 4 oz of water, then wait 30 minutes before eating.

Weight loss, compounded or research vial, Wegovy-style ladder (guide protocol)

Amount: 0.25 to 2.4 mg
How often: Once weekly; 4 weeks per step, then hold at 2.4 mg
Route: Subcutaneous injection

Who: People using compounded or research-labeled vials, following guides that copy the Wegovy steps. These vials have no trial data or verified identity.

Timing: If side effects hit after a step up, guides say stay on the current dose for another 4 weeks before moving up. Check your vial's concentration before reading any units chart.

Titration steps for Weight loss, compounded or research vial, Wegovy-style ladder (guide protocol)
When	Dose	U-100 units (5 mg vial + 2 mL water)
Weeks 1 to 4	0.25 mg	10 units · 0.1 mL
Weeks 5 to 8	0.5 mg	20 units · 0.2 mL
Weeks 9 to 12	1 mg	40 units · 0.4 mL
Weeks 13 to 16	1.7 mg	68 units · 0.68 mL
Weeks 17 to 20	2.4 mg	96 units · 0.96 mL

Weight loss, 10 mg research vial start and maintenance (guide protocol)

Amount: 300 to 1,000 mcg
How often: Once weekly; start at 300 mcg, maintenance at 1,000 mcg
Route: Subcutaneous injection

Who: People mixing a 10 mg research vial with 1.5 mL of bacteriostatic water, per one guide. No trial tested this.

Weight loss, common community compounded range

Amount: 0.25 to 2.5 mg
How often: Once weekly, ongoing
Route: Subcutaneous injection

Who: Self-reported in community posts gathered from r/Semaglutide, r/Ozempic and r/Peptides. No trial tested compounded vials.

Timing: Many step up every 6 to 8 weeks for a slow climb. Faster steps of 2 to 3 weeks are reported but less common. Smaller meals and slower steps are the usual answer to nausea.

Other protocols: injected3

Weight loss with cagrilintide, REDEFINE 1 trial dose (CagriSema)

Amount: 0.25 to 2.4 mg
How often: Once weekly, starting at 0.25 mg and stepping up every 4 weeks to 2.4 mg
Route: Subcutaneous injection
Cycle: 68 weeks in REDEFINE 1

Who: Adults in REDEFINE 1, on semaglutide plus cagrilintide at 2.4 mg each. CagriSema is not approved; DIY versions use research vials with no trial data.

Maintenance after goal weight, sub-max dose (community)

Amount: 0.5 to 1.7 mg
How often: Once weekly at a dose below the top step
Route: Subcutaneous injection

Who: Self-reported in community posts. 1 to 1.7 mg is the commonly cited maintenance dose and 0.5 to 1 mg the low end. No trial tested reduced maintenance doses.

Timing: Some maintenance guides keep the same dose but stretch the gap to every 10, 12 or 14 days.

Microdosing, split low dose (community)

Amount: 0.125 to 0.25 mg
How often: Twice weekly
Route: Subcutaneous injection

Who: Self-reported in community posts. No trial tested microdosing. In one survey of 8,486 injectable GLP-1 users, 15% said they microdose, mostly for side effects, cost or maintenance.

Timing: Maintenance guides define microdosing as less than 0.25 mg a week, so definitions vary.

Doses shown are what sources report, labelled by origin. Not medical advice.

Community-reported amounts

The Semaglutide amounts people mention most on Reddit, by goal. Counts, not recommendations.

Semaglutide amounts reported on Reddit, by goal, with mention counts
Goal	Most reported amounts (mentions)
Weight loss	1 mg (127), 0.25 mg (93), 0.5 mg (80), 1.5 mg (38)
Goal not stated	1 mg (18), 0.25 mg (17), 0.5 mg (5), 2 mg (4)
Metabolic health	0.25 mg (4), 0.5 mg (2)

From 900 Reddit posts and comments, last mined Oct 24, 2026.

Semaglutide dosage chart by vial size

Units to draw for the doses sources cite most, at every vial size and water volume.

Semaglutide: concentration and U-100 syringe units for each vial size and water volume
Water	Strength	0.25 mgdose, units	2 mgdose, units	2.4 mgdose, units
5 mg vial
2 mLCompetitor guide	2.5 mg/mL	100.1 mL	800.8 mL	960.96 mL
10 mg vial
1.5 mLCompetitor guide	6.667 mg/mL	3.80.038 mL	300.3 mL	360.36 mL
2 mLCompetitor guide	5 mg/mL	50.05 mL	400.4 mL	480.48 mL
3 mLCompetitor guide	3.333 mg/mL	7.50.075 mL	600.6 mL	720.72 mL
4 mLCompetitor guide	2.5 mg/mL	100.1 mL	800.8 mL	960.96 mL
20 mg vial
1.5 mLCompetitor guide^†	13.333 mg/mL	1.90.019 mL	150.15 mL	180.18 mL
2 mLCompetitor guide^†	10 mg/mL	2.50.025 mL	200.2 mL	240.24 mL
3 mLCompetitor guide^†	6.667 mg/mL	3.80.038 mL	300.3 mL	360.36 mL
4 mLCompetitor guide^†	5 mg/mL	50.05 mL	400.4 mL	480.48 mL
30 mg vial
1.5 mLCompetitor guide^†	20 mg/mL	1.30.013 mL	100.1 mL	120.12 mL
2 mLCompetitor guide^†	15 mg/mL	1.70.017 mL	13.30.133 mL	160.16 mL
3 mLCompetitor guide^†	10 mg/mL	2.50.025 mL	200.2 mL	240.24 mL
4 mLCompetitor guide^†	7.5 mg/mL	3.30.033 mL	26.70.267 mL	320.32 mL

Units are on a U-100 insulin syringe (100 units = 1 mL). U-50 and U-30 barrels read the same units.† Water volume sourced for a different vial size. The math is exact either way.Water volumes from

Doses shown are what sources report, labelled by origin. Not medical advice.

Calculate with this peptideYour vial, your water, your dose: Semaglutide in syringe units, with the math shown.

Mixing Semaglutide

Diluent: Bacteriostatic water

Water volumes sources use: 1.5 mL, 2 mL, 3 mL, 4 mL

For a 5 mg vial, 2 mL is the most common answer. For 10 mg, guides split between 2 and 3 mL. Compounded pharmacy semaglutide usually arrives as a ready liquid from 2.5 to 12.5 mg per mL, with 5 mg per mL the most common; a pink tint usually means added B12. Every concentration changes what a syringe unit holds, so read units only against your own vial.

Semaglutide dosage questions

How much bacteriostatic water do I mix with a 5 mg vial of semaglutide?

2 mL is the most common answer in dosing guides. Whatever you pick, enter your exact vial size and water volume in a calculator before converting doses to syringe units.

How much bacteriostatic water for a 10 mg vial?

Guides disagree. 2, 3 and 4 mL all appear, with 2 and 3 mL the most common and one guide calling 3 mL the most recommended. Another guide uses 1.5 mL. More water means a weaker mix and more syringe units per dose.

What is the Wegovy dosing schedule?

0.25 mg weekly for 4 weeks, then 0.5, 1 and 1.7 mg for 4 weeks each, then 2.4 mg weekly as the maintenance dose. 1.7 mg is allowed if 2.4 mg is not tolerated. After at least 4 weeks on 2.4 mg, the label allows Wegovy HD at 7.2 mg.

What is the maximum Ozempic dose?

2 mg once a week. The label starts at 0.25 mg and moves up in steps of at least 4 weeks through 0.5 and 1 mg; 0.5, 1 and 2 mg are all maintenance doses.

Does the 7.2 mg Wegovy dose work better than 2.4 mg?

In STEP UP (72 weeks), 7.2 mg averaged 18.8% weight loss vs 15.5% on 2.4 mg and 3.9% on placebo. It also came with more odd skin sensations (22% vs 6%) and a bit more hair loss (5.8%).

Does semaglutide microdosing work?

No trial has tested it. Microdosing usually means less than 0.25 mg a week, and community posts describe 0.125 to 0.25 mg twice a week. In one survey of 8,486 injectable GLP-1 users, 15% said they microdose, mainly to limit side effects (40.8%), save money (31.9%) or maintain weight (29.6%).

How long does mixed semaglutide last?

About 28 days in the fridge, per dosing guides; one says 30. Do not freeze or shake it, and discard it if it turns cloudy or changes color.

Why do semaglutide units charts disagree?

Each chart is built for one concentration, and compounded and mixed vials range widely. The same number of units holds a very different dose from one vial to the next. FDA reports describe people drawing 5 to 20 times their intended dose this way. Work from your own vial's mg per mL every time.

Sources for these doses

15 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Clinical study2

REDEFINE 1 and REDEFINE 2 journal scanAmerican College of Cardiology · checked Oct 23, 2026
Cagrilintide and semaglutide trial protocol (NCT04982575)ClinicalTrials.gov · checked Oct 23, 2026

Regulatory5

Ozempic Prescribing Information (rev. 01/2025)FDA · checked Oct 23, 2026
Wegovy injection and tablets label (SPL v19, Jun 30 2026)DailyMed · checked Oct 23, 2026
FDA approves higher-dose WegovyBecker's Hospital Review · checked Oct 23, 2026
FDA approves Wegovy pill, the first oral GLP-1 to treat obesityHealio · checked Oct 23, 2026

Vendor guide3

GLP-1 Microdosing: Safety, Evidence, and MaintenancePerx Peptides · checked Oct 23, 2026
Research-labeled semaglutide listing (5 mg)Aura Peptide Co · checked Oct 23, 2026
Research-labeled semaglutide listing (10, 20, 30 mg)Orbitrex Peptides · checked Oct 23, 2026

Competitor guide4

Semaglutide 5 mg vial dosage protocolpeptidedosages.com · checked Oct 23, 2026
How much bacteriostatic water to mix with 10mg semaglutideSeekPeptides · checked Oct 23, 2026
Semaglutidepeptidesexplorer.com · checked Oct 23, 2026
Semaglutide 10 mg vial dosing protocolMyPeptideMatch · checked Oct 23, 2026

Community-reported1

Semaglutide: Community Protocols & ReportsPeptide Protocol Wiki · checked Oct 23, 2026

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