Semaglutide

2 mL is the most common answer in dosing guides. Whatever you pick, enter your exact vial size and water volume in a calculator before converting doses to syringe units.

Guides disagree. 2, 3 and 4 mL all appear, with 2 and 3 mL the most common and one guide calling 3 mL the most recommended. Another guide uses 1.5 mL. More water means a weaker mix and more syringe units per dose.

0.25 mg weekly for 4 weeks, then 0.5, 1 and 1.7 mg for 4 weeks each, then 2.4 mg weekly as the maintenance dose. 1.7 mg is allowed if 2.4 mg is not tolerated. After at least 4 weeks on 2.4 mg, the label allows Wegovy HD at 7.2 mg.

2 mg once a week. The label starts at 0.25 mg and moves up in steps of at least 4 weeks through 0.5 and 1 mg; 0.5, 1 and 2 mg are all maintenance doses.

In STEP UP (72 weeks), 7.2 mg averaged 18.8% weight loss vs 15.5% on 2.4 mg and 3.9% on placebo. It also came with more odd skin sensations (22% vs 6%) and a bit more hair loss (5.8%).

Its half-life is about a week, so it takes roughly 5 to 7 weeks after the last dose to clear.

Yes. Wegovy tablets go up to 25 mg daily for weight; in OASIS 4, 25 mg averaged 13.6% weight loss at 64 weeks vs 2.4% on placebo. Rybelsus (3, 7, 14 mg) and Ozempic tablets (1.5, 4, 9 mg) are for type 2 diabetes. All are taken on an empty stomach with a little water, 30 minutes before food. Rybelsus and Ozempic tablets are not swappable mg for mg.

FDA declared the shortage over on 2025-02-21. The grace periods for compounded copies ended on 2025-04-22 for 503A pharmacies and 2025-05-22 for 503B outsourcers. Enforcement kept going in 2026: 30 warning letters to telehealth firms in March, more in June, and a proposal to drop semaglutide from the 503B bulks list.

Tirzepatide won the only head-to-head trial. In SURMOUNT-5, it averaged 20.2% weight loss at 72 weeks vs 13.7% for semaglutide, a 6.5 point gap.

There is no validated dose conversion. Clinical guidance is to restart tirzepatide at a low dose and titrate up.

Dosing guides say no. Switch from one to the other; do not stack two of these drugs.

Most people regain a large share. In the STEP 1 extension, about two-thirds of the weight lost came back within a year of stopping. Label use is long term with no off cycle, which is why people look at maintenance doses.

Sometimes. On the Wegovy label, 3.3% of people on 2.4 mg reported hair loss vs 1% on placebo, more in women (4%) than men (0.9%). At 7.2 mg it was 5.8%.

No trial has tested it. Microdosing usually means less than 0.25 mg a week, and community posts describe 0.125 to 0.25 mg twice a week. In one survey of 8,486 injectable GLP-1 users, 15% said they microdose, mainly to limit side effects (40.8%), save money (31.9%) or maintain weight (29.6%).

About 28 days in the fridge, per dosing guides; one says 30. Do not freeze or shake it, and discard it if it turns cloudy or changes color.

Unused pens go in the fridge at 2 to 8°C. Once in use, an Ozempic pen lasts 56 days at 15 to 30°C or in the fridge. A Wegovy pen is single use and can sit at 8 to 30°C for up to 28 days before the cap comes off.

Each chart is built for one concentration, and compounded and mixed vials range widely. The same number of units holds a very different dose from one vial to the next. FDA reports describe people drawing 5 to 20 times their intended dose this way. Work from your own vial's mg per mL every time.