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Cagrilintide vs Retatrutide

Updated 10 sources

Key differences

  1. 1Retatrutide 12 mg reached 24.2% at 48 weeks in phase 2. Cagrilintide alone reached 10.8% at 4.5 mg over 26 weeks. These are separate trials; there is no head-to-head.
  2. 2Retatrutide hits GLP-1, GIP and glucagon receptors; cagrilintide hits amylin receptors, which is why people stack them.
  3. 3Cagrilintide is an amylin analogue. Retatrutide works through GLP-1, GIP and glucagon, with no amylin action.
  4. 4Cagrilintide is mostly used with semaglutide (CagriSema), which gave 20.4% loss at 68 weeks in REDEFINE 1.
  5. 5People stack the two because they hit different fullness pathways. That pair is untested.

Side by side

Facts from each record, in the same words as their own pages.
Cagrilintide and Retatrutide side by side
CagrilintideRetatrutide
Category
  • Weight loss
  • GLP-1, Weight loss
Evidence
  • Some human trials
  • Strong human trials
FDA status
  • In clinical trialsRegulatory
  • In clinical trialsRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • About 7 to 8 days (159 to 195 hours). Levels peak 1 to 3 days after a dose. Measured at 0.16 to 4.5 mg alongside semaglutide.Clinical study
  • About 6 days in the phase 1b trial, with exposure rising in proportion to dose. Built for once-weekly shots.Clinical study
Routes
  • Subcutaneous injection
  • Subcutaneous injection
Reported doses
  • 0.1 to 4.5 mg (subcutaneous injection)
  • 0.25 to 12 mg (subcutaneous injection)
Most cited frequency
  • Once weekly, added from week 9
  • Once weekly. Start at 2 mg, step up every 4 weeks to a target of 4, 9 or 12 mg, then hold.
Vial sizes
  • 5 mg, 10 mgCompetitor guide
  • 5 mg, 10 mg, 12 mg, 15 mg, 20 mg, 24 mg, 30 mg, 40 mg, 50 mg, 60 mgCompetitor guide
Mixed vial keeps
  • Keep the mixed vial at 2 to 8 °C, away from light, and use it within about 28 to 30 days.Community-reported
  • Keep the mixed vial in the fridge and use it within about 28 days.Community-reported
Protocols on file
  • 13
  • 18

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

10 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.