Cagrilintide vs CagriSema

Name: Cagrilintide vs CagriSema
Published: 2026-10-24

Updated Oct 24, 20266 sources

Key differences

1REDEFINE 1 at 68 weeks: 22.7% on CagriSema vs 11.8% on cagrilintide 2.4 mg alone if everyone adhered; 20.4% vs 11.5% counting everyone.
2More people stayed on the top dose of cagrilintide alone (82.5%) than of CagriSema (57.3%).

Facts from each record, in the same words as their own pages.

Cagrilintide and CagriSema side by side
	Cagrilintide	CagriSema
Category	Weight loss	Weight loss, GLP-1
Evidence	Some human trials	Strong human trials
FDA status	In clinical trialsRegulatory	In clinical trialsRegulatory
WADA	Not confirmed	Not confirmed
Half-life	About 7 to 8 days (159 to 195 hours). Levels peak 1 to 3 days after a dose. Measured at 0.16 to 4.5 mg alongside semaglutide.Clinical study	Cagrilintide component: 159 to 195 hours, peaking 24 to 72 hours after a dose (phase 1b, given with semaglutide).Clinical study Semaglutide component: 145 to 165 hours, peaking 12 to 24 hours after a dose (same trial).Clinical study
Routes	Subcutaneous injection	Subcutaneous injection
Forms	Not reported	Vial (powder)
Reported doses	0.1 to 4.5 mg (subcutaneous injection)	0.16 to 4.5 mg (subcutaneous injection)
Most cited frequency	Once weekly, added from week 9	Once weekly, cagrilintide and semaglutide at the same mg (2.4 mg + 2.4 mg at maintenance)
Vial sizes	5 mg, 10 mgCompetitor guide	5 mg, 10 mg, 20 mgVendor guide
Mixed vial keeps	Keep the mixed vial at 2 to 8 °C, away from light, and use it within about 28 to 30 days.Community-reported	Fridge at 2 to 8 °C, use within 30 days.Vendor guide
Protocols on file	13	6

Doses shown are what sources report, labelled by origin. Not medical advice.

6 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.