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Follistatin 344 vs IGF-1 LR3

Updated 13 sources

Key differences

  1. 1LR3 adds a growth signal at the IGF-1 receptor. Follistatin takes away a brake by binding myostatin.
  2. 2Forum doses: LR3 20 to 40 mcg a day for 4 to 6 weeks; follistatin 50 to 200 mcg a day for 10 to 30 days.
  3. 3Both are common partners in the same stack.

Side by side

Facts from each record, in the same words as their own pages.
Follistatin 344 and IGF-1 LR3 side by side
Follistatin 344IGF-1 LR3
Category
  • Other
  • GH axis
Evidence
  • Limited human data
  • Animal data only
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Prohibited
  • Prohibited
Half-life
  • Native FS315 had PK poorly suited to an injected drug in a Lilly study; an Fc-fused version had about 100-fold longer terminal half-life. No human figure.Clinical study
  • About 90 minutes for FS344, per one guide, with no source given.Competitor guide
  • 2 to 4 hours for recombinant protein, per another guide.Competitor guide
  • About 35 hours, per a third guide, with no source given.Competitor guide
  • Not measured in humans. In rats it cleared about 10 times faster than native IGF-1. The 20 to 30 hour figure quoted online has no human source.Competitor guide
Routes
  • Subcutaneous injection, Intramuscular injection
  • Subcutaneous injection, Intramuscular injection
Forms
  • Vial (powder)
Not reported
Reported doses
  • 50 to 500 mcg (subcutaneous injection)
  • 1 to 2.5 mcg/kg (subcutaneous injection)
  • 50 mcg (intramuscular injection)
  • 20 to 100 mcg (subcutaneous injection)
  • 10 to 20 mcg (intramuscular injection)
Most cited frequency
  • Once daily
  • Daily
Vial sizes
  • 1 mgCompetitor guide
  • 1 mgCompetitor guide
Mixed vial keeps
  • Fridge at 2 to 8 °C for 7 to 14 days; the guide suggests finishing within 7 days and freezing extra aliquots at -20 °C for up to 30 days.Competitor guide
  • Fridge, 2 to 8 °C.Competitor guide
Protocols on file
  • 12
  • 10

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

13 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory4

  1. 503A bulk drug substance categories (May 14, 2026)FDA · checked Oct 24, 2026
  2. Certain bulk drug substances, safety risksFDA · checked Oct 24, 2026
  3. openFDA Increlex applicationFDA · checked Oct 23, 2026
  4. Increlex labelDailyMed · checked Oct 23, 2026

Competitor guide4

  1. Follistatin 344 dosage guidePeptidesExplorer · checked Oct 24, 2026
  2. Follistatin dosing protocolsPeptide Protocol Wiki · checked Oct 24, 2026
  3. Follistatin 344PeptIQ · checked Oct 24, 2026
  4. IGF-1 LR3 dosage chartPeptideDeck · checked Oct 23, 2026

Community-reported2

  1. Performance-enhancing peptides modulating GH-IGF1 axis (Dominikowski 2026)PMC, via a study · checked Oct 24, 2026
  2. Follistatin community protocolsPeptide Protocol Wiki, via a competitor guide · checked Oct 24, 2026