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IGF-1 LR3 vs Ipamorelin

Updated 11 sources

Key differences

  1. 1Different targets. Ipamorelin raises your own GH through the pituitary; LR3 acts on the IGF-1 receptor directly.
  2. 2Ipamorelin is taken fasted; LR3 is taken with food or carbs.

Side by side

Facts from each record, in the same words as their own pages.
IGF-1 LR3 and Ipamorelin side by side
IGF-1 LR3Ipamorelin
Category
  • GH axis
  • GH axis
Evidence
  • Animal data only
  • Limited human data
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Prohibited
  • Prohibited
Half-life
  • Not measured in humans. In rats it cleared about 10 times faster than native IGF-1. The 20 to 30 hour figure quoted online has no human source.Competitor guide
  • About 2 hours after IV infusion in healthy men. Subcutaneous half-life has not been published.Clinical study
Routes
  • Subcutaneous injection, Intramuscular injection
  • Subcutaneous injection
Reported doses
  • 20 to 100 mcg (subcutaneous injection)
  • 10 to 20 mcg (intramuscular injection)
  • 100 to 400 mcg (subcutaneous injection)
Most cited frequency
  • Daily
  • Once daily, before bed
Vial sizes
  • 1 mgCompetitor guide
  • 2 mg, 5 mg, 10 mgCompetitor guide
Mixed vial keeps
  • Fridge, 2 to 8 °C.Competitor guide
  • Fridge, 2 to 8 °C.Competitor guide
Protocols on file
  • 10
  • 10

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

11 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory4

  1. openFDA Increlex applicationFDA · checked Oct 23, 2026
  2. Increlex labelDailyMed · checked Oct 23, 2026
  3. Certain bulk drug substances, safety risksFDA · checked Oct 23, 2026
  4. 503A bulk drug substance categories (May 14, 2026)FDA · checked Oct 23, 2026

Competitor guide3

  1. IGF-1 LR3 vs ipamorelinBodyHackGuide · checked Oct 23, 2026
  2. IGF-1 LR3 dosage guideBodyHackGuide · checked Oct 23, 2026
  3. IGF-1 LR3 dosage chartPeptideDeck · checked Oct 23, 2026