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Melanotan 1 vs PT-141

Updated 7 sources

Key differences

  1. 1Both share melanocortin ancestry with MT2. PT-141 targets desire (MC3R/MC4R) and tans minimally; MT1 prefers MC1R, the pigment receptor.
  2. 2Each has one approval: Scenesse for EPP, Vyleesi for low sexual desire in women.

Side by side

Facts from each record, in the same words as their own pages.
Melanotan 1 and PT-141 side by side
Melanotan 1PT-141
Category
  • Skin & hair
  • Sexual health
Evidence
  • Strong human trials
  • Strong human trials
FDA status
  • FDA approved as ScenesseRegulatory
  • FDA approved as VyleesiRegulatory
WADA
  • Not prohibited
  • Not confirmed
Half-life
  • 0.8 to 1.7 hours (beta phase) after a plain subcutaneous injection, in 3 men; subcutaneous dosing was fully bioavailable.Clinical study
  • About 15 hours apparent half-life from the Scenesse implant, with peak levels at a median 36 hours.Regulatory
  • About 2.7 hours (range 1.9 to 4.0) after a subQ shot, peaking around 1 hour. SubQ bioavailability is about 100%.Regulatory
Routes
  • Subcutaneous injection
  • Subcutaneous injection, Nasal
Forms
  • Other form, Vial (powder)
  • Prefilled pen, Vial (powder), Nasal spray, Other form
Reported doses
  • 0.25 to 16 mg (subcutaneous injection)
  • 0.08 to 0.21 mg/kg (subcutaneous injection)
  • 250 to 1,000 mcg (subcutaneous injection)
  • 0.3 to 10 mg (subcutaneous injection)
  • 7.5 to 20 mg (nasal)
  • 500 to 1,500 mcg (subcutaneous injection)
Most cited frequency
  • One implant every 2 months; in the EU 3 implants a year are recommended, 4 at most
  • As needed. No more than 1 dose in 24 hours; more than 8 doses a month is not recommended.
Vial sizes
  • 10 mgCompetitor guide
  • 10 mgCompetitor guide
Mixed vial keeps
  • Research vials after mixing: 2 to 8 C.Competitor guide
  • Keep the mixed vial at 2 to 8 C and do not freeze it.Competitor guide
Protocols on file
  • 8
  • 9

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

7 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide1

  1. Melanotan 2 (MT-2) Peptide Guide (MT-2 vs PT-141 vs afamelanotide)peptidedosingprotocols.com · checked Oct 24, 2026