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Kisspeptin vs PT-141

Updated 10 sources

Key differences

  1. 1PT-141 is an approved, on-demand desire drug for women that acts on melanocortin receptors.
  2. 2Kisspeptin is unapproved; its desire data come from single 75-minute IV infusions of kisspeptin-54 in brain-scan trials of men and women with low desire.
  3. 3PT-141 is an on-demand desire trigger. Kisspeptin works upstream on the hormone axis.

Side by side

Facts from each record, in the same words as their own pages.
Kisspeptin and PT-141 side by side
KisspeptinPT-141
Category
  • Sexual health, Other
  • Sexual health
Evidence
  • Limited human data
  • Strong human trials
FDA status
  • FDA 503A Category 2Regulatory
  • FDA approved as VyleesiRegulatory
WADA
  • Prohibited
  • Not confirmed
Half-life
  • About 4 minutes in human plasma (kisspeptin-10)Clinical study
  • 27.6 minutes for kisspeptin-54, the longer form used in fertility trialsClinical study
  • Under 1 minute in rats after an IV dose (kisspeptin-10)Regulatory
  • About 2.7 hours (range 1.9 to 4.0) after a subQ shot, peaking around 1 hour. SubQ bioavailability is about 100%.Regulatory
Routes
  • Subcutaneous injection, Intravenous (IV)
  • Subcutaneous injection, Nasal
Forms
  • Vial (powder), Ready-to-use vial, Other form
  • Prefilled pen, Vial (powder), Nasal spray, Other form
Reported doses
  • 50 to 200 mcg (subcutaneous injection)
  • 0.01 to 3 mcg/kg (intravenous (iv))
  • 1.5 to 4 mcg/kg/hour (intravenous (iv))
  • 0.3 to 10 mg (subcutaneous injection)
  • 7.5 to 20 mg (nasal)
  • 500 to 1,500 mcg (subcutaneous injection)
Most cited frequency
  • Once daily
  • As needed. No more than 1 dose in 24 hours; more than 8 doses a month is not recommended.
Vial sizes
  • 10 mgCompetitor guide
  • 10 mgCompetitor guide
Mixed vial keeps
  • Keep the mixed vial at 2 to 8 C and do not freeze it.Competitor guide
  • Keep the mixed vial at 2 to 8 C and do not freeze it.Competitor guide
Protocols on file
  • 10
  • 9

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

10 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Community-reported1

  1. Comment: PT-141 vs kisspeptinr/Peptides · checked Oct 23, 2026