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NAD+ vs SS-31

Updated 12 sources

Key differences

  1. 1NAD+ is a coenzyme for sirtuins and DNA repair, given IV, under the skin or as oral precursors like NMN and NR.
  2. 2NAD+ costs far less per mg. SS-31 is a drug aimed at the mitochondrial membrane.

Side by side

Facts from each record, in the same words as their own pages.
NAD+ and SS-31 side by side
NAD+SS-31
Category
  • Longevity, Cognitive
  • Longevity
Evidence
  • Limited human data
  • Some human trials
FDA status
  • FDA 503A Category 1Regulatory
  • FDA approved as ForzinityRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • Not established. No study reports human kinetic values for injected NAD+, per a 2026 review. In one IV study, plasma levels stayed flat for the first 2 hours of a 6-hour infusion.Clinical study
  • About 3 to 4 hours in plasma per FDA. A 2021 paper cites a 16-hour half-time in human blood, and dogs given it IV showed about 4 hours. Sources disagree.Clinical study
Routes
  • Subcutaneous injection, Intramuscular injection, Intravenous (IV), Nasal
  • Subcutaneous injection, Intravenous (IV)
Forms
  • Vial (powder), Nasal spray
  • Vial (powder), Other form
Reported doses
  • 25 to 500 mg (subcutaneous injection)
  • 50 to 100 mg (intramuscular injection)
  • 250 to 1,000 mg (intravenous (iv))
  • 0.5 to 80 mg (subcutaneous injection)
  • 0.5 mg/kg (intravenous (iv))
  • 100 to 500 mcg (subcutaneous injection)
Most cited frequency
  • Twice a week
  • Once daily
Vial sizes
  • 100 mg, 250 mg, 500 mg, 750 mg, 1,000 mg, 1,500 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mg, 40 mg, 50 mgCompetitor guide
Mixed vial keeps
  • Fridge at 2 to 8 C, out of light, never frozen.Competitor guide
  • Fridge, 2 to 8 C, out of light.Competitor guide
Protocols on file
  • 19
  • 35

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

12 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Clinical study4

  1. Narrative review of IV NAD+ (2026)Frontiers in Aging · checked Oct 23, 2026
  2. Grant et al. 2019, IV NAD+ pilotPMC · checked Oct 23, 2026
  3. Roshanravan B et al. 2021, in vivo mitochondrial ATP production improved after a single dose of elamipretidePubMed Central · checked Oct 23, 2026
  4. SS-31, Cognitive Vitality for ResearchersAlzheimer's Drug Discovery Foundation, via a reference work · checked Oct 23, 2026

Competitor guide2

  1. NAD+ and SS-31 stack protocolpathtopeptides.com · checked Oct 23, 2026
  2. Alternatives to SS-31bodyhackguide.co · checked Oct 23, 2026