NAD+

Most guides say 5 mL. That makes 100 mg/mL, so 1 unit on a U-100 insulin syringe is 1 mg and a 50 mg dose is 50 units. Some guides use 3 mL, which makes about 167 mg/mL and gets close to the strength where crystals become a problem in the fridge. Use the calculator for any other mix.

Most home subQ use sits at 25 to 100 mg a shot. Guides start around 25 mg twice a week, and 50 mg 3 times a week is where most home plans land. Raise about 25 mg at a time if it goes well. No human study has set a subQ dose, so all of this is convention.

Two to three times a week is the norm. Some guides go daily, at 100 to 250 mg, and one guide runs a 16-week daily ramp. Weekly totals across guides range from 50 mg to 1,750 mg, which shows how loose the convention is.

NAD+ is acidic, and a fast push makes it worse. Posters on r/Peptides fix it by adding more water and pushing slower. Buffered NAD+ is said to mix near pH 7 to 8.5 instead of 3 to 4, which stings less.

Several r/Peptides users describe sudden whole-body cramping a few minutes after pushing NAD+ fast, gone within about 2 to 5 minutes. The usual fix is a much slower push: inject a little, wait a minute or two, then finish over several minutes. After a bad one, posters restart at 15 to 25 mg.

It is too concentrated for the cold. One user put 5 mL in a 1,000 mg vial (200 mg/mL) and got crystals. Replies point at anything above about 250 mg/mL when chilled and say to use more water.

Morning. NAD+ keeps a lot of people awake when taken later, and a few report it even with a 7 am dose. Guides say the same.

Users on r/Peptides lean toward injection. Nasal sprays deliver about 5 mg per spray, so even a 20 mg day is small next to a 50 to 100 mg shot. No human study has measured blood NAD+ after a nasal dose.

Compounding pharmacies make them at 300 mg/mL in a 15 mL bottle. Research sprays run weaker, for example 500 mg in 10 mL (50 mg/mL), about 5 mg per 0.1 mL spray. Check the label before you count sprays.

No. It is a coenzyme every cell uses to make energy and run repair enzymes like sirtuins and PARPs. It sits next to peptides because it is sold the same way: powder in a vial, mixed with bacteriostatic water, drawn with an insulin syringe.

Users on r/Peptides say no. We found no data either way.

One guide says 2 to 4 weeks for subQ. Another says hours to a day after an IV session.

About 4 weeks in the fridge by convention. Guides range from 7 to 30 days, and none has stability data. Toss it if it turns yellow or brown, cloudy or grainy.

IV is 250 to 1,000 mg over 1 to 4 or more hours in a clinic, at roughly $300 to $1,000 a session. SubQ is 25 to 100 mg at home, at about $2 to $8 per 100 mg. No human study has compared them head to head. A registered trial is now set up to test IM, subQ and IV push.

Pharmacy guidance starts around 20 mg and works up toward 100 mg, and puts about 300 mg a week subQ as the ceiling without further evaluation. One competitor guide uses the same 300 mg figure.

The small studies so far favor NR. In Reyna 2026, NR went in over 37 minutes against 97 for NAD+, and every NAD+ client had moderate to severe symptoms during the drip. In a 2024 preprint, NR IV raised blood NAD+ 20.7% at 3 hours and beat NAD+ IV, which also caused more and stronger infusion reactions.

No. FDA has received reports of severe chills, shaking, vomiting and fatigue after NAD+ injectables that fit endotoxin contamination, and warned compounders off food-grade NAD+. A January 2026 warning letter describes 3 people sent to the ER with low blood pressure and shaking after one lot. Normal NAD+ effects are sting, cramping on a fast push and restlessness.

No injectable NAD+ product is FDA approved. NAD sits in Category 1 (under evaluation) on FDA's 503A list updated May 14, 2026, so 503A pharmacies can compound it under the interim policy. It is not on the 503B bulks list. Oral NMN was declared lawful in supplements in September 2025.

We found no listing of NAD+ itself. The catch is the drip: IV infusions over 100 mL per 12 hours are a prohibited method outside hospital care, surgery or diagnostics, and a typical NAD+ drip is 250 to 500 mL.

It is debated. A 2026 review calls human evidence sparse and says healthy aging may not lower whole-blood NAD+. That cuts against the core pitch for topping it up.

Nobody has measured it for injected NAD+. Some guides print about 45 minutes for IV, others just say minutes, and neither cites a source. In the one IV kinetics study, blood levels stayed flat for 2 hours while it went in, then climbed.