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Animal data onlyNot FDA approved

Dihexa dosage

Also known as: PNB-0408 · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide · Dihexa acetate · Hexanoyl-Tyr-Ile-Ahx-NH2

Updated 45 sources

Every Dihexa protocol on file, 8 in all, labelled by where each number came from.

Calculate with DihexaDihexa overview

Dihexa dosage by goal

Grouped by goal. Each protocol shows the amount, how often, cycle and rest as the source states them, with every titration step.

Oral3

Oral, daily (user reports)

Amount
5 to 15 mg
How often
Once daily
Route
Oral, capsule
Cycle
About 2 to 4 weeks reported; one plan was 1 month on, 1 month off

Note: Users report 5 mg a day for two weeks, 10 mg a day planned as 1 month on and 1 off, and 15 mg a day for 20 days. A few go far higher, such as 40 mg a day.

Oral, spaced doses (user reports)

Amount
10 to 20 mg
How often
Once to three times a week, or about every 3 days
Route
Oral, capsule
Cycle
4 to 6 weeks, 8 at most, in one plan

Note: Spacing rests on the belief that Dihexa lasts for days. That belief comes from a rat study; in people the half-life of Dihexa itself has never been measured.

Oral, weekly ladder (guide)

Amount
10 to 100 mg
How often
Once to three times a week, never daily
Route
Oral, capsule
Cycle
4 to 8 weeks on
Rest
4 weeks off

Timing: Morning, on an empty stomach.

Note: Start at 10 to 20 mg once a week and climb toward 50 to 100 mg. The same page's FAQ contradicts this with 10 to 20 mg a day and 1 to 5 mg by injection. The top of this ladder is far above what users report.

Transdermal in DMSO2

Transdermal in DMSO, daily (user reports)

Amount
4 to 40 mg
How often
Once daily, rubbed on thin skin
Route
Topical, topical
Cycle
1 to 6 weeks reported

Timing: Inner elbows, forearms, backs of hands or neck.

Note: Reports include 4 mg each morning, 20 mg a day for 6 weeks, 10 mg every other day for 3 weeks, about 25 mg a day and 40 mg a day for about 10 days. Several felt little at first and noticed changes weeks later.

Transdermal in DMSO, spaced (user report)

Amount
25 to 40 mg
How often
Every 8 to 10 days
Route
Topical, topical

Note: One user's schedule, based on the long half-life seen in rats.

Other protocols: oral, capsule1

Most cited range

Amount
5 to 20 mg
How often
Once daily
Route
Oral, capsule

Note: New users start near 5 mg; some references go to 20 to 30 mg. Every figure traces to vendor copy and forums such as LongeCity. Also used sublingually and on the skin in DMSO.

Other protocols: topical, topical1

Transdermal cream (guide)

Amount
1 to 5%
How often
1 to 3 times a week
Route
Topical, topical
Cycle
4 to 8 weeks on
Rest
4 weeks off

Timing: A pea-sized amount on thin skin such as the inner wrist or forearm.

Note: A 1 to 5% cream is 10 to 50 mg per gram, compounded in a DMSO or penetration-enhancer base. The guide's instructions say 1 to 3 times a week and never daily, while its summary table says once daily. It gives no mg amount per application.

Other protocols: sublingual1

Sublingual (user reports)

Amount
1 to 15 mg
How often
Every 2 to 3 days
Route
Sublingual

Note: Reports include 10 mg every second day, 15 mg spaced to make up for poor sublingual uptake, and a homemade DMSO solution at 1 to 2 mg every 2 to 3 days. Dihexa does not dissolve in water, so users dissolve it in DMSO first.

Doses shown are what sources report, labelled by origin. Not medical advice.

Mixing Dihexa

Diluent: DMSO (not bacteriostatic water)

Dihexa does not dissolve in bacteriostatic water. Users dissolve powder in pharma-grade DMSO, sometimes with PEG400, glycerin or ethanol, then apply it to skin, put it under the tongue or into a gel cap. One user got 50 mg into 1 mL of 99% DMSO.

Dihexa dosage questions

What dose of Dihexa do people take?

There is no tested human dose. The most cited range is 5 to 20 mg once a day, with new users near 5 mg and some going to 20 to 30 mg. Others space 10 to 20 mg one to three times a week. All of it comes from vendors and forums.

Can Dihexa be injected or mixed with bacteriostatic water?

It does not dissolve in bacteriostatic water. Users dissolve it in DMSO, and injection-grade DMSO is hard to find, so most people with 10 mg vials end up using it on the skin or under the tongue.

Sources for these doses

18 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide1

  1. Dihexa protocol guidepathtopeptides.com · checked Oct 24, 2026

Community-reported17

  1. Dihexa dosage: what the community reportsthepeptidecatalog.com, via a competitor guide · checked Oct 24, 2026
  2. Dihexa research guidepeptidedeck.com, via a competitor guide · checked Oct 24, 2026
  3. Dihexa 2 week reportr/NooTopics · checked Oct 24, 2026
  4. Dihexa capsules guide (comment, 10 mg daily)r/LAPeptidesGuide · checked Oct 24, 2026

Back to the full Dihexa page for side effects, storage, stacks and legal status.