Selank

Most guides land at 250 to 500 mcg per nasal dose, 2 to 3 times a day, or 250 to 500 mcg once a day by injection. The full spread runs from 100 to 1,000 mcg per dose and 200 to 2,700 mcg a day. The 2,700 mcg figure comes from a small Russian anxiety study as cited by guides.

The Russian label and every human trial use the nose. Users split both ways: some find nasal stronger and subQ useless, others the reverse. One commenter claims subQ needs 1.5 to 2 times the nasal dose, with no source behind it.

The maker says 5 to 20 minutes in healthy people. In anxiety disorders, about half respond on day 1 and the rest from day 3. Users report anything from 5 to 10 minutes to only feeling it on a second cycle.

Minutes. The Russian label says nasal Selank appears in plasma within 30 seconds and its level falls over 5 to 5.5 minutes. Guide figures, mostly unsourced, run from about 2 to 10 minutes: 2 to 10, 2 to 5, about 3, about 2 in the lab, and 2 to 3. It breaks down into short fragments (TKPRP, TKP, RP, GP).

In the blood, minutes. The effect lasts longer: the maker says up to 24 hours. Guides say 3 to 6 hours or 12 to 24 hours. Users report about 3 to 4 hours nasal and 4 to 5 hours or all day subQ.

Both are common on r/Peptides. Some take 250 mcg before stressful events. Others run it daily, for example 500 mcg 5 days a week.

It depends on the mix and the pump. Most pumps deliver about 0.1 mL, so a 2 mg/mL spray gives about 200 mcg per spray. Pump output ranges from about 0.025 to 0.20 mL by device. Ready-made sprays seen by users deliver 50 or 100 mcg per spray.

Common recipes: 10 mg in 5 mL gives about 200 mcg per 0.1 mL spray; 10 mg in 10 mL gives 100 mcg; 10 mg in 6.67 mL gives 150 mcg. Some dissolve 10 mg in 2 mL bacteriostatic water and add 8 mL saline. For a 5 mg vial, 4 mL gives 125 mcg per spray and 2 mL gives 250 mcg. Calibrate your pump on a known volume before trusting the math.

It works, but users report it burns and can cause nosebleeds. Many use sterile saline or sterile water instead and keep the spray in the fridge.

The Russian drops keep at 25 C or below for 15 days once opened. DIY sprays: yes. Users say refrigerate and discard after 30 days or if the liquid turns cloudy or smells off. Saline sprays have no preservative, so the fridge matters more. One user claims 60 to 90 days. Another found mold in the pump head and swaps it every 2 to 3 weeks.

No effect is the most common complaint on r/Peptides. Reports include nothing at up to 2 mg subQ or 600 mcg nasal, nothing after 7 weeks at 1 mg, and nothing after 2 weeks at 500 mcg. One user felt nothing until a second cycle. Some find a route switch helps.

The label says there is no dependence or habituation. Users mostly report no tolerance, including one who ran 500 mcg 5 days a week for 2 years. A thread titled 'stopped working after 2 days' exists, but its post was removed.

None per the label. Some users notice stress returning after they stop. Users say the effect lingers 1 to 2 days to 2 to 3 weeks after stopping. In the phenazepam trial, the anti-anxiety effect lasted a week after the last dose.

The label runs 14-day courses with 1 to 3 weeks between them. User patterns include 500 mcg daily for 40 days, 2 weeks off, then repeat; 4 weeks on and 4 off; 5 weeks on and 2 to 4 off; 6 weeks on every 3 months. One user runs it 5 days a week with no breaks.

There is no interaction data for these drug classes. The label says Selank combines with any psychoactive or neuroactive therapy. Users warn about serotonin effects, and coming off SSRIs with Selank is a frequent forum topic. Talk to your prescriber before changing an antidepressant.

The maker says yes and claims it reduces alcohol toxicity. No independent data back that claim.

Yes, per the label, which says it is not sedating.

Only a few anecdotal reports exist, usually from people on other compounds too. Semax gets blamed more often. No study reports it.

There is no data either way. No clinical or preclinical study exists on the acetylated form, and the stronger, longer-lasting claims are unsourced. User reports are mixed.

It is not FDA approved and is sold as a research chemical. FDA lists Selank acetate as nominated for compounding and then withdrawn, and says it lacks important human safety information. In Russia it is a registered over-the-counter nasal drop.