Semax

The Russian label uses 400 to 900 mcg a day for mental fatigue, split into 2 to 3 doses before midday. Its stroke doses run 6,000 to 20,000 mcg a day. On r/Peptides, 200 to 600 mcg a day is typical, and most guides cluster at 200 to 600 mcg for focus.

The Russian product is nasal only, and the FDA found no human safety data for injecting it. Users split: some say subQ works where nasal did nothing, others prefer nasal because they feel it in about 30 seconds versus 3 to 5 minutes for subQ.

Per the label, one drop of 0.1% is 50 mcg and one drop of 1% is 500 mcg. One guide says about 30 mcg per 0.1% drop. Premixed research sprays at 30 mg per 10 mL give about 300 mcg per pump. Pumps deliver about 0.1 to 0.13 mL per press by user reports, and 0.025 to 0.20 mL across devices, so count presses on a known volume to calibrate.

One guide dissolves 10 mg in 3 mL, then tops up with sterile saline to 5 mL for 200 mcg per 0.1 mL spray, or to 10 mL for 100 mcg per spray. One user mixes to 250 mcg per spray. Calibrate your pump before trusting the math.

Nobody has measured it in people; the FDA found no human pharmacokinetic studies. In rats, brain levels peak 2 minutes after a nasal dose and the peptide is quickly broken down, mostly to Pro-Gly-Pro. Guide figures disagree wildly and cite nothing: about 7 minutes, 2 to 3 minutes, minutes, or several hours.

The developers report effects lasting 20 to 24 hours in animals and people. The peptide itself is cleared fast: guides say about 2 to 7 minutes, and in rats it is broken down soon after reaching the brain. No human pharmacokinetic study exists.

In the morning or the first half of the day, per the label. Guides say take any second dose before 2 to 3 PM and avoid dosing near bedtime.

Some users feel it the same day in about 20 minutes. Others say it took 4 to 7 days. Plenty report a subtle effect or none at all.

Label courses run 3 to 14 days and can be repeated. Users run 4 weeks on and 4 off, a month on and a month off, or the first ten days of every month. Guides range from 10 to 14 days up to 4 to 6 weeks, with breaks about as long.

Only in anecdotes. Neither the Russian label nor any study reports it, and guides disagree on whether to list it at all.

Some users report anxiety, agitation and a raised heart rate. The label lists anxiety disorders as a reason not to use it. Many users pair it with Selank to take the edge off.

It is the most common stack. Users usually take Semax in the morning and Selank later or as needed. Many advise trying each alone first and taking them separately so each dose can be tuned.

One r/Peptides user says the effect drops sharply after the first or second vial. Cycling off is the usual answer.

No. It was nominated for compounding and then withdrawn, and FDA flags immunogenicity risk. FDA staff told the July 2026 advisory committee the balance weighs against adding it to the compounding list, but the committee voted to recommend it, reportedly 8 to 5. That vote is non-binding. In Russia it is a registered drug and on the essential drugs list since 2011.

Russian drops: cold, dark, never frozen. Powder: freezer long term, fridge short term. Mixed for injection: fridge, about 3 to 4 weeks, and users say 4 weeks at most. An opened Russian bottle: 30 days, per one guide. Homemade sprays: guides say 14 days to 4 weeks in the fridge. The FDA notes spray containers and pumps are untested for stability.

Guides claim it is 2 to 3 times stronger per mcg and users say it hits harder. There is no human data. One lab study found acetylation removed Semax's cell-protection effect.