Also known as: Delta sleep-inducing peptide · Emideltide · Emideltide acetate · Deltaran
Updated 70 sources
Every DSIP protocol on file, 20 in all, labelled by where each number came from. 1 have titration steps, each step is worked out in U-100 units for a 2 mg vial + 1 mL water.
Who: First-time users in guide protocols.
Timing: 30 to 60 minutes before bed in one guide, 30 minutes in another.
Note: Not validated in any trial. Every human study gave DSIP by IV, so these subQ doses are guide conventions.
Timing: 30 to 60 minutes before bed.
Timing: 30 to 60 minutes before bed.
Note: One guide sets 300 mcg as a hard cap. The same page gives both 2 and 2 to 3 weeks off.
Timing: Evening, 30 to 60 minutes before bed.
| When | Dose | U-100 units (2 mg vial + 1 mL water) |
|---|---|---|
| Week 1 | 100 mcg | 5 units · 0.05 mL |
| Week 2 | 150 mcg | 7.5 units · 0.075 mL |
| Week 3 | 200 mcg | 10 units · 0.1 mL |
| Weeks 4 to 8 | 250 mcg | 12.5 units · 0.125 mL |
Note: Weeks 4 to 8 run 250 to 300 mcg; the titration shows the low end. No rest period is given.
Timing: Evening.
Note: The page itself says these doses go beyond the studied range. No source is given for them.
Timing: 30 to 40 minutes before bed.
Note: The same guide lists intranasal use at the same dose.
Timing: Preferably 3 hours before bedtime.
Timing: 1 to 3 hours before sleep.
Note: Lower range 100 to 200 mcg, higher range 200 to 300 mcg.
Timing: Before sleep.
Note: 100 mcg conservative, 100 to 250 mcg standard, 250 to 300 mcg upper.
Who: Community protocols aggregated on a guide site.
Timing: 30 to 60 minutes before bed.
Who: Community protocols aggregated on a guide site.
Timing: Before bed.
Note: Morning grogginess is reported more above 300 mcg.
Who: Community protocols aggregated on a guide site.
Timing: Evening.
Who: Self-reports on r/Peptides, 2024 to 2026.
Timing: Anywhere from 20 minutes to 3 hours before bed in posts.
Note: Most start at 100 mcg and move to 150 to 250 mcg if that feels too light. One site's tally of about 50 self-reports puts the median at 200 to 400 mcg per shot, with a range of 25 to 600 mcg. Some users only feel it at 700 mcg to 1 mg, and one went to 2.5 mg with no tracker change.
Who: A self-experimenter newsletter and r/Peptides users who went above 300 mcg.
Timing: 30 to 60 minutes before bed; the author says some people need about 3 hours.
Note: The author calls 500 mcg to 1 mg the sweet spot and says no cycling is needed. On r/Peptides, one user felt it clearly at 700 mcg to 1 mg; others saw nothing at 500 mcg, and 750 mcg brought mild bad dreams.
Timing: About 30 minutes before bed.
Note: 20 mcg per spray, so 40 mcg for two. The spray also carries GABA 10 mg and melatonin 100 mcg per spray. That is a tiny fraction of the IV trial dose, and no human nasal data exists.
Timing: The guide warns against dosing too close to bedtime.
Note: Lists subQ or intranasal use.
Who: Community protocols aggregated on a guide site.
Who: A self-experimenter newsletter, tier 1.
Timing: Ahead of an expected stressful event.
Who: Small trials of 6 to 16 people with chronic insomnia, plus 6 healthy volunteers.
Timing: Varied by trial: a slow morning infusion in healthy volunteers, over 4 minutes before bed for 4 nights, or in the afternoon before nights 3 to 5.
Note: The trials dosed 25 nmol/kg, which FDA converts to 21.3 mcg/kg; one used 30 nmol/kg for 7 nights. That is well above the usual subQ dose. FDA's pooled IV data covers 209 people at 25 to 150 nmol/kg for 1 to 15 days.
Who: 107 inpatients withdrawing from alcohol or opiates (Dick 1984).
Note: 25 nmol/kg per injection. Medically supervised hospital use, not a home protocol. Community sources give no withdrawal dose.
Doses shown are what sources report, labelled by origin. Not medical advice.
| Goal | Most reported amounts (mentions) |
|---|---|
| Sleep | 250 mcg (15), 100 mcg (14), 200 mcg (13), 1 mg (12) |
| Goal not stated | 500 mcg (3), 2.5 mg (2), 250 mcg (2) |
| Water | Strength | 100 mcgdose, units | 250 mcgdose, units | 300 mcgdose, units |
|---|---|---|---|---|
| 2 mg vial | ||||
| 1 mLCompetitor guide | 2 mg/mL | 50.05 mL | 12.50.125 mL | 150.15 mL |
| 5 mg vial | ||||
| 1 mLCompetitor guide | 5 mg/mL | 20.02 mL | 50.05 mL | 60.06 mL |
| 2 mLCommunity-reported | 2.5 mg/mL | 40.04 mL | 100.1 mL | 120.12 mL |
| 2.5 mLCompetitor guide | 2 mg/mL | 50.05 mL | 12.50.125 mL | 150.15 mL |
| 3 mLCompetitor guide | 1.667 mg/mL | 60.06 mL | 150.15 mL | 180.18 mL |
| 10 mg vial | ||||
| 2 mLCompetitor guide | 5 mg/mL | 20.02 mL | 50.05 mL | 60.06 mL |
| 3 mLCompetitor guide | 3.333 mg/mL | 30.03 mL | 7.50.075 mL | 90.09 mL |
| 15 mg vial | ||||
| 3 mLCommunity-reported | 5 mg/mL | 20.02 mL | 50.05 mL | 60.06 mL |
Doses shown are what sources report, labelled by origin. Not medical advice.
Calculate with this peptideYour vial, your water, your dose: DSIP in syringe units, with the math shown.Diluent: Bacteriostatic water
Water volumes sources use: 1 mL, 2 mL, 2.5 mL, 3 mL
Guides mix a 5 mg vial with 2.5 mL for an easy 2 mg per mL, or 3 mL for finer steps. A 10 mg vial usually gets 2 or 3 mL. Toss the vial if the liquid turns cloudy. FDA notes that sellers also offer premixed 2 mg/mL kits, which need no mixing.
Most guides and community posts land on 100 to 300 mcg subQ at night, usually starting at 100 mcg. Outliers run from 25 mcg to 1 mg, and one r/Peptides user tried 2.5 mg. None of these subQ doses has been tested in a trial; every human study used IV dosing at about 21 mcg per kg.
Guides commonly add 2.5 mL of bacteriostatic water, giving 2 mg per mL, so 100 mcg is 5 units on a U-100 syringe. Another option is 3 mL, where 1 unit is about 16.7 mcg. Use the calculator for your exact vial and dose.
No tolerance study exists. Advice runs from no cycling at all to 10 days on and 10 off, or 2 to 4 weeks on and 2 off. Aggregated community notes mention rebound insomnia after daily use beyond 2 to 3 weeks, and many r/Peptides users run 5 on and 2 off.
Guides give anything from 24 hours to about 28 days, and none has a stability study behind it. Keep it at 2 to 8 C, away from light, and throw it out if it turns cloudy.
35 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.
Back to the full DSIP page for side effects, storage, stacks and legal status.