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CJC-1295 vs Sermorelin

Updated 11 sources

Key differences

  1. 1Same GHRH(1-29) core. Sermorelin is unmodified and was FDA approved as Geref; Mod GRF adds four swaps that resist breakdown.
  2. 2The DAC version adds albumin binding and lasts days, not minutes.
  3. 3CJC-1295 is sermorelin's core with four amino-acid swaps (no DAC) or added albumin binding (DAC), which stretches its half-life to 5.8 to 8.1 days.

Side by side

Facts from each record, in the same words as their own pages.
CJC-1295 and Sermorelin side by side
CJC-1295Sermorelin
Category
  • GH axis
  • GH axis
Evidence
  • Limited human data
  • Some human trials
FDA status
  • Not FDA approvedRegulatory
  • Formerly approved as GerefRegulatory
WADA
  • Prohibited
  • Prohibited
Half-life
  • With DAC: 5.8 to 8.1 days in healthy adults. Without DAC: about 30 minutes per guides, never measured in humans.Competitor guide
  • Minutes. 10.4 minutes after IV dosing in rats, about 4.3 minutes in a review table, and 10 to 20 minutes per guides.Competitor guide
Routes
  • Subcutaneous injection
  • Subcutaneous injection
Reported doses
  • 0.4 to 2 mg (subcutaneous injection)
  • 100 to 400 mcg (subcutaneous injection)
  • 100 to 500 mcg (subcutaneous injection)
Most cited frequency
  • 1 to 2 mg a week, split into 1 or 2 injections
  • Once daily at bedtime
Vial sizes
  • 2 mg, 5 mgCompetitor guide
  • 5 mg, 6 mg, 10 mgCompetitor guide
Mixed vial keeps
  • Fridge, 2 to 8 °C, and avoid freeze-thaw.Competitor guide
  • Fridge, 2 to 8 °C.Competitor guide
Protocols on file
  • 9
  • 11

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

11 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory4

  1. Certain bulk drug substances, safety risksFDA · checked Oct 23, 2026
  2. 503A bulk drug substance categories (May 14, 2026)FDA · checked Oct 23, 2026
  3. Drugs@FDA Geref records (openFDA)FDA · checked Oct 23, 2026
  4. Determination that Geref was not withdrawn for safety or effectivenessFederal Register · checked Oct 23, 2026

Competitor guide4

  1. CJC-1295 no DAC dosage guideBodyHackGuide · checked Oct 23, 2026
  2. SermorelinPeptidesExplorer · checked Oct 23, 2026
  3. Sermorelin dosage guideBodyHackGuide · checked Oct 23, 2026
  4. Sermorelin dosage guidePeptideDeck · checked Oct 23, 2026