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TB-500 vs Thymosin beta-4

Updated 10 sources

Key differences

  1. 1TB-500 is a 7 amino acid fragment. Thymosin beta-4 is the full 43 amino acid protein (about 4,963 Da) found in most cells.
  2. 2Human trials used thymosin beta-4 by IV, eye drops or topical gel. Product labels blur the two.
  3. 3Thymosin beta-4 is the full 43 amino acid protein, about 4,963 Da. TB-500 is the 7 amino acid fragment Ac-LKKTETQ, about 889 Da.
  4. 4Every human trial used the full protein, by IV, gel or eye drops. Doses are not interchangeable.

Side by side

Facts from each record, in the same words as their own pages.
TB-500 and Thymosin beta-4 side by side
TB-500Thymosin beta-4
Category
  • Healing & recovery
  • Healing & recovery
Evidence
  • Animal data only
  • Some human trials
FDA status
  • Not FDA approvedRegulatory
  • In clinical trialsRegulatory
WADA
  • Prohibited
  • Prohibited
Half-life
  • Not established in humans for the fragment. Full-length thymosin beta-4 by IV lasted longer at higher doses; one guide cites 0.5 to 2.1 hours.Clinical study
  • 0.5 to about 2 hours after IV recombinant thymosin beta-4 in healthy volunteers; no subQ data.Clinical study
  • Rose with dose after IV synthetic thymosin beta-4 in healthy volunteers.Clinical study
Routes
  • Subcutaneous injection, Intramuscular injection
  • Intravenous (IV), Topical, Subcutaneous injection
Forms
  • Vial (powder)
  • Vial (powder), Topical
Reported doses
  • 1 to 5 mg (subcutaneous injection)
  • 2 to 2.5 mg (intramuscular injection)
  • 500 to 1,000 mcg (subcutaneous injection)
  • 42 to 1,260 mg (intravenous (iv))
  • 0.05 to 25 mcg/kg (intravenous (iv))
  • 0.01 to 0.1% (topical)
Most cited frequency
  • Twice weekly
  • One dose, then the same dose daily for 14 days
Vial sizes
  • 2 mg, 5 mg, 10 mgCompetitor guide
  • 5 mg, 10 mgCompetitor guide
Mixed vial keeps
  • Fridge at 2 to 8 C, dark, never frozen.Competitor guide
  • Fridge at 2 to 8 C, use within 7 to 10 days, avoid freeze-thaw.Competitor guide
Protocols on file
  • 19
  • 10

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

10 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide3

  1. TB-500 peptidepeptidedosages.com · checked Oct 23, 2026
  2. TB-500 dosage chartpeptidedeck.com · checked Oct 23, 2026
  3. TB-500 protocol (TB-500 vs thymosin beta-4 section)peptidedosingprotocols.com · checked Oct 24, 2026