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Epitalon vs FOXO4-DRI

Updated 9 sources

Key differences

  1. 1Opposite strategies: epitalon is pitched as keeping cells alive longer through telomerase, while FOXO4-DRI removes senescent cells.
  2. 2Both rest on animal data. Guides often run FOXO4-DRI first and epitalon after.

Side by side

Facts from each record, in the same words as their own pages.
Epitalon and FOXO4-DRI side by side
EpitalonFOXO4-DRI
Category
  • Longevity, Sleep
  • Longevity
Evidence
  • Limited human data
  • Animal data only
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • Not established. A 2026 review says absorption, clearance and terminal half-life remain undefined in humans.Clinical study
  • Not published for people or animals. D-amino acids resist protein-cutting enzymes, which guides say may extend its activity.Competitor guide
Routes
  • Subcutaneous injection, Oral, Intramuscular injection, Other route
  • Subcutaneous injection
Forms
  • Vial (powder), Capsule, Nasal spray, Oral solution
  • Vial (powder)
Reported doses
  • 0.5 to 10 mg (subcutaneous injection)
  • 0.5 to 10 mg (oral)
  • 100 to 1,000 mcg (subcutaneous injection)
  • 1 to 25 mg (subcutaneous injection)
  • 250 to 500 mcg (subcutaneous injection)
Most cited frequency
  • Once daily in the evening
  • Every other day for 3 doses
Vial sizes
  • 10 mg, 50 mg, 100 mgCompetitor guide
  • 10 mgCompetitor guide
Mixed vial keeps
  • Fridge at 2 to 8 C, never frozen, no freeze-thaw.Competitor guide
  • Fridge, 2 to 8 C, never frozen, kept dark.Competitor guide
Protocols on file
  • 23
  • 7

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

9 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide4

  1. FOXO4-DRI: the senolytic peptide that restored old mice in one studypeptidebreakdown.com · checked Oct 24, 2026
  2. FOXO4-DRI dosage guide: senolytic protocolspeptidewiki.co · checked Oct 24, 2026
  3. FOXO4-DRIpeptiq.io · checked Oct 24, 2026
  4. FOXO4-DRI quick start protocolpeptidedosingprotocols.com · checked Oct 24, 2026