FOXO4-DRI vs Humanin

Name: FOXO4-DRI vs Humanin
Published: 2026-10-24

Updated Oct 24, 20269 sources

Key differences

1Humanin blocks cell death; FOXO4-DRI triggers it in senescent cells.
2Humanin is made by the body and measured in human blood. FOXO4-DRI is fully synthetic, built from D-amino acids.
3Opposite jobs: humanin helps stressed cells survive, FOXO4-DRI makes senescent cells die.
4Humanin is made by the body and measured in human blood. FOXO4-DRI is a synthetic D-amino acid peptide.

Facts from each record, in the same words as their own pages.

FOXO4-DRI and Humanin side by side
	FOXO4-DRI	Humanin
Category	Longevity	Longevity, Cognitive
Evidence	Animal data only	Animal data only
FDA status	Not FDA approvedRegulatory	Not FDA approvedRegulatory
WADA	Not confirmed	Not confirmed
Half-life	Not published for people or animals. D-amino acids resist protein-cutting enzymes, which guides say may extend its activity.Competitor guide	About 30 minutes, stated in a 2020 mouse paper's discussion, which does not say whether it means native humanin or HNGClinical study HNG lasts longer in rats than in mice, and longer when it cannot bind IGFBP-3; no human dataClinical study About 3 hours, labelled an estimate with no source givenCompetitor guide
Routes	Subcutaneous injection	Subcutaneous injection
Forms	Vial (powder)	Vial (powder)
Reported doses	1 to 25 mg (subcutaneous injection) 250 to 500 mcg (subcutaneous injection)	0.5 to 5 mg (subcutaneous injection) 25 to 500 mcg (subcutaneous injection)
Most cited frequency	Every other day for 3 doses	Once daily
Vial sizes	10 mgCompetitor guide	5 mg, 10 mg, 15 mg, 20 mgCompetitor guide
Mixed vial keeps	Fridge, 2 to 8 C, never frozen, kept dark.Competitor guide	Fridge, 2 to 8 C.Competitor guide
Protocols on file	7	10

Doses shown are what sources report, labelled by origin. Not medical advice.

9 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.