Epitalon

It depends on whose numbers you use. Most guides say 5 to 10 mg a day by injection for 10 to 20 days. Sleep users on r/Peptides mostly run 100 to 500 mcg. The two human studies of synthetic epitalon used 0.01 mg a day by IM injection and 0.5 mg a day under the tongue. No human dose-finding study exists.

It appears to come from epithalamin, the bovine pineal extract epitalon was modeled on. Reviews of the Russian trials give epithalamin IM at 5 to 10 mg a day for 10 to 20 days, and one 3-year trial used 10 mg IM shots. The only published systemic doses of synthetic epitalon in humans are 0.01 mg IM and 0.5 mg under the tongue, roughly 10 to 1,000 times lower. Whether the extract figure transfers to the pure peptide has never been tested.

No, the 10 mg figure is real. A Russian speaker on r/Peptides posted the original paper showing 10 mg a day for 10 days by IM. The top replies point out that regimen was for epithalamin, the extract, not epitalon. A 2026 review agrees the human epitalon studies used far lower doses.

Reddit is split about 100-fold. One camp runs micrograms for sleep, often 100 to 500 mcg. The other runs 5 to 10 mg for longevity. Microgram users argue the synthetic peptide is more potent than the extract; milligram users answer that nobody has shown that. Neither side has a study behind its number.

10 to 20 days is the convention. Shorter courses use higher daily doses, such as 10 mg for 10 days against 5 mg for 20.

Guides say 1 to 3 times a year, with 3 to 6 or 4 to 6 months between courses. Some guides contradict themselves on this within the same page.

Evening is the default, chosen to line up with the nightly melatonin rhythm. It has never been tested head to head. A noticeable minority on r/Peptides dose in the morning because evening doses disrupt their sleep.

2 mL is most common and makes 5 mg/mL, so 5 mg is 100 units on a U-100 syringe. 1 mL makes 10 mg/mL. For a 50 mg vial, guides use 5 mL (10 mg/mL) or 2 mL (25 mg/mL). Use the calculator for any other mix.

More than people expect. At 5 mg a day, a 10 mg vial lasts 2 days, so a 20-day course needs about 10 vials. One guide points out that the popular 10 mg for 10 days table runs into the same vial problem. Over-buying is also common: r/PeptideGuide has posts from people who bought 10 vials when they needed 4.

Epitalon and epithalon are the same molecule spelled two ways, also called AEDG. Epithalamin is the different parent product: a crude extract of bovine pineal glands. Epitalon was designed from its amino acid makeup.

Not shown. Telomerase and telomere results come from cell cultures, including one independent 2025 study whose first three figures were later replaced. No human trial has measured telomeres before and after a course.

Sleep is the effect users report most. It is also where the best human data sits: night melatonin rose in older adults who started with low pineal output, and a melatonin marker rose about 1.7-fold in night-shift workers on 0.5 mg a day. That is a biomarker, not a sleep trial.

That is the most common report, per one guide. One r/Peptides user took 8 mg a day for 20 days and noticed nothing but the injections.

Mostly mild: site redness, sleepiness in the first days, vivid dreams and the odd headache. One app logs 155 user reports of site irritation, and an r/PeptideGuide user got headaches a couple of hours after 1 mg evening doses. Single users report feeling over-sedated at higher doses, sleep that shifts or breaks when dosing late, and a raised resting heart rate. Small human studies saw no clear adverse effects but tracked them poorly.

Unknown. In mice it went with fewer chromosome aberrations and less leukemia, without changing total tumors. But telomerase activation is a theoretical risk, a 2025 cell study saw telomeres lengthen in breast cancer lines, and FDA advisory committee members cited carcinogenicity.

Unproven. One guide says nasal takes 2 to 3 times the injected dose but gives no figure, and the epithalamin trials used 10 to 30 mg a day intranasally. One guide calls oral bioavailability essentially zero, though a human study used 0.5 mg under the tongue. Sprays are sold as 100 mg bottles without a stated strength.

Not approved, and not yet compoundable. FDA dropped it from Category 2 on April 15, 2026 after the nomination was withdrawn, which did not put it on the bulks list. In July 2026 an FDA advisory committee voted 7 to 5 to recommend it for insomnia, against staff advice. The vote is non-binding, and no final listing existed as of October 2026.

Not established. A 2026 review says absorption, clearance and half-life remain undefined. Guides contradict each other: one prints about 3 hours as an estimate, two say on the order of minutes without validation, and one says no figure has been published.

Guides range from 1 to 2 weeks up to 30 days in the fridge. None has stability data. Keep it at 2 to 8 C, never freeze it, and toss it if it turns cloudy.