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Humanin vs SS-31

Updated 13 sources

Key differences

  1. 1Humanin is a signalling peptide that acts on cell receptors; SS-31 sits on the inner mitochondrial membrane and stabilises cardiolipin.
  2. 2Humanin has never been given to people in a trial.

Side by side

Facts from each record, in the same words as their own pages.
Humanin and SS-31 side by side
HumaninSS-31
Category
  • Longevity, Cognitive
  • Longevity
Evidence
  • Animal data only
  • Some human trials
FDA status
  • Not FDA approvedRegulatory
  • FDA approved as ForzinityRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • About 30 minutes, stated in a 2020 mouse paper's discussion, which does not say whether it means native humanin or HNGClinical study
  • HNG lasts longer in rats than in mice, and longer when it cannot bind IGFBP-3; no human dataClinical study
  • About 3 hours, labelled an estimate with no source givenCompetitor guide
  • About 3 to 4 hours in plasma per FDA. A 2021 paper cites a 16-hour half-time in human blood, and dogs given it IV showed about 4 hours. Sources disagree.Clinical study
Routes
  • Subcutaneous injection
  • Subcutaneous injection, Intravenous (IV)
Forms
  • Vial (powder)
  • Vial (powder), Other form
Reported doses
  • 0.5 to 5 mg (subcutaneous injection)
  • 25 to 500 mcg (subcutaneous injection)
  • 0.5 to 80 mg (subcutaneous injection)
  • 0.5 mg/kg (intravenous (iv))
  • 100 to 500 mcg (subcutaneous injection)
Most cited frequency
  • Once daily
  • Once daily
Vial sizes
  • 5 mg, 10 mg, 15 mg, 20 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mg, 40 mg, 50 mgCompetitor guide
Mixed vial keeps
  • Fridge, 2 to 8 C.Competitor guide
  • Fridge, 2 to 8 C, out of light.Competitor guide
Protocols on file
  • 10
  • 35

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

13 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Competitor guide1

  1. Humaninpeptiq.io · checked Oct 24, 2026

Community-reported1

  1. Humanin: community protocols and reportspeptideprotocolwiki.com, via a competitor guide · checked Oct 24, 2026