FOXO4-DRI vs MOTS-c

Name: FOXO4-DRI vs MOTS-c
Published: 2026-10-24

Updated Oct 24, 20268 sources

Key differences

1MOTS-c is a mitochondrial signal for energy metabolism; FOXO4-DRI kills senescent cells.
2Both are mouse-only for their main claims. Guides sequence MOTS-c after a FOXO4-DRI course.

Facts from each record, in the same words as their own pages.

FOXO4-DRI and MOTS-c side by side
	FOXO4-DRI	MOTS-c
Category	Longevity	Longevity, Weight loss
Evidence	Animal data only	Animal data only
FDA status	Not FDA approvedRegulatory	Not FDA approvedRegulatory
WADA	Not confirmed	Prohibited
Half-life	Not published for people or animals. D-amino acids resist protein-cutting enzymes, which guides say may extend its activity.Competitor guide	Never measured in people. FDA found no in-vivo study, only a lab study showing fast breakdown in human blood. Figures of 1 to 6 hours on other sites are unsourced estimates.Clinical study
Routes	Subcutaneous injection	Subcutaneous injection
Forms	Vial (powder)	Vial (powder)
Reported doses	1 to 25 mg (subcutaneous injection) 250 to 500 mcg (subcutaneous injection)	0.8 to 10 mg (subcutaneous injection) 200 to 1,000 mcg (subcutaneous injection)
Most cited frequency	Every other day for 3 doses	2 to 3 times a week
Vial sizes	10 mgCompetitor guide	5 mg, 10 mg, 20 mg, 40 mgCompetitor guide
Mixed vial keeps	Fridge, 2 to 8 C, never frozen, kept dark.Competitor guide	Fridge, 2 to 8 C, never frozen.Competitor guide
Protocols on file	7	16

Doses shown are what sources report, labelled by origin. Not medical advice.

8 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

FOXO4-DRI: the senolytic peptide that restored old mice in one studypeptidebreakdown.com · checked Oct 24, 2026
FOXO4-DRI dosage guide: senolytic protocolspeptidewiki.co · checked Oct 24, 2026
FOXO4-DRIpeptiq.io · checked Oct 24, 2026
FOXO4-DRI quick start protocolpeptidedosingprotocols.com · checked Oct 24, 2026