Skip to content

Mazdutide vs Retatrutide

Updated 10 sources

Key differences

  1. 1Retatrutide adds GIP as a third target. Mazdutide hits GLP-1 and glucagon.
  2. 2Mazdutide is approved in China; retatrutide is not approved anywhere.
  3. 3r/Peptides posters call mazdutide retatrutide's cousin and ask which works better. No head-to-head trial exists.

Side by side

Facts from each record, in the same words as their own pages.
Mazdutide and Retatrutide side by side
MazdutideRetatrutide
Category
  • GLP-1, Weight loss
  • GLP-1, Weight loss
Evidence
  • Strong human trials
  • Strong human trials
FDA status
  • In clinical trialsRegulatory
  • In clinical trialsRegulatory
WADA
  • Not prohibited
  • Not confirmed
Half-life
  • 6.3 to 16.8 days after the first dose in a phase 1b trial in Chinese adults; peak levels at a median of 72 hours.Clinical study
  • About 6 days in the phase 1b trial, with exposure rising in proportion to dose. Built for once-weekly shots.Clinical study
Routes
  • Subcutaneous injection
  • Subcutaneous injection
Forms
  • Prefilled pen, Vial (powder)
Not reported
Reported doses
  • 1 to 16 mg (subcutaneous injection)
  • 0.25 to 12 mg (subcutaneous injection)
Most cited frequency
  • Once weekly: 2 mg for 4 weeks, 4 mg for 4 weeks, then 4 or 6 mg to maintain
  • Once weekly. Start at 2 mg, step up every 4 weeks to a target of 4, 9 or 12 mg, then hold.
Vial sizes
  • 5 mg, 10 mg, 15 mg, 20 mgCompetitor guide
  • 5 mg, 10 mg, 12 mg, 15 mg, 20 mg, 24 mg, 30 mg, 40 mg, 50 mg, 60 mgCompetitor guide
Mixed vial keeps
  • Keep the mixed vial in the fridge at 2 to 8 C and never freeze it.Competitor guide
  • Keep the mixed vial in the fridge and use it within about 28 days.Community-reported
Protocols on file
  • 13
  • 18

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

10 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory2

  1. Mazdutide: First ApprovalDrugs (PubMed record), via a reference work · checked Oct 24, 2026
  2. Innovent Announces Mazdutide Received Approval from China's NMPA for Glycemic Control in Adults with Type 2 DiabetesInnovent Biologics (via BioSpace), via a news report · checked Oct 24, 2026

Reference work1

  1. MazdutideWikipedia · checked Oct 24, 2026

Community-reported2

  1. Anyone know anything about Mazdutide? Looks like Reta's cousin.r/Peptides · checked Oct 24, 2026
  2. Mazdutide vs Retatrutider/PeptideGuide · checked Oct 24, 2026