Mazdutide vs Semaglutide

Name: Mazdutide vs Semaglutide
Published: 2026-10-24

Updated Oct 24, 20266 sources

Key differences

1Semaglutide is GLP-1 only. Mazdutide adds glucagon activity aimed at energy use and liver fat.
2Innovent's DREAMS-3 phase 3 trial compares them head to head in Chinese adults with type 2 diabetes and obesity.

Facts from each record, in the same words as their own pages.

Mazdutide and Semaglutide side by side
	Mazdutide	Semaglutide
Category	GLP-1, Weight loss	GLP-1, Weight loss
Evidence	Strong human trials	Strong human trials
FDA status	In clinical trialsRegulatory	FDA approved as Ozempic +2Regulatory
WADA	Not prohibited	Not prohibited
Half-life	6.3 to 16.8 days after the first dose in a phase 1b trial in Chinese adults; peak levels at a median of 72 hours.Clinical study	About 1 week. It is still present 5 to 7 weeks after the last dose.Regulatory
Routes	Subcutaneous injection	Subcutaneous injection, Oral
Forms	Prefilled pen, Vial (powder)	Not reported
Reported doses	1 to 16 mg (subcutaneous injection)	0.125 to 7.2 mg (subcutaneous injection) 1.5 to 25 mg (oral) 300 to 1,000 mcg (subcutaneous injection)
Most cited frequency	Once weekly: 2 mg for 4 weeks, 4 mg for 4 weeks, then 4 or 6 mg to maintain	Once weekly; 4 weeks per step, then hold at 2.4 mg
Vial sizes	5 mg, 10 mg, 15 mg, 20 mgCompetitor guide	5 mg, 10 mg, 20 mg, 30 mgVendor guide
Mixed vial keeps	Keep the mixed vial in the fridge at 2 to 8 C and never freeze it.Competitor guide	Keep the mixed vial in the fridge and use it within about 28 days; one guide says 30.Competitor guide
Protocols on file	13	12

Doses shown are what sources report, labelled by origin. Not medical advice.

6 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.