MOTS-c vs SLU-PP-332

Name: MOTS-c vs SLU-PP-332
Published: 2026-10-24

Updated Oct 24, 20268 sources

Key differences

1SLU-PP-332 is a synthetic small molecule acting on ERR nuclear receptors. MOTS-c is a 16-amino-acid peptide made by mitochondria, acting through AMPK.
2WADA names MOTS-c on its 2026 List under S4.4. SLU-PP-332 is not named, and at most the catch-all S0 class could apply.

Facts from each record, in the same words as their own pages.

MOTS-c and SLU-PP-332 side by side
	MOTS-c	SLU-PP-332
Category	Longevity, Weight loss	Weight loss, Longevity
Evidence	Animal data only	Animal data only
FDA status	Not FDA approvedRegulatory	Not FDA approvedRegulatory
WADA	Prohibited	Not confirmed
Half-life	Never measured in people. FDA found no in-vivo study, only a lab study showing fast breakdown in human blood. Figures of 1 to 6 hours on other sites are unsourced estimates.Clinical study	No half-life published in any species. After a 30 mg/kg injection in mice it was still measurable in plasma and muscle 2 to 6 hours later.Clinical study One guide states about 1.5 hours in mice, without citing a study.Competitor guide
Routes	Subcutaneous injection	Subcutaneous injection, Oral
Forms	Vial (powder)	Vial (powder), Tablet, Capsule, Oral solution
Reported doses	0.8 to 10 mg (subcutaneous injection) 200 to 1,000 mcg (subcutaneous injection)	250 to 1,500 mcg (subcutaneous injection) 1 to 10 mg (subcutaneous injection) 5 to 100 mg (oral)
Most cited frequency	2 to 3 times a week	Once daily; 500 mcg a day is a common example
Vial sizes	5 mg, 10 mg, 20 mg, 40 mgCompetitor guide	5 mg, 10 mg, 20 mgVendor guide
Mixed vial keeps	Fridge, 2 to 8 C, never frozen.Competitor guide	Fridge at 2 to 8 °C, protected from light.Competitor guide
Protocols on file	16	7

Doses shown are what sources report, labelled by origin. Not medical advice.

8 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.