5-Amino-1MQ vs MOTS-c

Name: 5-Amino-1MQ vs MOTS-c
Published: 2026-10-23

Updated Oct 23, 20267 sources

Key differences

15-Amino-1MQ is an oral small molecule that blocks the enzyme NNMT. MOTS-c is an injected peptide that signals through AMPK.
2Both are mostly preclinical.

Facts from each record, in the same words as their own pages.

5-Amino-1MQ and MOTS-c side by side
	5-Amino-1MQ	MOTS-c
Category	Weight loss, Longevity	Longevity, Weight loss
Evidence	Animal data only	No human trials
FDA status	Not FDA approvedRegulatory	Not FDA approvedRegulatory
WADA	Prohibited	Prohibited
Half-life	About 3.8 hours after IV and 6.9 hours after oral dosing in rats, with 38.4% oral bioavailability. No human data.Clinical study	Never measured in people. FDA found no in-vivo study, only a lab study showing fast breakdown in human blood. Figures of 1 to 6 hours on other sites are unsourced estimates.Clinical study
Routes	Oral, Subcutaneous injection	Subcutaneous injection
Forms	Not reported	Vial (powder)
Reported doses	50 to 100 mg (oral) 2.5 to 50 mg (subcutaneous injection)	0.8 to 25 mg (subcutaneous injection) 200 to 1,000 mcg (subcutaneous injection)
Most cited frequency	Once daily	2 to 3 times a week
Vial sizes	5 mg, 10 mg, 50 mgCompetitor guide	5 mg, 10 mg, 20 mg, 40 mgCompetitor guide
Mixed vial keeps	Keep the mixed vial at 2 to 8 °C, away from light, and use it within 2 to 4 weeks.Competitor guide	Fridge, 2 to 8 C, never frozen.Competitor guide
Protocols on file	8	17

Doses shown are what sources report, labelled by origin. Not medical advice.

7 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.