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N-Acetyl Semax Amidate vs Semax

Updated 12 sources

Key differences

  1. 1Same seven amino acids plus an acetyl cap and an amide cap, so 855.0 g/mol vs 813.9 for Semax.
  2. 2Guides claim 2 to 3 times the potency per mcg and longer action; no study has measured either.
  3. 3Semax has Russian trials and a Russian drug registration. The amidate has no human or animal study.
  4. 4In a lab study, acetylating Semax removed its protection of nerve cells against copper toxicity.
  5. 5Guides disagree on dose: one says cut the Semax dose, others start at or above it.
  6. 6The acetylated form is claimed to be 2 to 3 times stronger per mcg, with starts of 100 to 200 mcg.
  7. 7In one lab study, acetylation changed how Semax binds copper and removed its cell-protection effect.
  8. 8There is no human data on the acetylated form.

Side by side

Facts from each record, in the same words as their own pages.
N-Acetyl Semax Amidate and Semax side by side
N-Acetyl Semax AmidateSemax
Category
  • Cognitive
  • Cognitive
Evidence
  • No human trials
  • Limited human data
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • Not measured. One guide estimates about 30 to 45 minutes, longer than Semax.Competitor guide
  • Not measured. Other guides claim several hours, or 2 to 10 hours vs 0.5 to 2 for Semax.Competitor guide
  • No human data; FDA found no human pharmacokinetic studies. In rats, brain levels peak 2 minutes after a nasal dose and the peptide breaks down fast.Clinical study
Routes
  • Nasal, Subcutaneous injection
  • Nasal, Subcutaneous injection
Forms
  • Nasal spray, Vial (powder)
  • Nasal spray, Vial (powder)
Reported doses
  • 200 to 1,200 mcg (nasal)
  • 200 to 1,000 mcg (subcutaneous injection)
  • 150 to 6,000 mcg (nasal)
  • 12 to 18 mg (nasal)
  • 15 to 50 mcg/kg (nasal)
Most cited frequency
  • 1 to 2 times a day
  • Once daily
Vial sizes
  • 30 mgCommunity-reported
  • 5 mg, 10 mg, 20 mg, 30 mgCompetitor guide
Mixed vial keeps
  • Fridge at 2 to 8 C, use within 14 to 21 days.Competitor guide
  • Fridge at 2 to 8 C.Competitor guide
Protocols on file
  • 9
  • 30

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

12 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Reference work1

  1. N-acetyl semax amidate (CID 172638603)PubChem · checked Oct 24, 2026

Competitor guide5

  1. Semax (FAQ: N-Acetyl Semax version)peptidesexplorer.com · checked Oct 24, 2026
  2. NA Semax Amidate vs Semaxpeptide-db.com · checked Oct 24, 2026
  3. N-Acetyl Semax Amidatepeptides.org · checked Oct 24, 2026
  4. NA-Semax Amidatebodyhackguide.co · checked Oct 24, 2026