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Adamax vs Semax

Updated 10 sources

Key differences

  1. 1Semax is a seven amino acid ACTH fragment. Adamax is sold as Semax plus an N-terminal acetyl cap and a C-terminal adamantane group, per its developer.
  2. 2Semax is a registered medicine in Russia with small, mostly Russian human studies. Adamax is approved nowhere and has no published study of any kind.
  3. 3Russian Semax literature, as cited by a competitor guide, used about 0.6 to 1.5 mg a day intranasally. No studied Adamax dose exists.
  4. 4Users describe Semax as short-acting and Adamax as lasting all day. No pharmacokinetic data backs either claim for Adamax.
  5. 5Users split on strength: some find Semax clearer and stronger, others say Adamax hits harder and lasts longer.
  6. 6Some users place N-acetyl Semax amidate between the two, and the 984 Da Adamax product matches that description.
  7. 7Adamax has no published studies and no measured half-life, so claims that it lasts longer are untested.
  8. 8Some users call Adamax stronger.

Side by side

Facts from each record, in the same words as their own pages.
Adamax and Semax side by side
AdamaxSemax
Category
  • Cognitive
  • Cognitive
Evidence
  • No human trials
  • Limited human data
FDA status
  • FDA status unclear
  • Not FDA approvedRegulatory
WADA
  • Not confirmed
  • Not confirmed
Half-life
  • Not measured for Adamax. No human or animal pharmacokinetic study exists. Claims that it lasts several times longer than Semax are vendor copy.Community-reported
  • No human data; FDA found no human pharmacokinetic studies. In rats, brain levels peak 2 minutes after a nasal dose and the peptide breaks down fast.Clinical study
Routes
  • Nasal, Subcutaneous injection
  • Nasal, Subcutaneous injection
FormsNot reported
  • Nasal spray, Vial (powder)
Reported doses
  • 100 to 300 mcg (nasal)
  • 250 to 1,000 mcg (subcutaneous injection)
  • 0.2 to 0.4 mg (subcutaneous injection)
  • 150 to 6,000 mcg (nasal)
  • 12 to 18 mg (nasal)
  • 15 to 50 mcg/kg (nasal)
Most cited frequency
  • Once daily
  • Daily total
Vial sizes
  • 10 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mgCompetitor guide
Mixed vial keeps
  • Keep mixed vials in the fridge at 2 to 8 °C.Competitor guide
  • Fridge at 2 to 8 C.Competitor guide
Protocols on file
  • 10
  • 30

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

10 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.

Vendor guide2

  1. Adamax (984 Da)araratpeptides.com · checked Oct 23, 2026
  2. Adamax and P21: two new nootropic peptides to watchjaycampbell.com · checked Oct 23, 2026

Competitor guide2

  1. Semax Peptide Dosing Guidepeptidedosingprotocols.com · checked Oct 23, 2026
  2. Adamax protocolpeptidedosingprotocols.com · checked Oct 23, 2026

Community-reported2

  1. r/Peptides comment on Semaxr/Peptides · checked Oct 23, 2026
  2. Has anyone tried Adamax spray (vendor copy quoted)r/Nootropics · checked Oct 23, 2026