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Dihexa vs Semax

Updated 6 sources

Key differences

  1. 1Semax is an ACTH fragment used by nose at microgram doses; Dihexa is used at milligram doses by mouth or skin.
  2. 2They are often stacked rather than swapped.

Side by side

Facts from each record, in the same words as their own pages.
Dihexa and Semax side by side
DihexaSemax
Category
  • Cognitive
  • Cognitive
Evidence
  • Animal data only
  • Limited human data
FDA status
  • Not FDA approvedRegulatory
  • Not FDA approvedRegulatory
WADA
  • Prohibited
  • Not confirmed
Half-life
  • 12.68 days after IV dosing and about 8.8 days after IP dosing in rats, from a paper now under an expression of concernClinical study
  • About 1.5 hours in people for ATH-1001, the active metabolite of the related prodrug fosgonimeton; whether ATH-1001 is Dihexa is disputedClinical study
  • No human data; FDA found no human pharmacokinetic studies. In rats, brain levels peak 2 minutes after a nasal dose and the peptide breaks down fast.Clinical study
Routes
  • Oral, Topical, Sublingual
  • Nasal, Subcutaneous injection
Forms
  • Capsule, Oral solution, Topical, Vial (powder), Nasal spray, Other form
  • Nasal spray, Vial (powder)
Reported doses
  • 5 to 100 mg (oral)
  • 4 to 40 mg (topical)
  • 1 to 5% (topical)
  • 150 to 6,000 mcg (nasal)
  • 12 to 18 mg (nasal)
  • 15 to 50 mcg/kg (nasal)
Most cited frequency
  • Once daily
  • Once daily
Vial sizes
  • 10 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mgCompetitor guide
Mixed vial keeps
  • Mixed solution: refrigerate at 2 to 8 C and use within 14 days.Competitor guide
  • Fridge at 2 to 8 C.Competitor guide
Protocols on file
  • 8
  • 30

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

6 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.