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5-Amino-1MQ vs Semaglutide

Updated 7 sources

Key differences

  1. 1Semaglutide 2.4 mg weekly produced 14.9% mean weight loss against 2.4% on placebo at 68 weeks in STEP 1 (1,961 adults). 5-Amino-1MQ has no human trial.
  2. 2In obese mice, 5-Amino-1MQ gave about 5.1% weight loss over 11 days against a 1.4% gain in controls, with no change in food intake.
  3. 3Semaglutide works by cutting appetite. 5-Amino-1MQ targets cellular energy metabolism, which is why people stack them instead of choosing.
  4. 4Semaglutide is an FDA-approved weekly injection. 5-Amino-1MQ is unapproved and mostly taken as daily oral capsules.

Side by side

Facts from each record, in the same words as their own pages.
5-Amino-1MQ and Semaglutide side by side
5-Amino-1MQSemaglutide
Category
  • Weight loss, Longevity
  • GLP-1, Weight loss
Evidence
  • Animal data only
  • Strong human trials
FDA status
  • Not FDA approvedRegulatory
  • FDA approved as Ozempic +2Regulatory
WADA
  • Prohibited
  • Not prohibited
Half-life
  • About 3.8 hours after IV and 6.9 hours after oral dosing in rats, with 38.4% oral bioavailability. No human data.Clinical study
  • About 1 week. It is still present 5 to 7 weeks after the last dose.Regulatory
Routes
  • Oral, Subcutaneous injection
  • Subcutaneous injection, Oral
Reported doses
  • 50 to 100 mg (oral)
  • 2.5 to 50 mg (subcutaneous injection)
  • 0.125 to 7.2 mg (subcutaneous injection)
  • 1.5 to 25 mg (oral)
  • 300 to 1,000 mcg (subcutaneous injection)
Most cited frequency
  • Once daily
  • Once weekly; 4 weeks per step, then hold at 2.4 mg
Vial sizes
  • 5 mg, 10 mg, 50 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mgVendor guide
Mixed vial keeps
  • Keep the mixed vial at 2 to 8 °C, away from light, and use it within 2 to 4 weeks.Competitor guide
  • Keep the mixed vial in the fridge and use it within about 28 days; one guide says 30.Competitor guide
Protocols on file
  • 8
  • 12

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

7 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.