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AOD-9604 vs Semaglutide

Updated 5 sources

Key differences

  1. 1Semaglutide 2.4 mg weekly cut body weight by 14.9% vs 2.4% on placebo over 68 weeks in STEP 1.
  2. 2AOD-9604's largest trial (502 randomized, oral 0.25 to 1 mg for 24 weeks) found no significant weight-loss difference from placebo, and obesity development ended in 2007.
  3. 3Semaglutide suppresses appetite; AOD-9604 showed no appetite, glucose or insulin effect in animals.
  4. 4Semaglutide is an approved drug. AOD-9604 is unapproved and has no lawful compounding route.

Side by side

Facts from each record, in the same words as their own pages.
AOD-9604 and Semaglutide side by side
AOD-9604Semaglutide
Category
  • Weight loss
  • GLP-1, Weight loss
Evidence
  • Limited human data
  • Strong human trials
FDA status
  • Not FDA approvedRegulatory
  • FDA approved as Ozempic +2Regulatory
WADA
  • Prohibited
  • Not prohibited
Half-life
  • About 3 minutes after an IV bolus in pigs and about 4 minutes in rat blood in vitro. No human subcutaneous data.Clinical study
  • About 1 week. It is still present 5 to 7 weeks after the last dose.Regulatory
Routes
  • Oral, Subcutaneous injection
  • Subcutaneous injection, Oral
Reported doses
  • 0.25 to 30 mg (oral)
  • 250 to 500 mcg (subcutaneous injection)
  • 1 to 2 mg (subcutaneous injection)
  • 0.125 to 7.2 mg (subcutaneous injection)
  • 1.5 to 25 mg (oral)
  • 300 to 1,000 mcg (subcutaneous injection)
Most cited frequency
  • Once daily
  • Once weekly; 4 weeks per step, then hold at 2.4 mg
Vial sizes
  • 2 mg, 5 mg, 10 mgCompetitor guide
  • 5 mg, 10 mg, 20 mg, 30 mgVendor guide
Mixed vial keeps
  • Keep at 2 to 8 °C, away from light, and do not freeze and thaw.Community-reported
  • Keep the mixed vial in the fridge and use it within about 28 days; one guide says 30.Competitor guide
Protocols on file
  • 12
  • 12

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

5 sources, each checked by date. Record updated Oct 23, 2026. Numbers are restated in our own words and labelled by where they came from.