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Ipamorelin vs Sermorelin

Updated 11 sources

Key differences

  1. 1Sermorelin is GHRH(1-29) and was once an FDA-approved drug (Geref) with pediatric data. Ipamorelin is a GHRP that was never approved.
  2. 2Ipamorelin's half-life is about 2 hours after IV dosing; sermorelin's is measured in minutes.
  3. 3Sermorelin acts on the GHRH receptor; ipamorelin on the ghrelin receptor. They are usually stacked.
  4. 4Sermorelin was FDA approved and has pediatric data. Ipamorelin was never approved, and its half-life is about 2 hours after IV dosing.

Side by side

Facts from each record, in the same words as their own pages.
Ipamorelin and Sermorelin side by side
IpamorelinSermorelin
Category
  • GH axis
  • GH axis
Evidence
  • Limited human data
  • Some human trials
FDA status
  • Not FDA approvedRegulatory
  • Formerly approved as GerefRegulatory
WADA
  • Prohibited
  • Prohibited
Half-life
  • About 2 hours after IV infusion in healthy men. Subcutaneous half-life has not been published.Clinical study
  • Minutes. 10.4 minutes after IV dosing in rats, about 4.3 minutes in a review table, and 10 to 20 minutes per guides.Competitor guide
Routes
  • Subcutaneous injection
  • Subcutaneous injection
Reported doses
  • 100 to 400 mcg (subcutaneous injection)
  • 100 to 500 mcg (subcutaneous injection)
Most cited frequency
  • Once daily, before bed
  • Once daily at bedtime
Vial sizes
  • 2 mg, 5 mg, 10 mgCompetitor guide
  • 5 mg, 6 mg, 10 mgCompetitor guide
Mixed vial keeps
  • Fridge, 2 to 8 °C.Competitor guide
  • Fridge, 2 to 8 °C.Competitor guide
Protocols on file
  • 10
  • 11

Doses shown are what sources report, labelled by origin. Not medical advice.

Read each in full

Sources

11 sources, each checked by date. Record updated Oct 24, 2026. Numbers are restated in our own words and labelled by where they came from.

Regulatory4

  1. Certain bulk drug substances, safety risksFDA · checked Oct 23, 2026
  2. 503A bulk drug substance categories (May 14, 2026)FDA · checked Oct 23, 2026
  3. Drugs@FDA Geref records (openFDA)FDA · checked Oct 23, 2026
  4. Determination that Geref was not withdrawn for safety or effectivenessFederal Register · checked Oct 24, 2026

Competitor guide3

  1. SermorelinPeptidesExplorer · checked Oct 23, 2026
  2. Sermorelin dosage guideBodyHackGuide · checked Oct 23, 2026
  3. Sermorelin dosage guidePeptideDeck · checked Oct 23, 2026